Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Outline of Final Research Achievements |
To know the roles of iron-sulfur (FeS) cluster in DNA repair related genetic disease, we focused on the putative FeS cluster binding motif in UVSSA protein. We generated multiple mutants and found some of the mutants show sensitivity to UV.The expression levels of CIAX components in cancer cell lines were also examined. CIAX complex is up-regulated in blood cancer cell lines. In particular, CIAX complex is highly expressed in macrophage-like cells such as THP-1 and U937. The reduction of CIAX expression level does not affect phagocytosis.
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