Heterogeneity in age-related functional changes in later life and its association with social serucity needs

• Project/Area Number: 26310111
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 特設分野
• Research Field: Neo-Gerontology
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: SHINKAI Shoji 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 副所長 (60171063)
• Co-Investigator(Kenkyū-buntansha): 谷口 優 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (40636578) ; 清野 諭 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (50725827) ; 西 真理子 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (70543601) ; 天野 秀紀 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究助手 (90260306) ; 村山 洋史 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (00565137) ; 北村 明彦 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (80450922)
• Project Period (FY): 2014-07-18 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000); Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
• Keywords: 生活機能 / 高齢者 / 加齢変化 / 個人差 / 社会保障ニーズ / 類型化 / 心身機能

Outline of Final Research Achievements

This study was the first to show the heterogeneity of age-related functional change in later life. 36.3% and 40.1% of older adults remained independent until 85 and 80 years of age on the average in terms of higher order functional capacity as assessed by TMIG-IC. On the other hand, 17.4% of older adults became frail(as defined by TMIG-IC less than 10 scores) around the age of 75 years and 6.1% of those were already frail at the age of 65 years. The former two groups consumed more health care cost with advancing ages, but consumed very low cost of long-term care until 90 years of age. The total cost of health care and long-term care in the two groups did not increase so much and remained relatively low even at very advanced ages. In the super-aged society, Japan, we can expect more potential of productivity for 75% of older population. On the other hand, one fourth of older population had high social security need even in young old ages and need the special attention.

Research Products

• [Journal Article] Changes in health behaviors and the trajectory of body mass index among older Japanese: a 19-year longitudinal study (2017)
  • Author(s): Murayama H, Liang J, Shaw BA, Botoseneanu A, Kobayashi E, Fukaya T, Shinkai S
  • Journal Title: Geriatr Gerontol Int Volume: 印刷中 Issue: 11 Pages: 2008-2016
  • DOI: 10.1111/ggi.13008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mini-Mental State Examination Score Trajectories and Incident Disabling Dementia Among Community-Dwelling Older Japanese (2017)
  • Author(s): Taniguchi Y, Kitamura A, Murayama H, Amano H, Shinozaki T, Yokota I, Seino S, Nofuji Y, Nishi M, Yokoyama Y, Matsuyama Y, Fujiwara Y, Shinkai S
  • Journal Title: Geriatr Gerontol Int Volume: 印刷中 Issue: 11 Pages: 1928-1935
  • DOI: 10.1111/ggi.12996
  • Peer Reviewed / Open Access
• [Journal Article] Gait performance trajectories and incidence of dementia (2017)
  • Author(s): Taniguchi Y, Kitamura A, Seino S, Murayama H, Amano H, Nofuji Y, Nishi M, Yokoyama Y, Shinozaki T, Yokota I, Matsuyama Y, Fujiwara Y, Shinkai S
  • Journal Title: J Am Med Dir Assoc Volume: 印刷中 Issue: 2 Pages: 192.e13-192.e20
  • DOI: 10.1016/j.jamda.2016.10.015
  • Peer Reviewed / Open Access
• [Journal Article] Albumin, hemoglobin, and the trajectory of cognitive function in community-dwelling older Japanese: a 13-year longitudinal study (2017)
  • Author(s): Murayama H, Shinkai S, Nishi M, Taniguchi Y, Amano H, Seino S, Yokoyama Y, Yoshida H, Fujiwara Y, Ito H
  • Journal Title: J Prev Alzheimer's Dis Volume: 印刷中
• [Journal Article] Dietary variety and decline in lean mass and physical performance in community-dwelling older Japanese: A 4-year follow-up study. (2016)
  • Author(s): Yokoyama Y, Nishi M, Murayama H, Amano H, Taniguchi Y, Nofuji Y, Narita M, Matsuo E, Seino S, Kawano Y, Shinkai S.
  • Journal Title: Journal of Nutrition, Health and Aging Volume: 印刷中 Issue: 1 Pages: 11-16
  • DOI: 10.1007/s12603-016-0726-x
  • Peer Reviewed / Open Access
• [Journal Article] Prospective study of trajectories of physical performance and mortality among community-dwelling older Japanese (2016)
  • Author(s): Taniguchi Y, Fujiwara Y, Murayama H, Yokota I, Matsuo E, Seino S, Nofuji Y, Nishi M, Matsuyama Y, Shinkai S
  • Journal Title: J Gerontol A Biol Sci Med Sci Volume: 71 Pages: 1492-1499
  • Peer Reviewed / Open Access
• [Journal Article] Association of dietary variety with body composition and physical function in community-dwelling elderly Japanese. (2016)
  • Author(s): Yokoyama Y, Nishi M, Murayama H, Amano A, Taniguchi Y, Nofuji Y, Narita M, Matsuo E, Seino S, Kawano Y, Shinkai S.
