Predicting changes in aquatic toxicity of chemicals resulting from solvent or dispersant use as vehicle
| Project/Area Number |
26340087
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental risk control and evaluation
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| Research Institution | Kanagawa Institute of Technology |
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Principal Investigator |
Kikuchi Mikio 神奈川工科大学, 応用バイオ科学部, 名誉教授 (70308534)
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| Co-Investigator(Kenkyū-buntansha) |
澤井 淳 神奈川工科大学, 応用バイオ科学部, 教授 (80288216)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 生態毒性 / 毒性 / 化学物質 / ミジンコ類 / 魚類 / 吸着 / 濃縮性 / 生態毒性試験 / 界面活性剤 / 陽性対照 / 助剤 / 遺伝毒性・生態毒性 / 濃縮率 |
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| Outline of Final Research Achievements |
In aquatic toxicity testing of poorly water-soluble substances, it can be difficult to prepare a concentrated stock solution and maintain a constant exposure concentration in the water. These cases typically involve preparation of the concentrated stock solution in a water-miscible organic solvent or a surface-active dispersant as a vehicle. It is necessary to select an appropriate type and concentration of vehicle prior to toxicity testing, as a substance's toxicity measured using a vehicle can differ from that of the substance alone. The purposes of this study is to develop a methodology for predicting the influence of vehicle on toxicity of test substances.
The adsorption changes on silicone film of a test substance by using vehicle was closely correlated with the changes in toxicity. The adsorption test and physicochemical properties of a substance can predict toxicity changes of the substance by using vehicle. The usefulness of our method was inspected by the published data.
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Report
(4 results)
Research Products
(4 results)
