Research Project
Grant-in-Aid for Scientific Research (C)
As oxygen is consumed in brain, reactive oxygen species are generated and are predicted to be a cause of alzheimer disease. In this research, we studied oxidation of RNA and removal of the oxidative RNA.Human Auf1 protein, a oxidative RNA specific binding protein, was examined whether it had roles in the induction of apoptosis. It was found that Auf1 protein played a role in oxidative RNA degradation. In cells lacking Auf1 protein, apoptosis was repressed. In yeast, Gtr1 protein was found to be involved in excretion of ROS.
All 2017 2016 2015
All Journal Article (3 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 3 results, Open Access: 3 results, Acknowledgement Compliant: 1 results) Presentation (16 results) (of which Int'l Joint Research: 2 results, Invited: 1 results)
Scientific Reports
Volume: 6 Issue: 1 Pages: 31714-31714
10.1038/srep31714
Free Radic. Biol. Med.
Volume: 99 Pages: 385-391
10.1016/j.freeradbiomed.2016.08.018
Free Radic Biol Med.
Volume: 79 Pages: 109-116
10.1016/j.freeradbiomed.2014.11.018