  • Journal Title: Journal of Nutrition, Health and Aging Volume: 印刷中 Issue: 7 Pages: 691-696
  • DOI: 10.1007/s12603-015-0632-7
  • Peer Reviewed / Open Access
• [Journal Article] Associations of Walking Speed, Grip Strength, and Standing Balance with Total and Cause-Specific Mortality in a General Population of older Japanese (2016)
  • Author(s): Nofuji Y, Shinkai S, Taniguchi Y, Amano H, Nishi M, Murayama H, Fujiwara Y, Suzuki T
  • Journal Title: J Am Med Dir Assoc Volume: 7 Issue: 2 Pages: 184-184
  • DOI: 10.1016/j.jamda.2015.11.003
  • Peer Reviewed / Open Access
• [Journal Article] Public health approach to preventing frailty in the community and its effect on healthy aging in Japan (2016)
  • Author(s): Shinkai S, Yoshida H, Taniguchi Y, Murayama H, Nishi M, Amano H, Nofuji Y, Seino S, Fujiwara Y
  • Journal Title: Geriatr Gerontol Int Volume: 16 Issue: S1 Pages: 87-97
  • DOI: 10.1111/ggi.12726
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Associations of walking speed, grip strength, and standing balance with total and cause-specific mortality in a general population of Japanese elders (2016)
  • Author(s): Nofuji Y, Shinkai S, Taniguchi Y, Amano H, Nishi M, Murayama H, Fujiwara Y, Suzuki T
  • Journal Title: Journal of American Directors Association Volume: 17
  • Peer Reviewed / Open Access
• [Journal Article] Public health approach to preventing frailty in the community and its effects on healthy aging in Japan (2016)
  • Author(s): Shinkai S, Yoshida H, Taniguchi Y, Murayama H, Nishi M, Amano H, Nofuji Y, Seino S, Fujiwara Y
  • Journal Title: Geriatrics Gerontology International Volume: 16 (Suppl.1) Pages: 87-97
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 高齢者向けの集団健診が余命および健康余命に及ぼす影響－草津町介護予防事業１０年間の効果評価の試み－ (2016)
  • Author(s): 西真理子, 吉田裕人, 藤原佳典, 深谷太郎, 天野秀紀, 熊谷修, 渡辺修一郎, 村山洋史, 谷口優, 干川なつみ, 土屋由美子, 新開省二
  • Journal Title: 厚生の指標 Volume: 63 (2) Pages: 2-11
  • Peer Reviewed
• [Journal Article] Reference values and age differences in body composition of community-dwelling older Japanese men and women: A pooled analysis of four cohort studies (2015)
  • Author(s): Seino S, Shinkai S, Iijima K, Obuchi S, Fujiwara Y, Yoshida H, Kawai H, Nishi M, Murayama H, Taniguchi Y, Amano H, Takahashi R
  • Journal Title: PLos ONE Volume: 10 Issue: 7 Pages: e0131975-e0131975
  • DOI: 10.1371/journal.pone.0131975
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Trajectories of body mass index and their associations with morality among older Japanese: Do they differ from Western populations? (2015)
  • Author(s): Murayama H, Liang J, Bennett JM, Shaw BA, Botoseneanu A, Kobayashi E, Fukaya T, Shinkai S
  • Journal Title: American Journal of Epidemiology Volume: 182 Issue: 7 Pages: 597-605
  • DOI: 10.1093/aje/kwv107
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Longitudinal association between neighborhood cohesion and depressive mood in old age: A Japanese prospective study (2015)
  • Author(s): Murayama H, Nishi M, Nofuji Y, Matsuo E, Taniguchi Y, Amano H, Yokoyama Y, Fujiwara Y, Shinkai S
  • Journal Title: Health & Place Volume: 34 Pages: 270-278
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cardiometabolic risk, socio-psychological factors, and trajectory of grip strength among older adults (2015)
  • Author(s): Botoseneanu A, Bennett JM, Nyquist L. Shinkai S, Fujiwara Y, Yoshida H, Aiello A, Cigolle CT, Liang J
  • Journal Title: Journal of Aging and Health Volume: 27 Issue: 7 Pages: 1123-1146
  • DOI: 10.1177/0898264315577587
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prospective Study of Arterial Stiffness and Subsequent Cognitive Decline Among Community-Dwelling Older Japanese (2015)
  • Author(s): Yu Taniguchi、Yoshinori Fujiwara、Mariko Nishi、Hiroshi Murayama、Yu Nofuji、Satoshi Seino、Rika Tajima、Yutaka Matsuyama、Shoji Shinkai.
