The role of thyroid hormone function in different brain regions during brain development and the development of novel methods to measure the effect of environmental chemicals.
| Project/Area Number |
26340036
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Kanagawa University of Human Services (2015-2016)
Gunma University (2014) |
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Principal Investigator |
IWASAKI Toshiharu 神奈川県立保健福祉大学, 保健福祉学部, 教授 (80375576)
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| Co-Investigator(Kenkyū-buntansha) |
鯉淵 典之 群馬大学, 大学院医学系研究科, 教授 (80234681)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 甲状腺ホルモン / 環境化学物質 / 脳発達 / コファクター / 初代培養 / 遺伝子改変動物 / cofactor |
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| Outline of Final Research Achievements |
To study the effect of thyroid hormone (TH) and its receptor (TR) during brain development, we analyzed the hypo-thyroid model animals including transgenic mice expressing a mutant human TR specifically in cerebellar Purkinje cells. These mice showed abnormal cerebellar morphogenesis and motor coordination defect.
We also investigated the effect of environmental chemicals during brain development including developmental origins of health and disease (DOHaD). We analyzed not only environmental chemicals but also soy bean polyphenols and gadolinium-based contrast agents. We found that each chemical showed different effects through different pathways to the brain function. We found that PFOS may disrupt dendrite arbolization through a system other than genomic pathway.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Possible involvement of IGF-1 signaling on compensatory growth of the infraspinatus muscle induced by the supraspinatus tendon detachment of rat shoulder2014
Author(s)
Ichinose T, Lesmana R, Yamamoto A, Kobayashi T, Shitara H, Shimoyama D, Takatsuru Y, Iwasaki T, Shimokawa N, Takagishi K, Koibuchi N
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Journal Title
Physiological Rep
Volume: 2
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Altered cerebellum development and dopamine distribution in a rat genetic model with congenital hypothyroidism.2014
Author(s)
Shimokawa N, Yousefi B, Morioka S, Yamaguchi S, Ohsawa A, Hayashi H, Azuma A, Mizuno H, Kasagi M, Masuda H, Jingu H, Furudate SI, Haijima A, Takatsuru Y, Iwasaki T, Umezu M, Koibuchi N.
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Journal Title
J Neuroendocrinol.
Volume: 26
Issue: 3
Pages: 164-175
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines.2014
Author(s)
Yamazaki H, Kojima N, Kato K, Hirose E, Iwasaki T, Mizui T, Takahashi H, Hanamura K, Roppongi RT, Koibuchi N, Sekino Y, Mori N, Shirao T.
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Journal Title
J Neurochem.
Volume: 128
Issue: 4
Pages: 507-522
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Early life exposure of perfluorooctane sulfonate causes cerebellar dysfunction possibly through suppression of iodothyronin deiodenase 2 activity.2017
Author(s)
Iwasaki T, Kuribara H, Haijima A, Miyasaka Y, Araki O, Lu Yu, Amano I, Takatsuru Y, Shimokawa N, Murakami M, Koibuchi N.
Organizer
第94回日本生理学会大会
Place of Presentation
浜松
Year and Date
2017-03-28
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