| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Outline of Final Research Achievements |
Organelle transport by kinesin and dynein is deeply related to medical and cosmetic issues. For example, deficit of the transport is a problem as to Alzheimer disease, and melanin pigment produced by sunburn is also transported by kinesin and dynein as melanosomes. The theorems of non-equilibrium statistical mechanics were applied to the in vivo transport because the transport was represented by non-equilibrium stochastic processes. Concretely, we investigated synaptic vesicle precursor transport and melanosome transport. The physical reasons of mis-location of synapses and the effect of dynein inhibitor called ciliobrevin on force and number of motors were clarified.
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