Assessment of Health Effect Induced by Chemicals Contained in Ambient Dust on Asthma Patients and Development of Its Preventive Method

• Project/Area Number: 26340048
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental impact assessment
• Research Institution: Kanazawa University
• Principal Investigator: Michigami Yoshimasa 金沢大学, 環境保全センター, 准教授 (90190678)
• Co-Investigator(Kenkyū-buntansha): 神林 康弘 金沢大学, 医学系, 講師 (20345630) ; 中村 裕之 金沢大学, 医学系, 教授 (30231476)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 大気粉塵 / 重金属 / 多環芳香族炭化水素類 / 慢性咳嗽 / 咳 / PM2.5 / IgE / 気管支喘息 / 金属 / 微小粒子状物質（PM2.5） / 総浮遊粒子状物質（TSP） / 多環芳香族炭化水素類（PAH） / 遷移金属 / 眼のかゆみ / 一般化推定方程式 / 大気汚染 / アレルギー

Outline of Final Research Achievements

The health effect of ambient dust including Asian dust and PM2.5 becomes a social issue. In this study, we showed that heavy metals contained in ambient dust were associated with aggravation of symptoms (itchy eye, cough) of adult chronic cough (bronchial asthma, cough variant asthma, atopic cough) patients. The aggravation of symptoms by heavy metals was stronger in patients whose serum IgE level were low. It was suggested that the effect of heavy metals on symptoms of chronic cough patients is stronger in patients whose allergy symptoms were weak.
Constituent of heavy metals was different between total suspended particulate and PM2.5. Especially, the concentrations of heavy metals contained in total suspended particulate became higher, but the concentrations of some heavy metals contained in PM2.5 were not changed in Asian dust days. When the health effect of particulate matters is considered, it is important to take account of their constituent.

Research Products

• [Journal Article] Association of cough prevalence in non-asthma adult patients with ambient polycyclic aromatic hydrocarbons, nitrogen and sulhpur dioxide: A longitudinal study (2016)
  • Author(s): Anyenda EO, Higashi T, Kambayashi Y, Nguyen TTT, Michigan Y, et al.
  • Journal Title: Int J Environ Res Public Health Volume: 13(8) Pages: 800-800
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Exposure to daily ambient particulate polycyclic aromatic hydrocarbons and cough occurrence in adult chronic cough patients (2016)
  • Author(s): Anyenda EO, Higashi T, Kambayashi Y, Nguyen TTT, Michigan Y, et al.
  • Journal Title: Atmos Environ Volume: 140 Pages: 34-41
  • DOI: 10.1016/j.atmosenv.2016.05.042
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A Longitudinal Study of Association between Heavy Metals and Itchy Eyes, Coughing in Chronic Cough Patients: Related with Non-Immunoglobulin E Mediated Mechanism (2016)
  • Author(s): Thao Thi Thu Nguyen , Tomomi Higashi , Yasuhiro Kambayashi , Enoch Olando Anyenda , Yoshimasa Michigami , Johsuke Hara , Masaki Fujimura , Hiromasa Tsujiguchi , Masami Kitaoka , Hiroki Asakura , Daisuke Hori , Yuri Hibino, Tadashi Konoshita and Hiroyuki Nakamura
  • Journal Title: Int. J. Environ. Res. Public Health Volume: 13 Issue: 1 Pages: 110-123
  • DOI: 10.3390/ijerph13010110
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Exacerbation of daily cough and allergic symptpms in adult patients with chronic cough by Asian dust: A hospital-based study in Kanazawa (2014)
  • Author(s): Higashi T, Kambayashi Y, Ohkura N, Fujimura M, Nakanishi S, Yoshizaki T, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Hitomi Y, and Nakamura H
  • Journal Title: Atmospheric Environment Volume: in press Pages: 537-543
  • DOI: 10.1016/j.atmosenv.2014.01.041
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Asian dust on daily cough occurrence in patients with chronic cough: A panel study. (2014)
  • Author(s): Higashi T, Kambayashi Y, Ohkura N, Fujimura M, Nakai S, Honda Y, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Anyenda EO, Hitomi Y, Nakamura H.
  • Journal Title: Atmospheric Environment Volume: 92 Pages: 506-513
  • DOI: 10.1016/j.atmosenv.2014.04.034
  • NAID: 120005463354
  • Peer Reviewed / Open Access
• [Presentation] 大気粒子状物質中PAHやPM2.5やSO2と成人慢性咳嗽患者における咳症状との関連 (2015)
  • Author(s): Anyenda Enoch Olando、神林康弘、東朋美、Nguyen Thi Thu Thao、道上義正、他
  • Organizer: 第13回日本予防医学会学術総会
  • Place of Presentation: フレンドパーク石川
  • Year and Date: 2015-06-20
• [Presentation] 慢性咳嗽患者における重金属と目のかゆみと咳との関連 IgEレベルによる違い (2015)
  • Author(s): Nguyen Thi Thu Thao、神林康弘、東朋美、Anyenda Enoch Olando、道上義正、他
  • Organizer: 第13回日本予防医学会学術総会
  • Place of Presentation: フレンドパーク石川
  • Year and Date: 2015-06-20
• [Presentation] 越境大気汚染の慢性咳嗽への影響評価 (2014)
  • Author(s): 東朋美、神林康弘、藤村正樹、早川和一、西條清史、杉本伸夫、中井里史、本田靖、小林史尚、人見嘉哲、中村裕之
  • Organizer: 第55回大気環境学会年会 健康・影響分科会
  • Place of Presentation: 愛媛大学
  • Year and Date: 2014-09-17 – 2014-09-19
• [Presentation] 黄砂と慢性咳嗽に関する疫学研究 (2014)
  • Author(s): 東朋美、神林康弘、藤村正樹、西條清史、早川和一、杉本伸夫、中井里史、本田靖、人見嘉哲、中村裕之
  • Organizer: 第84回日本衛生学会学術総会シンポジウム
  • Place of Presentation: 岡山コンベーションセンター
  • Year and Date: 2014-05-25 – 2014-05-27