| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Acrylamide (AA) is a carcinogen in food. AA is metabolized to glycidamide (GA), more strong carcinogen, by CYP2E1. It has been reported that gene and protein expression of CYP2E1 are induced by diabetes or ingestion of alcohol. Consequently, diabetic condition or alcohol intake state may change the genotoxicity of AA. In this study, we examined the change of AA genotoxicity in diabetic condition and alcohol intake state using genotoxicity tests. Type I diabetic model mice and alcohol-ingested mice were oral-administered with AA. The micronuclei frequency in bone marrow erythrocytes and DNA damage in liver and kidney of diabetic and alcohol-ingested mice treated with AA were significantly increased compared with normal mice. It is thought that genotoxicity of AA might be increased by metabolism activation to GA with increase in expression of CYP2E1 in diabetic condition and alcohol habit.
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