Instruction effect of the oral immunization generosity with the allergenic oral administration in the allergic model mouse
| Project/Area Number |
26350137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
Takahashi Kyoko 武庫川女子大学, 生活環境学部, 教授 (50175428)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 食物アレルギー / 卵アレルギー / 低減化ボーロ / アレルギーモデルマウス / 卵アレルゲン / 経口免疫寛容 / オボムコイド |
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| Outline of Final Research Achievements |
As a result of having made rapid acquired tolerance on an allergic model mouse in 2014, the allergic symptom was not improved and showed a tendency to aggravation in some biomarker. As a result of having taken long-term oral immunization therapy using the antigen addition feed to an allergic model mouse in 2915~2016, 1% antigen addition feed made an allergy symptom relieved. Acquired tolerance determined what was induced as a result that children with serious egg allergy received the egg bolo long-term oral immunization therapy that we used a low allergen (they performed it through study period) when we continued an antigen even if it was low capacity and took it in.
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Report
(4 results)
Research Products
(13 results)
