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Analysis of Molecular Mechanism of Fetal Origin of Adult Diseases using C.elegans.

Research Project

Project/Area Number 26350134
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionKyoto Women's University

Principal Investigator

Matsumoto Shinya  京都女子大学, 家政学部, 准教授 (30263156)

Research Collaborator SAITO Haruka  
OGAI Midori  
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsC.elegans / starvation / FOAD / DOHaD / Caenorhabditis elegans / 成人病胎児期起源説 / 線虫 / エピジェネティクス / 飢餓 / 成人病胎児起源説
Outline of Final Research Achievements

Low-birth weight resulted from intrauterine growth retardation is thought to be a risk factor of adult diseases such as diabetes, obesity and cardiovascular disfunction according to the Fetal Origin of Adult Diseases Theory. However, how the intrauterine growth retardation leads the infant susceptible to adulthood disease is not well understood. We have shown that when C.elegans, a widely used experimental model of multi-cellular organism, was deprived of food, their progeny accumulated more fat than their counterpart, indicating C.elegans can be a good model for analyzing Fetal Origin of Adult Diseases Theory.
We have shown that genes involved in methylation of certain lysine residues in H3 histone are differentially expressed in worms derived from starvation-experienced worms compared to those of worms derived from fed-worms. Our result indicates that epigenetic modification in histone may be responsible for Fetal Origin of Adult Diseases Theory.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] 飢餓が雄性体線虫の生殖能力に及ぼす影響2014

    • Author(s)
      福田仁美,小池なつみ,松本晋也
    • Journal Title

      京都女子大学食物学会誌

      Volume: 69 Pages: 25-31

    • NAID

      120005620778

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] C.elegansを用いた生活習慣病胎児期起源説のエピジェノティクス解析2018

    • Author(s)
      磯部芙久子、坂上美登理、西田彩乃、岡田嵯和子、下地頭所理美、齋藤春佳、清 愛、森下真有、山本佳苗、宮前さつき、榎 陽香、松本晋也
    • Organizer
      日本農芸化学会名古屋大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線虫を用いた繰り返し絶食が生体に及ぼす影響の検討2017

    • Author(s)
      松本 晋也,山本 玲奈,山本 佳苗,長尾 美咲,佐藤 奈央,山本 さゆり,澤永 朱里
    • Organizer
      日本農芸化学会京都大会
    • Place of Presentation
      京都
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] Repeated Starvation leads fat accumulation in C.elegans2017

    • Author(s)
      Shinya Matsumoto, Rena Yamamoto, Kanae Yamamoto, Misaki Nagao, Nao Sato, Yukari Yamamoto, Akari Sawanaga
    • Organizer
      21st International C.elegans Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of intergenerational effects of starvation.2015

    • Author(s)
      Shinya Matsumoto, Haruka Saito, Midori Ogai, Mayu Morishita, Megumi Sei, Sawako Okada, Ayano Nishida, Akari Sawanaga, Midori Sakagami, Kosuke Kato, Yasuki Matsumura
    • Organizer
      20th International C.elegans Meeting
    • Place of Presentation
      UCLA(Los Angeles) USA
    • Year and Date
      2015-07-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 線虫を用いた分子栄養学的アプローチ2015

    • Author(s)
      松本晋也
    • Organizer
      2015年日本農芸化学会大会
    • Place of Presentation
      岡山大学(岡山市)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 線虫CD36の低温応答への関与2015

    • Author(s)
      小粥みどり,太田夕貴,澤田理奈,谷口芙美,岡松麻衣,桑原未季,田中江来,片岡愛理,土肥奈津子,弥谷智代,加藤康介,松本晋也
    • Organizer
      2015年日本農芸化学会大会
    • Place of Presentation
      岡山大学(岡山市)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 飢餓体験が次世代に及ぼす影響について線虫を用いた解析2015

    • Author(s)
      斎藤春佳,森下真有,清 愛,岡田嵯和子,下地頭所理美,西田彩乃,坂上美登理,松村康生,村上 博,松本晋也
    • Organizer
      2015年日本農芸化学会大会
    • Place of Presentation
      岡山大学(岡山市)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of Repeated Starvation on Fat Content2014

    • Author(s)
      Shinya Matsumoto
    • Organizer
      The 6th Asia-Pacific C.elegans Meeting
    • Place of Presentation
      Nara,Japan
    • Year and Date
      2014-07-15 – 2014-07-19
    • Related Report
      2014 Research-status Report
  • [Book] 食べ物と健康2015

    • Author(s)
      松本晋也 他20名
    • Total Pages
      286
    • Publisher
      南江堂
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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