| Project/Area Number |
26340030
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Toyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宮西 伸光 東洋大学, 食環境科学部, 教授 (80372720)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 銀ナノ粒子 / メダカ / 糖鎖 / 免疫 / 生態リスク / 銀ナノコロイド / 魚病菌 / 感染 |
|---|
| Outline of Final Research Achievements |
Ecotoxicity of nanomaterials is one of the international concerns. Silver nanoparticles, which account for about half of the international market as health and hygiene products, are considered to be one of the most ecological risk chemicals, since they have antibacterial activity in particular. In this study, we investigated the influence of silver nanocolloid (SNC), which is considered to be frequently used as silver nanoparticles, on embryo development and on innate immunity to medaka. From analyses of microarray and quantitative PCR, gene expressions related to immunity, biological defense mucosa etc. were disrupted by SNC exposure. Infection experiments with Edwardsiella tarda revealed that the infection of medaka adults increased due to SNC exposure.
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