| Project/Area Number |
26350129
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Nippon Medical School |
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Principal Investigator |
KAMIMURA Naomi 日本医科大学, 先端医学研究所, 准教授 (60283800)
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| Co-Investigator(Renkei-kenkyūsha) |
OHTA Shigeo 日本医科大学, 大学院医学研究科, 准授 (00125832)
WOLF Alexander 日本医科大学, 先端医学研究所, 講師 (20434136)
IUCHI Katsuya 日本医科大学, 先端医学研究所, 助教 (40553847)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 酸化ストレス / 糖尿病 / 抗酸化剤 / 肝臓 |
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| Outline of Final Research Achievements |
We previously reported that long-term drinking of H2 -water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice. Here, the comprehensive gene expression profile in the liver of db/db mice was analyzed by DNA microarray. Pathway analyses revealed the increased expression of various genes involved in fatty acid and steroid metabolism. As a transcription pathway, the PPARα signaling pathway was identified to up-regulate their genes by ingesting H2. As an early event, the gene expression of PGC-1α was transiently increased, followed by increased expression of FGF21 and other genes. The expression of PGC-1α might be regulated indirectly through sequential regulation by H2, 4-hydroxy-2-nonenal, and Akt/FoxO1 signaling, as suggested in HepG2 cell experiments.
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