Age-dependent effects on radiation-induced carcinogenesis in rat thyroid
| Project/Area Number |
26340026
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中島 正洋 長崎大学, 原爆後障害医療研究所, 教授 (50284683)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 甲状腺濾胞上皮細胞 / ラット / 放射線 / 発がん / オートファジー / DNA損傷応答 / 甲状腺濾胞上皮 |
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| Outline of Final Research Achievements |
To clarify the age-dependent effects to radiation-induced thyroid carcinogenesis, we examined the incidence of radiation-induced thyroid tumor, the change of DNA damage response, the expression of autophagy-related molecule of tumor tissue of immature 4-week old (4W), adult 4-month (4M), and 7 month (7M) rats after 8 Gy X-ray irradiation. The incidence of thyroid tumor was 0, 14.3 and 16.7 % in non-irradiated, and 61.9, 63.6 and 33.3 % in irradiated 4W, 4M and 7M rats respectively. It has been found that the various types of thyroid tumor were occurred multiple in young irradiated rats. At 1 month, the number of 53BP1 foci, cell death and proliferating cells of irradiated group in young rats were higher than non-irradiated rats, and at 12 month these value was decreased to control level in both group. The expression of LC3 and p62 in the poorly differentiated carcinoma and the gene expression of Atg5 and Atg4b in medullary carcinoma of young irradiated rats were decreased.
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Report
(4 results)
Research Products
(24 results)
