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Age-dependent effects on radiation-induced carcinogenesis in rat thyroid

Research Project

Project/Area Number 26340026
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Risk sciences of radiation and chemicals
Research InstitutionNagasaki University

Principal Investigator

MATSUYAMA Mutsumi  長崎大学, 原爆後障害医療研究所, 助教 (00274639)

Co-Investigator(Kenkyū-buntansha) 中島 正洋  長崎大学, 原爆後障害医療研究所, 教授 (50284683)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords甲状腺濾胞上皮細胞 / ラット / 放射線 / 発がん / オートファジー / DNA損傷応答 / 甲状腺濾胞上皮
Outline of Final Research Achievements

To clarify the age-dependent effects to radiation-induced thyroid carcinogenesis, we examined the incidence of radiation-induced thyroid tumor, the change of DNA damage response, the expression of autophagy-related molecule of tumor tissue of immature 4-week old (4W), adult 4-month (4M), and 7 month (7M) rats after 8 Gy X-ray irradiation. The incidence of thyroid tumor was 0, 14.3 and 16.7 % in non-irradiated, and 61.9, 63.6 and 33.3 % in irradiated 4W, 4M and 7M rats respectively. It has been found that the various types of thyroid tumor were occurred multiple in young irradiated rats. At 1 month, the number of 53BP1 foci, cell death and proliferating cells of irradiated group in young rats were higher than non-irradiated rats, and at 12 month these value was decreased to control level in both group. The expression of LC3 and p62 in the poorly differentiated carcinoma and the gene expression of Atg5 and Atg4b in medullary carcinoma of young irradiated rats were decreased.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (24 results)

All 2017 2016 2015 2014 Other

All Journal Article (7 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) (of which Int'l Joint Research: 2 results) Book (3 results) Remarks (2 results)

  • [Journal Article] ラット放射線誘発甲状腺がんと年齢影響2016

    • Author(s)
      4.松山睦美、入船 理、七條和子、松田勝也、三浦史郎、関根一郎、中島正洋
    • Journal Title

      広島医学

      Volume: 69(4) Pages: 307-310

    • Related Report
      2016 Annual Research Report
  • [Journal Article] ラット放射線誘発甲状腺がんの年齢影響とオートファジー関連遺伝子の発現解析2016

    • Author(s)
      5.松山睦美、川副靖晃、七條和子、松田勝也、三浦史郎、中島正洋
    • Journal Title

      長崎医学

      Volume: 91(特別号) Pages: 271-274

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Effect of age on the sensitivity of the rat thyroid gland to ionizing radiation.2015

    • Author(s)
      Matsuu-Matsuyama M, Shichijo K, Okaichi K, Kurashige T, Kondo H, Miura S, Nakashima M
    • Journal Title

      J Radiation Research

      Volume: 56 Issue: 3 Pages: 1-9

    • DOI

      10.1093/jrr/rrv003

    • NAID

      120006987061

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cancer stem cell theory and intratumor heterogeneity in thyroid carcinogenesis (Review)2015

    • Author(s)
      Nakashima M, Shimamura M, Yasui K, Mitsutake N, Matsuu-Matsuyama M, Matsuda K, Nagayama Y
    • Journal Title

      Journal of Basic and Clinical Medicine

      Volume: 4 Pages: 8-12

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cancer Stem Cell Theory and Intratumor Heterogeneity in Thyroid Carcinogenesis2015

    • Author(s)
      Nakashima M, Shimamura M, Yasui K, Mitsutake N, Matsuu-Matsuyama M, Matsuda K, Nagayama Y
    • Journal Title

      Journal of Basic & Clinical Medicine

      Volume: 4 Pages: 8-12

    • Related Report
      2014 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] ラット甲状腺濾胞上皮の放射線誘発腫瘍に対する年齢影響とオートファジーの関与2014

    • Author(s)
      松山睦美、徳永瑛子、蔵重智美、七條和子、松田勝也、三浦史郎、関根一郎、中島正洋
    • Journal Title

      広島医学

      Volume: 67 Pages: 347-351

    • Related Report
      2014 Research-status Report
  • [Journal Article] ラット甲状腺濾胞上皮の放射線腫瘍に対する年齢影響とオートファジーの関与(第2報)2014

    • Author(s)
      松山睦美、七條和子、松田勝也、赤澤祐子、三浦史郎、関根一郎、中島正洋
    • Journal Title

      長崎医学会雑誌

      Volume: 89 Pages: 306-309

    • Related Report
      2014 Research-status Report
  • [Presentation] アミノ酸混合物シスチン・テアニンの放射線防護効果:急性小腸障害への影響2017

