| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
We studied the role of orbitofrontal cortex (OFC) in this type of decision making during a choice task varying reward amount and work or time to reward. We recorded neurons and found them coding for aspects of choice-related values. Neuronal activity in OFC represented reward value in various combinations of difference in or sum of value of offered alternatives. We then reversibly inactivated a small regions of OFC rich in neurons coding for choice-related values. During the period of pharmacological OFC inactivation by muscimol the monkeys were both slower to choose and more likely to choose the less valuable option, especially when the difference in value between the two options was small. Thus, OFC neurons code for information that could be used to guide choices, and inactivating this tissue suggests that these signals have a direct influence on the choice behavior.
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