| Project/Area Number |
26350117
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Nara Women's University |
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Principal Investigator |
Morimoto Keiko 奈良女子大学, 生活環境科学系, 教授 (30220081)
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| Co-Investigator(Kenkyū-buntansha) |
小城 勝相 放送大学, 教養学部, 教授 (10108988)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | エストロゲン / 高脂肪食 / 口腔内脂肪酸感受性 / 脂肪嗜好性 / 月経周期 / 閉経後女性 / 卵巣摘出ラット / 脂肪酸受容体 / 閉経 / 中高年女性 / 体脂肪率 / 肥満 / 脂肪酸感受性 |
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| Outline of Final Research Achievements |
We examined whether menstrual phases and menopause influence oral fat taste perception, fat preference, and fat intake in young and middle-aged women. Oral detection thresholds for oleic acid varied cyclically, with decrease in the periovulatory phase. In addition, menopause increased the threshold. These findings suggest that oral sensitivity to oleic acid varies depending on ovarian hormones.
In addition, we investigated the effects of estradiol replacement on high-fat diet intake via fat sensing pathway in ovariectomized (OVX) rats. In placebo-treated (Pla) rats, energy intake and body weight were increased after the high fat diet (HFD), while these were decreased in the estradiol-treated (E2) rats. Estradiol replacement suppressed the HFD intake of 30 min only after an administration of lipid emulsion to oral cavity. Plasma cholecystokinin (CCK) was increased in E2 compared with Pla group. These results suggest that estradiol may inhibit HFD intake via CCK secretion in OVX rats.
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