| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Epidemiological studies have suggested that the risk of breast cancer incidence in A-bomb survivors is higher than any other sites. The molecular mechanisms of low dose, low dose-rate radiation induced breast cancer have not been clearly demonstrated yet. Tissue stem cells are one of critical target for carcinogenesis. To clarify the molecular mechanisms of low dose, low dose-rate radiation induced breast cancer, we focused on the interaction between mammary stem cells and their microenvironment after radiation exposure.
We observed here that mammary stem cells were increased in a strain- and dose-rate- dependent manner when mammary gland was irradiated at 4 weeks of age. We also observed the increase of tumor growth rate in radiation chimera model, which recapitulate the direct effect of tumor induction by irradiated mammary microenvironment.
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