  • Journal Title: Journal of Epidemiology Volume: 25 Issue: 9 Pages: 592-599
  • DOI: 10.2188/jea.JE20140250
  • NAID: 130005096831
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 地域在住高齢者に対する虚弱予防教室による虚弱および食習慣の改善効果 (2015)
  • Author(s): 川畑輝子, 武見ゆかり, 村山洋史, 西真理子, 清水由美子, 成田美紀, 金美芝, 新開省二
  • Journal Title: 日本公衆衛生学雑誌 Volume: 62 Pages: 169-181
  • NAID: 130005076411
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Are neighborhood bonding and bridging social capital protective against depressive mood in old age? A multilevel analysis in Japan (2015)
  • Author(s): Murayama H, Nofuji Y, Matsuo E, Nishi M, Taniguchi Y, Fujiwara Y, Shinkai S
  • Journal Title: Social Science and Medicine Volume: 124 Pages: 171-179
  • DOI: 10.1016/j.socscimed.2014.11.042
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Does social support buffer the effect of financial strain on the trajectory of smoking in older Japanese? A 19-year longitudinal study (2015)
  • Author(s): Murayama, H., Bennett, J. M., Shaw, B. A., Liang, J., Krause, N., Kobayashi, E., Fukaya, T., & Shinkai, S.
  • Journal Title: Journal of Gerontology Series B: Psychological Sciences and Social Sciences Volume: 70（３） Issue: 3 Pages: 367-376
  • DOI: 10.1093/geronb/gbt103
  • Peer Reviewed
• [Journal Article] Reference Values and Age and Sex Differences in Physical Performance Measures for Community-Dwelling Older Japanese: A Pooled Analysis of Six Cohort Studies (2014)
  • Author(s): Seino S, Shinkai S, Fujiwara Y, Obuchi S, Yoshida H, Hirano H, Kim HK, Ishizaki T, Takahashi R; TMIG-LISA Research Group
  • Journal Title: PLOS ONE Volume: 9 Issue: 6 Pages: e99487-e99487
  • DOI: 10.1371/journal.pone.0099487
  • Peer Reviewed / Open Access
• [Journal Article] Nutritional biomarkers and subsequent cognitive decline among community-dwelling older Japanese: A prospective study. (2014)
  • Author(s): Taniguchi Y, Shinkai S, et al （他5名）
  • Journal Title: Journal of Gerontology: Biological Sciences & Medical Sciences Volume: 印刷中 Issue: 10 Pages: 1276-1283
  • DOI: 10.1093/gerona/glt286
  • Peer Reviewed / Open Access
• [Journal Article] Regional cerebral glucose metabolism and gait speed in healthy community-dwelling older women. (2014)
  • Author(s): Sakurai R, Fujiwara Y, Yasunaga M, Takeuchi R, Murayama Y, Ohba H, Sakuma N, Suzuki H, Oda K, Sakata M, Toyohara J, Ishiwata K, Shinkai S, Ishii K
  • Journal Title: J Gerontol A Biol Sci Med Sci Volume: 69 Issue: 12 Pages: 1519-27
  • DOI: 10.1093/gerona/glu093
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Short and long-term effects of a multifactorial intervention for pre-frail and frail elderly on their functional health: a randomized, controlled, crossover trial within a cohort study (2017)
  • Author(s): Shinkai S, Seino S
  • Organizer: The 12th International Symposium on Geriatrics and Gerontology entitled "Frailty and dementia- From its pathogenesis to prevention and treatment-"
  • Place of Presentation: Obu, Aichi, Japan
  • Year and Date: 2017-03-04
  • Int'l Joint Research / Invited
• [Presentation] Knowledge transition about frailty prevention- From prevention to practice (2016)
  • Author(s): Shinkai S
  • Organizer: Second Mexico-Japan Meeting on Healthy Ageing
  • Place of Presentation: Mexico City, Mexico
  • Year and Date: 2016-06-20
  • Int'l Joint Research / Invited
• [Presentation] Community based strategy for preventing frailty (2016)
  • Author(s): Shinkai S, Seino S
  • Organizer: International Seminar on Frailty Cohort & Intervention Study
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-05-16
  • Int'l Joint Research / Invited
• [Presentation] How to build an age-friendly city through social participation (2016)
  • Author(s): Shinkai S
  • Organizer: Conference for Age-Friendly City Strategies of Busan
  • Place of Presentation: Busan, Korea
  • Year and Date: 2016-05-12
  • Int'l Joint Research / Invited
• [Presentation] A public health approach for frailty prevention in community and its impact upon healthy aging in Japan (2015)
  • Author(s): Shinkai S, Nishi M, Taniguchi Y, Murayama H, Amano H, Nofuji Y, Seino S, Fujiwara H, Ikeuchi T
  • Organizer: The 68th Annual Scientific Meeting of Gerontological Society of America (GSA)
