Effect to an immune cell of new soy isoflavone for the purpose of the metabolic syndrome prevention
| Project/Area Number |
26350124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SHUTO Emi 徳島大学, 大学院医歯薬学研究部(医学系), 講師 (10512121)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | メタボリックシンドローム / 慢性炎症 / 大豆イソフラボン / イソフラボン |
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| Outline of Final Research Achievements |
Because it was reported that the T cell which was an immune cell controlled the basic condition of a patient, and the concept that various lifestyle diseases produced from chronic inflammation attracted attention of onset mechanism of the metabolic syndrome, I did it with the chronic inflammation target through a T cell concerned with the onset of the metabolic syndrome and tried that I elucidated onset mechanism of new metabolic syndrome.
After giving it, and examining Equol using a diet induced obesity mouse by the Western food of 45% of lipid energy ratios, I found that the differentiation polarity of the macrophage in the epididymis fat become the M2 predominance, and improve an insulin signal affected by a high-fat diet.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Excessive dietary phosphorus intake impairs endothelial function in young healthy men: a time- and dose-dependent study2015
Author(s)
Nishi T, Shuto E, Ogawa M, Ohya M, Nakanishi M, Masuda M, Katsumoto M, Yamanaka-Okumura H, Sakai T, Takeda E, Sakaue H, Taketani Y.
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Journal Title
The Journal of Medical Investigation
Volume: 62
Issue: 3.4
Pages: 167-172
DOI
NAID
ISSN
1343-1420, 1349-6867
Related Report
Peer Reviewed / Open Access
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