Establishment of developing method of a diagnostic system for psychiatric diseases with a novel big data analysis method
| Project/Area Number |
26330325
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Life / Health / Medical informatics
|
|---|
| Research Institution | Tokyo University of Agriculture and Technology |
|---|
Principal Investigator |
Ishii Kazuo 東京農工大学, (連合)農学研究科(研究院), 特任教授 (60449238)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
Ohmori Tetsuro 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (00221135)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 数理モデル化 / 変数選択 / モデル最適化 / 次世代シーケンサー / マイクロアレイ / 高次元データ / 精神神経系疾患 / 臨床診断薬 / 次元削減 / 判別分析 / 汎化 / うつ病 / 総合失調症 / 双極性障害 / 計算機統計学 / モンテカルロ法 / 並列分散処理 / 正則化 / 表現型予測 / クラウドコンピューティング / 精神神経系診断薬 / ビッグデータ / エピゲノミクス |
|---|
| Outline of Final Research Achievements |
Clinical application of large-scale data analysis systems for multidimensional data, including next generation sequencer and micro-array, is progressing. Mathematical models with multidimensional data and its application to clinical diagnosis is promising. In this research, we aimed to establish a method to select multiple variables from these data and to create a mathematical model combining these markers. In this study, we analyzed psychiatric diseases using DNA and RNA samples from blood specimens from the patients, and performed variable selection, mathematical modeling and optimization. And finally we established a high precision mathematical modeling method.
|
Report
(4 results)
Research Products
(41 results)
-
-
-
-
-
[Journal Article] Blood Diagnostic Biomarkers for Major Depressive Disorder using Multiplex DNA Methylation Profiles: Discovery and Validation.2015
Author(s)
Shusuke Numata, Kazuo Ishii, Atsushi Tajima, Jun-Ichi Iga, Makoto Kinoshita, Shinya Watanabe, Hidehiro Umehara, Manabu Fuchikami, Satoshi Okada, Shuken Boku, Akitoyo Hishimoto, Shinji Shimodera, Issei Imoto, Shigeru Morinobu, Tetsuro Ohmori
-
Journal Title
Epigenetics
Volume: 10(2)
Issue: 2
Pages: 135-141
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Blood diagnostic biomarkers for major depressive disorder using DNA methylation profiles.2014
Author(s)
Shusuke Numata, Ishii Kazuo, Atsushi Tajima, Junichi Iga, Makoto Kinoshita, Shinya Watanabe, Hidehiro Umehara, Fuchikami Manabu, Okada Satoshi, Shimodera Shinji, Issei Imoto, Morinobu Shigeru and Tetsuro Ohmori
Organizer
Neuroscience 2015
Place of Presentation
Washington DC, USA
Year and Date
2014-11-15 – 2014-11-19
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] ビッグデータの収集、調査、分析と活用事例2015
Author(s)
村田正徳, 石垣司, 工藤卓哉, 石川智也, 清水誠, 中崎尚, 佐々木宏, 達野大輔, 森正弥, 河野洋一, 横山彰吾, 大木真吾, 内田圭亮, 広瀬穣治, 堀雅和, 秋山昌範, 後藤光治, 若杉徹, 横垣裕史, 石井一夫，他33名
Total Pages
345
Publisher
技術情報協会
Related Report
-
-
-
-
-