    • Author(s)
      松山睦美、七條和子、近藤久義、土屋誉、米田純也、松田勝也、三浦史郎、関根一郎、中島正洋
    • Organizer
      第106回日本病理学会総会
    • Place of Presentation
      新宿京王プラザ(東京都新宿区)
    • Year and Date
      2017-04-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 若齢及び高齢ラット放射線誘発甲状腺がんのオートファジー関連遺伝子の発現解析2016

    • Author(s)
      松山睦美、七條和子、松田勝也、三浦史郎、中島正洋
    • Organizer
      第59回日本放射線影響学会
    • Place of Presentation
      JMSアステールプラザ(広島県・広島市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 放射線誘発甲状腺発がんリスク亢進への年齢影響解析2016

    • Author(s)
      松山睦美、七條和子、松田勝也、三浦史郎、中島正洋
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-05-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] 放射線誘発甲状腺発がんリスク亢進への年齢影響解析2016

    • Author(s)
      松山睦美、七條和子、松田勝也、三浦史郎、中島正洋
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2016-05-12
    • Related Report
      2015 Research-status Report
  • [Presentation] ラット放射線誘発甲状腺がんの年齢影響とオートファジー関連遺伝子の発現解析2016

    • Author(s)
      8.松山睦美、川副靖晃、七條和子、松田勝也、三浦史郎、中島正洋
    • Organizer
      第57回原子爆弾後障害研究会
    • Place of Presentation
      原爆資料会館(長崎県・長崎市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Age-dependent effects on radiation-induced thyroid carcinogenesis in rats2015

    • Author(s)
      Matsuu-Matsuyama M, Shichijo K, Matsuda K, Okaichi K, Miura S, Nakashima M
    • Organizer
      One Health Conference in Nagasaki
    • Place of Presentation
      長崎大学医学部良順会館(長崎市)
    • Year and Date
      2015-11-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラット放射線誘発甲状腺癌の分子病理2015

    • Author(s)
      中島正洋、松山睦美、松田勝也
    • Organizer
      第19回日本内分泌病理学会学術総会
    • Place of Presentation
      アバンセ佐賀(佐賀市)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
  • [Presentation] ラット放射線誘発甲状腺がんと年齢影響2015

    • Author(s)
      松山睦美、入舩 理、七條和子、松田勝也、三浦史郎、関根一郎、中島正洋
    • Organizer
      第56回原子爆弾後障害研究会
    • Place of Presentation
      広島国際会議場(広島市中区)
    • Year and Date
      2015-06-07
    • Related Report
      2015 Research-status Report
  • [Presentation] Age-dependent effects on radiation-induced carcinogenesis in rat thyroid2015

    • Author(s)
      Mutsumi Matsuyama, Kazuko Shichijo, Katsuya Matsuda, Kumio Okaichi, Tomomi Kurashige, Shiro Miura, Masahiro Nakashima
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      Kyoto International Conference Center (Kyoto)
    • Year and Date
      2015-05-25 – 2015-05-29
    • Related Report
      2014 Research-status Report
  • [Presentation] Age-dependent effects on radiation-induced carcinogenesis in rat thyroid2015

    • Author(s)
      Matsuyama M, Shichijo K, Matsuda K, Okaichi K, Kurashige T, Miura S, Nakashima M
    • Organizer
      The 15th International Congress of Radiation Research
    • Place of Presentation
      京都国際会議場(京都市左京区)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラット甲状腺の急性期の放射線応答に対する年齢影響2015

    • Author(s)
      松山睦美、七條和子、岡市協生、蔵重智美、三浦史郎、関根一郎、中島正洋
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Year and Date
      2015-04-30 – 2015-05-02
    • Related Report
      2014 Research-status Report
  • [Presentation] ラット甲状腺の急性期の放射線応答に対する年齢影響2015

    • Author(s)
      松山睦美、七條和子、岡市協生、蔵重智美、三浦史郎、関根一郎、中島正洋
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Research-status Report
  • [Book] 内分泌系 岩田隆子監修 わかりやすい病理学(改訂第6版)2016

    • Author(s)
      中島正洋
    • Publisher
      南江堂
    • Related Report
      2016 Annual Research Report
  • [Book] 新版 放射線医学科-生命と放射線・電磁波・超音波-2016

    • Author(s)
      中島正洋
    • Publisher
      医療科学社
    • Related Report
      2016 Annual Research Report
  • [Book] 病理と臨床33(1)2015

    • Author(s)
      中島正洋
    • Publisher
      文光堂
    • Related Report
      2015 Research-status Report
  • [Remarks] 長崎大学原爆後障害医療研究所 腫瘍・診断病理学研究分野(原研病理)

    • URL

      http://www-sdc.med.nagasaki-u.ac.jp/pathology/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 長崎大学原爆後障害医療研究所 腫瘍・診断病理学研究分野(原研病理)

    • URL

      http://www-sdc.med.nagasaki-u.ac.jp/pathology/index.html

    • Related Report
      2015 Research-status Report 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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