A study of neuronal mechanisms underlying overconsumption of highly preferred taste stimuli under chronic mild stress
| Project/Area Number |
26350146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YASOSHIMA Yasunobu 大阪大学, 大学院人間科学研究科, 准教授 (00273566)
INUI Tadashi 大阪大学, 大学院人間科学研究科, 助教 (40324735)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 過食 / 扁桃体 / 味覚嗜好性 / ストレスホルモン / 情動 / ストレス / 新奇恐怖 / 味覚嫌悪学習 / CRF |
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| Outline of Final Research Achievements |
Systemic injections of yohimbine, an α-adrenoceptor antagonist, selectively increase the consumption of a highly preferred sweet liquid food but not the normal chow in rats. Temporary inactivation of the basolateral nucleus of the amygdala by a pharmacological treatment abolished the facilitatory intake of a preferred food by yohimbine. Since yohimbine is known to evoke a mild stress, it is suggested that neural circuits including the basolateral nucleus of the amygdala have a pivotal role for overconsumption of highly preferred food under a weak stress condition in general.
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Report
(4 results)
Research Products
(19 results)
