Elucidation of the mechanisms of low dose, low dose-rate radiation induced mammary cancer through the interaction between mammary stem cells and their microenvironment
| Project/Area Number |
26340024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology (2017)
Hiroshima University (2014-2016) |
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Principal Investigator |
IIZUKA DAISUKE 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, 主任研究員(定常) (00455388)
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| Co-Investigator(Kenkyū-buntansha) |
神谷 研二 広島大学, 医療政策室, 特任教授 (60116564)
笹谷 めぐみ (豊島めぐみ / 笹谷 めぐみ(豊島めぐみ)) 広島大学, 原爆放射線医科学研究所, 准教授 (80423052)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 放射線誘発乳がん / 乳腺微小環境 / 乳腺幹細胞 / 移植実験 / 発がん実験 / FACS解析 / Mammosphere培養法 / 乳腺組織片移植 |
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| Outline of Final Research Achievements |
Epidemiological studies have suggested that the risk of breast cancer incidence in A-bomb survivors is higher than any other sites. The molecular mechanisms of low dose, low dose-rate radiation induced breast cancer have not been clearly demonstrated yet. Tissue stem cells are one of critical target for carcinogenesis. To clarify the molecular mechanisms of low dose, low dose-rate radiation induced breast cancer, we focused on the interaction between mammary stem cells and their microenvironment after radiation exposure.
We observed here that mammary stem cells were increased in a strain- and dose-rate- dependent manner when mammary gland was irradiated at 4 weeks of age. We also observed the increase of tumor growth rate in radiation chimera model, which recapitulate the direct effect of tumor induction by irradiated mammary microenvironment.
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Report
(5 results)
Research Products
(27 results)
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[Journal Article] RAD18 Activates the G2/M Checkpoint through DNA Damage Signaling to Maintain Genome Integrity after Ionizing Radiation Exposure.2015
Author(s)
Sasatani M, Xu Y, Kawai H, Cao L, Tateishi S, Shimura T, Li J, Iizuka D, Noda A, Hamasaki K, Kusunoki Y, Kamiya K.
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Journal Title
PLoS One
Volume: 10
Issue: 2
Pages: 1-16
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A novel ATM/TP53/p21-mediated checkpoint only activated by chronic γ-irradiation2014
Author(s)
CAO Lili, KAWAI Hidehiko, SASATANI Megumi, IIZUKA Daisuke, MASUDA Yuji, INABA Toshiya, SUZUKI Keiji, OOTSUYAMA Akira, UMATA Toshiyuki, KAMIYA Kenji, SUZUKI Fumio
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Journal Title
PLoS One
Volume: 9
Issue: 8
Pages: e104279-e104279
DOI
NAID
Related Report
Peer Reviewed / Open Access
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