  • Place of Presentation: Orland, USA
  • Year and Date: 2015-11-18
  • Int'l Joint Research
• [Presentation] Gerontology in Japan and state-of-art projects in Japan. (2015)
  • Author(s): Shinkai S, Ikeuchi T
  • Organizer: Japan-UK Reseach and Education Network for Knowledge Economy Initiatives Workshop at Osaka University
  • Place of Presentation: Osaka University (Suita, Japan)
  • Year and Date: 2015-10-23
  • Int'l Joint Research / Invited
• [Presentation] Public health approach for frailty prevention in a community and its impact upon healthy aging: A 10-year community intervention in Japan (2015)
  • Author(s): Shinkai S
  • Organizer: The 21th Congress of the International Association of Gerontology and Geriatrics (IAGG)
  • Place of Presentation: Chiang Mai, Thailand
  • Year and Date: 2015-10-19
  • Int'l Joint Research
• [Presentation] 草津町における介護予防共同研究事業からみた高齢者保健の課題 (2015)
  • Author(s): 新開省二, 吉田裕人, 藤原佳典, 天野秀樹, 西真理子, 村山洋史, 谷口優, 野藤悠, 清野諭, 岡部たづる, 干川なつみ
  • Organizer: 第７４回日本公衆衛生学会総会
  • Place of Presentation: 長崎ブリックホールほか（長崎県・長崎市）
  • Year and Date: 2015-10-04
• [Presentation] 地域における介護予防１０年間の取り組み、その成果と課題 (2015)
  • Author(s): 新開省二
  • Organizer: 第７０回日本体力医学会大会
  • Place of Presentation: 和歌山県民文化会館ほか（和歌山県・和歌山市）
  • Year and Date: 2015-09-18
• [Presentation] Good nutrition and physical function as a key component for healthy aging: Results from cohort studies on Japanese older adults (2015)
  • Author(s): Shinkai S
  • Organizer: The 12th Asian Congress of Nutrition
  • Place of Presentation: Pacifico Yokohama (Yokohama, Japan)
  • Year and Date: 2015-05-14
  • Int'l Joint Research / Invited
• [Presentation] Prevention of frailty and healthy aging: a 10-year community intervention in Japan (2015)
  • Author(s): Shinkai S
  • Organizer: Mexico-Japan Encounter on Active and Healthy Aging
  • Place of Presentation: Mexico City, Mexico
  • Year and Date: 2015-02-10
  • Invited
• [Presentation] A prospective study on nutritional state and active life expectancy in a general population of older Japanese (2015)
  • Author(s): 40.Shinkai S, Nishi M, Taniguchi Y, Amano H, Murayama H, Nofuji Y, Seino S, Narita M, Matsuo E, Yokoyama Y, Fujiwara Y
  • Organizer: 第25回日本疫学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-01-21 – 2015-01-23
• [Presentation] Physical, nutritional and social aspects of healthy aging in Japan: Longitudinal Interdisciplinary Study on Aging (TMIG-LISA) (2014)
  • Author(s): Shinkai S
  • Organizer: "Healthy Aging" symposium in 2014 Global Health Forum in Taiwan
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2014-11-30 – 2014-12-01
  • Invited
• [Presentation] Association between dietary variety and body composition and physical function in community-dwelling elderly Japanese people (2014)
  • Author(s): 4.Yokoyama Y, Nishi M, Murayama H, Amano H, Taniguchi Y, Narita M, Kawano Y, Shinkai S
  • Organizer: The Gerontological Society of America 67th Annual Scientific Meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-05 – 2014-11-09
• [Presentation] Trajectories of Body Mass Index and All-cause Mortality: Findings from the National Survey of the Japanese Elderly (2014)
  • Author(s): 5.Murayama H, Liang J, Bennett JM, Shaw BA, Botoseneanu A, Kobayashi E, Akiyama H, Shinkai S
  • Organizer: The Gerontological Society of America 67th Annual Scientific Meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-05 – 2014-11-09
• [Presentation] Risk factors of Cognitive Decline in Japanese Commurity Dwellers : a 10-Year Cohort Study (2014)
  • Author(s): 7.Amano H, Yoshida H, Fujiwara Y, Nishi M, Murayama H, Taniguchi Y, Nofuji Y, Shinkai S
  • Organizer: The Gerontological Society of America 67th Annual Scientific Meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-05 – 2014-11-09
• [Presentation] Promoting healthy aging. A 10-year community intervention for frailty prevention and its impact upon healthy aging in Japan (2014)
  • Author(s): Shinkai S
  • Organizer: New Frontiers in Research on Aing and Health, 2014 Joint Symposium of the Graduate School & Institute on Aging, Ajou University School of Medicine
  • Place of Presentation: Suwon, Korea
  • Year and Date: 2014-09-20
  • Invited