New risk assessment method for chemicals in foods cosidering lifestlye disease and eating habit
| Project/Area Number |
26350125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
Masuda Shuichi 静岡県立大学, 食品栄養科学部, 准教授 (40336657)
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| Co-Investigator(Kenkyū-buntansha) |
島村 裕子 静岡県立大学, 食品栄養科学部, 助教 (60452025)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 遺伝毒性 / 生活習慣病 / 食習慣 / アクリルアミド / DNA損傷性 / 染色体異常誘発性 / 糖尿病 / アルコール / CYP2E1 / 化学物質 / 小核試験 / コメットアッセイ / 薬物代謝酵素 / 肥満 |
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| Outline of Final Research Achievements |
Acrylamide (AA) is a carcinogen in food. AA is metabolized to glycidamide (GA), more strong carcinogen, by CYP2E1. It has been reported that gene and protein expression of CYP2E1 are induced by diabetes or ingestion of alcohol. Consequently, diabetic condition or alcohol intake state may change the genotoxicity of AA. In this study, we examined the change of AA genotoxicity in diabetic condition and alcohol intake state using genotoxicity tests. Type I diabetic model mice and alcohol-ingested mice were oral-administered with AA. The micronuclei frequency in bone marrow erythrocytes and DNA damage in liver and kidney of diabetic and alcohol-ingested mice treated with AA were significantly increased compared with normal mice. It is thought that genotoxicity of AA might be increased by metabolism activation to GA with increase in expression of CYP2E1 in diabetic condition and alcohol habit.
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Report
(4 results)
Research Products
(5 results)
