| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To determine the correlation between deviated food habit and diseases with adipose inflammation, Psmb8-deficient mice were fed a high fat diet (HFD). The PSMB8 is reported as a causal gene for human autoimmune disease with lipodystrophy. Psmb8-deficient mice treated with HFD showed lower gain of body weight, less amount of fat tissue, and smaller number of preadipocyte in their fat tissue than that of WT mice with HFD. The Psmb8-deficient preadipocyte also had low expression levels of genes need for adipocyte maturation. Expression levels of inflammatory cytokines and number of infiltrated cells in the adipose tissue of HFD-treated mice were not significant differences between the Psmb8-deficient and -sufficient mice. These results may suggest Psmb8 molecule were necessary for development of adipose tissue, and did not affect to inflammation in mouse adipose tissue induced by HFD treatment.
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