Information Theoretic Understanding of Autonomic Cardiac Regulation and Its Application to Medical Diagnosis

• Project/Area Number: 26330329
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Life / Health / Medical informatics
• Research Institution: Nagoya University
• Principal Investigator: Ohnishi Noboru 名古屋大学, 情報科学研究科, 研究員 (70185338)
• Co-Investigator(Kenkyū-buntansha): 工藤 博章 名古屋大学, 情報科学研究科, 准教授 (70283421)
• Research Collaborator: Barros Allan Kardec Federal University of Maranhao, 教授 ; Lucena Fausto University CEUMA
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 心拍変動 / 自律的調節機能 / 独立成分分析 / コーディングメカニズム / 計算機診断支援 / 心電図 / 独立主成分分析

Outline of Final Research Achievements

We analyzed heart rate variability obtained from RR interval of ECG by using the independent component analysis from the viewpoint of the information theory. As results, we found the difference of filter (code) distribution in time-frequency domain between healthy and non-healthy persons; uniform distribution from 0 Hz to 0.5 Hz for healthy persons while localized in low frequency of 0.15 Hz for sleep apnea and heart failure. This shows a possibility of computer aided diagnosis of cardiac failures. Also we found that the dimension of coding decreases from healthy to non-healthy. This reduction is considered as that of information processing ability of heart. Thus we have obtained useful knowledge about autonomic cardiac regulation and its medical diagnosis.

Research Products

• [Journal Article] The performance of short-term heart rate variability in the detection of congestive heart failure (2016)
  • Author(s): Fausto Lucena, Allan Kardec Barros, Noboru Ohnishi
  • Journal Title: Journal of Biomed research international Volume: 2016 Pages: 1-11
  • DOI: 10.1155/2016/1675785
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Coding Mechanisms Underlying the Genesis of the Cardiac Rhythm (2017)
  • Author(s): Fausto LUCENA, Allan KARDEC BARROS, Noboru OHNISHI
  • Organizer: 電子情報通信学会MBE研究会
  • Place of Presentation: 九州大学
  • Year and Date: 2017-01-27
• [Presentation] The Self-Organizing Capacity of the Sinoatrial Node in the Heart : An Information-Theoretic Analysis (2014)
  • Author(s): Fausto Lucena, Allan Kardec Narros, Noboru Ohnishi
  • Organizer: 日本神経回路学会第24回全国大会
  • Place of Presentation: 函館，北海道
  • Year and Date: 2014-08-27