| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Folate deficiency during pregnancy has been proposed to be associated to increase the risk of neonatal tube defect. It is also reported that maternal malnutrition increases the risk of life-style related diseases in adulthood. We revealed previously that folate deficiency changes the expression of lipid metabolism-related genes, and accumulate triglyceride in liver. In this study, we investigated the effect of maternal folate deficiency on lipid metabolism in the offspring. Maternal folate deficiency suppressed the gain of body weight in the offspring. Moreover, this induced increase of white adipose tissue, accumulation of triglyceride in liver, and impairment in down-regulation of genes related to fatty acid synthesis in the offspring which intake high-fat diet after weaning. These results suggest that maternal folate deficiency affect on lipid metabolism in the offspring.
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