| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In this study, we found the novel anti-cancer activities of food components via the inhibition of heat shock proteins. First, it has been clarified that resveratrol and/or capsaicin stop the cancer cell cycle by suppressing the expression of Hsp90, consequently leading to the inhibition of cancer cell growth. Second, we have found that curcumin and/or hesperetin exhibit the anti-cancer activity by inducing the apoptosis in cancer cells via the inhibition of Hsp70 or 14-3-3 protein.
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