• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The molecular nutritional study of relation between vitamin A level and lipid metabolism

Research Project

Project/Area Number 26350127
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionUniversity of Nagasaki

Principal Investigator

Yamaguchi Noriaki  長崎県立大学, 看護栄養学部, 助教 (80516295)

Co-Investigator(Kenkyū-buntansha) 駿河 和仁  長崎県立大学, 看護栄養学部, 准教授 (70315852)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
KeywordsビタミンA / 肥満 / 脂肪組織 / AMPK / エネルギー消費量 / ビタミンA過剰症 / 体脂肪 / エネルギー代謝 / 脂質代謝 / ビタミンA過剰摂取 / 筋肉
Outline of Final Research Achievements

Vitamin A reduces fat mass and can contribute to the prevention of obesity. In the present study, we investigated how vitamin A reduced fat mass in a high fat-diet (HFD)-induced obese mouse model. The vitamin A-treated HFD mice (VA mice) had a significant reduction in body weight and fat mass. The energy expenditure in the VA mice significantly increased with the activation of AMP-activated protein kinase α (AMPKα) in the white adipose tissue (WAT). However, the intake of vitamin A caused some typical hypervitaminosis A. We suggest that excess intake of vitamin A reduces the fat mass in HFD-induced obese mice through enhancement of energy expenditure by activation of AMPKα in the WAT.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Competitive regulation of human intestinal β-carotene 15,15'-monooxygenase 1 (BCMO1) gene expression by hepatocyte nuclear factor (HNF)-1α and HNF-4α.2014

    • Author(s)
      Yamaguchi N, Sunto A, Goda T, Suruga K.
    • Journal Title

      Life Sciences

      Volume: 119 Pages: 34-39

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] ビタミンA過剰摂取はマウスのエネルギー消費量を上昇させ体脂肪を減少させる2016

    • Author(s)
      山口範晃、駿河和仁
    • Organizer
      第70回日本栄養食糧学会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-14
    • Related Report
      2015 Research-status Report
  • [Presentation] アルコール摂取がラットのビタミンAおよびβカロテンの代謝変動に及ぼす影響2016

    • Author(s)
      西村玲泉、山口範晃、駿河和仁
    • Organizer
      第70回日本栄養食糧学会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-14
    • Related Report
      2015 Research-status Report
  • [Presentation] ビタミンA過剰摂取はマウスのエネルギー消費量を上昇させ体脂肪を減少させる2016

    • Author(s)
      山口範晃、駿河和仁
    • Organizer
      第70回日本栄養・食糧学会
    • Place of Presentation
      武庫川女子大(兵庫県西宮市)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] アルコール摂取がラットのビタミンAおよびβ-カロテンの代謝変動に及ぼす影響2016

    • Author(s)
      西村玲泉、山口範晃、駿河和仁
    • Organizer
      第70回日本栄養・食糧学会
    • Place of Presentation
      武庫川女子大(兵庫県西宮市)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] The excess intake of vitamin A increases energy expenditure, and decreases fat mass of high-fat diet induced-obese mice.2015

    • Author(s)
      Noriaki Yamaguch, Eri Abe, Kazuhito Suruga.
    • Organizer
      ACN2015
    • Place of Presentation
      横浜
    • Year and Date
      2015-05-17
    • Related Report
      2015 Research-status Report
  • [Presentation] Effects of dietary high-fat feeding on gene expression of β-carotene and retinoids metabolism-related enzymes in small intestine and liver.2015

    • Author(s)
      Sachiko Takase, Miki Igarashi, Noriaki Yamaguchi, Toshinao Goda, Kazuhito Suruga.
    • Organizer
      ACN2015
    • Place of Presentation
      横浜
    • Year and Date
      2015-05-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 乳酸発酵した長崎県産緑茶が3T3L-1細胞およびラット脂質代謝に及ぼす影響。2014

    • Author(s)
      鳥巣雄洋、金崎茜、鈴木大士、野口洋平、永田保夫、田丸靜香、山口範晃、玉屋圭、河村俊哉、田中隆、田中一成
    • Organizer
      日本食品科学工学会
    • Place of Presentation
      福岡
    • Year and Date
      2014-08-28 – 2014-08-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 授乳期の食餌制限が仔ラットのビタミンA代謝機能に及ぼす影響.2014

    • Author(s)
      駿河和仁、東坂美奈子、山下あすか、安倍絵里、山口範晃
    • Organizer
      日本栄養食糧学会
    • Place of Presentation
      北海道
    • Year and Date
      2014-05-30 – 2014-06-01
    • Related Report
      2014 Research-status Report
  • [Remarks]

    • URL

      http://sun.ac.jp/research/researcher/researcher_detail/?uid=yamaguti

    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi