| Project/Area Number |
26330326
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Life / Health / Medical informatics
|
|---|
| Research Institution | Yokohama National University |
|---|
Principal Investigator |
Amemiya Takashi 横浜国立大学, 大学院環境情報研究院, 教授 (60344149)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
伊藤 公紀 横浜国立大学, 大学院環境情報研究院, 教授 (40114376)
山口 智彦 国立研究開発法人産業技術総合研究所, その他部局等, 研究員 (70358232)
|
|---|
| Research Collaborator |
YAMAMOTO TETSUYA 東京都立産業技術高等専門学校, ものづくり工学科, 教授 (00259839)
SASAKI SATOSHI 東京工科大学, 応用生物学部, 教授 (70262110)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
|---|
| Keywords | 細胞 / 解糖系 / 振動反応 / 同期現象 / 酵母細胞 / がん細胞 / 解糖系振動 / 代謝 / 同期 / 細胞間コミュニケーション / 解糖系振動反応 / 情報伝達 / 生命機能 |
|---|
| Outline of Final Research Achievements |
This study has aimed to clarify biological function of oscillations and synchronization of organisms. We experimentally observed glycolytic oscillations in yeast cells at a single cell level, though yeasts were considered not to exhibit the oscillations above a critical cell density. Analyses of a mathematical model of glycolytic oscillations revealed that the efficiency of energy acquisition is about 7 to 8 % higher in the oscillatory glycolysis than in the stationary-state glycolysis. We also revealed that yeast cells encapsulated in alginate microparticles at a high cell-density exhibited complete synchronization in the glycolytic oscillations.Glycolytic oscillations in cervical cancer HeLa cells that have metabolic similarities with yeast cells were also observed at a single cell level for the first time.
|
