Analysis of mechanisms of the effect on diabetes and gene expression induction by molecular hydrogen.
| Project/Area Number |
26350129
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Nippon Medical School |
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Principal Investigator |
KAMIMURA Naomi 日本医科大学, 先端医学研究所, 准教授 (60283800)
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| Co-Investigator(Renkei-kenkyūsha) |
OHTA Shigeo 日本医科大学, 大学院医学研究科, 准授 (00125832)
WOLF Alexander 日本医科大学, 先端医学研究所, 講師 (20434136)
IUCHI Katsuya 日本医科大学, 先端医学研究所, 助教 (40553847)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 酸化ストレス / 糖尿病 / 抗酸化剤 / 肝臓 |
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| Outline of Final Research Achievements |
We previously reported that long-term drinking of H2 -water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice. Here, the comprehensive gene expression profile in the liver of db/db mice was analyzed by DNA microarray. Pathway analyses revealed the increased expression of various genes involved in fatty acid and steroid metabolism. As a transcription pathway, the PPARα signaling pathway was identified to up-regulate their genes by ingesting H2. As an early event, the gene expression of PGC-1α was transiently increased, followed by increased expression of FGF21 and other genes. The expression of PGC-1α might be regulated indirectly through sequential regulation by H2, 4-hydroxy-2-nonenal, and Akt/FoxO1 signaling, as suggested in HepG2 cell experiments.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure2017
Author(s)
Ono T, Kamimura N, Matsuhashi T, Nagai T, Nishiyama T, Endo J, Hishiki T, Nakanishi T, Shimizu N, Tanaka H, Ohta S, Suematsu M, Ieda M, Sano M, Fukuda K, Kaneda R
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Journal Title
Sci Rep.
Volume: 7
Issue: 1
Pages: 39752-39752
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Intravenous transplantation of bone marrow-derived mononuclear cells prevents memory impairment in transgenic mouse models of Alzheimer's disease.2015
Author(s)
Kanamaru T, Kamimura N, Yokota T, Nishimaki K, Iuchi K, Lee H, Takami S, Akashiba H, Shitaka Y, Ueda M, Katsura K, Kimura K, Ohta S.
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Journal Title
Brain Res.
Volume: 1605
Pages: 49-58
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Oxidative stress accelerates amyloid deposition and memory impairment in a double-transgenic mouse model of Alzheimer's disease2015
Author(s)
Kanamaru T, Kamimura N, Yokota T, Iuchi K, Nishimaki K, Takami S, Akashiba H, Shitaka Y, Katsura K, Kimura K, Ohta S.
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Journal Title
Neurosci Lett.
Volume: 587
Pages: 126-131
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity.2014
Author(s)
Yokoyama M, Okada S, Nakagomi A, Moriya J, Shimizu I, Nojima A, Yoshida Y, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Fruttiger M, Lozano G, Minamino T.
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Journal Title
Cell Rep
Volume: 7
Issue: 5
Pages: 1691-1703
DOI
Related Report
Peer Reviewed / Open Access
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