| Project/Area Number |
26350109
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Chubu University |
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Principal Investigator |
KUSANO Yuri 中部大学, 応用生物学部, 准教授 (90432252)
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| Research Collaborator |
TAKEUCHI Wakako
TSUJIHARA Nobuko
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| Project Period (FY) |
2014-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ジオスゲニン / 骨格筋 / AMPK / 細胞融合 / 筋線維 / ジネンジョ / 脂質代謝 / 細胞分化 / 植物ステロール / エネルギー代謝 / 細胞増殖・細胞分化 |
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| Outline of Final Research Achievements |
The present study investigated the effects of dietary diosgenin, which is a steroid sapogenin, on lipid metabolism and skeletal muscle. As a result, we found that supplementation with diosgenin led not only to both a significant elevation of HDL-cholesterol concentration and inhibition of visceral fat accumulation, but also to expansion of skeletal muscle fibers in the rats. Furthermore, using mouse myoblast-derived C2C12 cells, it was demonstrated that diosgenin induced skeletal muscle cell differentiation by promoting fusion of myoblasts and promoted phosphorylation of AMP kinase in myotubes.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究によりジオスゲニンが骨格筋に与える生理作用を、細胞レベルでの解析結果を伴って、提示することができた。運動不足が「死亡に対する危険因子」に挙げられているが、得られたこれらの成果は、運動時に骨格筋において得られるエネルギー消費の亢進作用及び筋線維の増大・増加作用を示すものと考えている。ジオスゲニンは一部のヤマノイモ属等に多く含まれることから、食品中の機能性成分として期待できる成果が得られたのではないかと考えている。
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