Analysis of Molecular Mechanism of Fetal Origin of Adult Diseases using C.elegans.
| Project/Area Number |
26350134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Kyoto Women's University |
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Principal Investigator |
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| Research Collaborator |
SAITO Haruka
OGAI Midori
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | C.elegans / starvation / FOAD / DOHaD / Caenorhabditis elegans / 成人病胎児期起源説 / 線虫 / エピジェネティクス / 飢餓 / 成人病胎児起源説 |
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| Outline of Final Research Achievements |
Low-birth weight resulted from intrauterine growth retardation is thought to be a risk factor of adult diseases such as diabetes, obesity and cardiovascular disfunction according to the Fetal Origin of Adult Diseases Theory. However, how the intrauterine growth retardation leads the infant susceptible to adulthood disease is not well understood. We have shown that when C.elegans, a widely used experimental model of multi-cellular organism, was deprived of food, their progeny accumulated more fat than their counterpart, indicating C.elegans can be a good model for analyzing Fetal Origin of Adult Diseases Theory.
We have shown that genes involved in methylation of certain lysine residues in H3 histone are differentially expressed in worms derived from starvation-experienced worms compared to those of worms derived from fed-worms. Our result indicates that epigenetic modification in histone may be responsible for Fetal Origin of Adult Diseases Theory.
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Report
(5 results)
Research Products
(10 results)
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[Presentation] Analysis of intergenerational effects of starvation.2015
Author(s)
Shinya Matsumoto, Haruka Saito, Midori Ogai, Mayu Morishita, Megumi Sei, Sawako Okada, Ayano Nishida, Akari Sawanaga, Midori Sakagami, Kosuke Kato, Yasuki Matsumura
Organizer
20th International C.elegans Meeting
Place of Presentation
UCLA(Los Angeles) USA
Year and Date
2015-07-24
Related Report
Int'l Joint Research
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