| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
As the result of extensive decoding of genome sequences, novel tools are needed for comprehensive analyses of available big sequence data. We previously developed a BLSOM, which can cluster genomic fragment sequences according to phylotype solely dependent on oligonucleotide composition. Howerver, a large-scale BLSOM needs a large computational resource.
We have developed Self-Compressing BLSOM (SC-BLSOM) for reduction of computation time, which allows us comprehensive analysis of big sequence data. The strategy of SC-BLSOM is to hierarchically construct BLSOMs according to data class such as phylotype. SC-BLSOM could be constructed faster than BLSOM and cluster the sequences according to phylotype with high accuracy. We have also developed a new method to predict protein function on the basis of similarity in oligonucleotide composition. The proteins could be related to function-known proteins. These methods are useful to analyze big sequence data for efficient knowledge discovery.
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