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A study of neuronal mechanisms underlying overconsumption of highly preferred taste stimuli under chronic mild stress

Research Project

Project/Area Number 26350146
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionOsaka University

Principal Investigator

SHIMURA Tsuyoshi  大阪大学, 人間科学研究科, 教授 (80150332)

Co-Investigator(Renkei-kenkyūsha) YASOSHIMA Yasunobu  大阪大学, 大学院人間科学研究科, 准教授 (00273566)
INUI Tadashi  大阪大学, 大学院人間科学研究科, 助教 (40324735)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords過食 / 扁桃体 / 味覚嗜好性 / ストレスホルモン / 情動 / ストレス / 新奇恐怖 / 味覚嫌悪学習 / CRF
Outline of Final Research Achievements

Systemic injections of yohimbine, an α-adrenoceptor antagonist, selectively increase the consumption of a highly preferred sweet liquid food but not the normal chow in rats. Temporary inactivation of the basolateral nucleus of the amygdala by a pharmacological treatment abolished the facilitatory intake of a preferred food by yohimbine. Since yohimbine is known to evoke a mild stress, it is suggested that neural circuits including the basolateral nucleus of the amygdala have a pivotal role for overconsumption of highly preferred food under a weak stress condition in general.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (19 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 4 results) Presentation (13 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] 美味しさ・不味さの脳機構2017

    • Author(s)
      志村 剛
    • Journal Title

      生産と技術

      Volume: 69 Pages: 76-78

    • NAID

      40021057885

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 味覚嫌悪学習の想起におけるラット扁桃体基底外側核の役割―接近・摂取行動の微細分析―2015

    • Author(s)
      乾 賢, 志村 剛
    • Journal Title

      日本味と匂学会誌

      Volume: 22 Pages: 269-272

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 中脳吻側内側被蓋核は味覚嫌悪学習の消去に関与する2015

    • Author(s)
      須永 佑, 乾 賢, 志村 剛
    • Journal Title

      日本味と匂学会誌

      Volume: 22 Pages: 297-300

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 扁桃体の一時的不活性化による味覚性新奇恐怖の減弱2015

    • Author(s)
      米倉野超, 乾 賢, 志村 剛
    • Journal Title

      日本味と匂学会誌

      Volume: 22 Pages: 305-308

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A mouse model for binge-like sucrose overconsumption: Contribution of enhanced motivation for sweetener consumption.2015

    • Author(s)
      Yasoshima, Y., Shimura, T.
    • Journal Title

      Physiology & Behavior

      Volume: 138 Pages: 154-164

    • DOI

      10.1016/j.physbeh.2014.10.035

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 味の好き嫌い2014

    • Author(s)
      志村 剛
    • Journal Title

      日本医師会雑誌

      Volume: 142 Pages: 2612-2612

    • Related Report
      2014 Research-status Report
  • [Presentation] Ultrasonic vocalizations in rats accompanied by chemical stimuli-induced emotional behaviors2016

    • Author(s)
      Terashima A, Shimura T
    • Organizer
      17th International Symposium on Olfaction and Taste
    • Place of Presentation
      Pacifico Yokohama
    • Year and Date
      2016-06-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The role of the neural projections from the basolateral amygdala to the bed nucleus of the stria terminalis on the retrieval of conditioned taste aversion2016

    • Author(s)
      Inui T, Shimura T
    • Organizer
      17th International Symposium on Olfaction and Taste
    • Place of Presentation
      Pacifico Yokohama
    • Year and Date
      2016-06-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Interaction between taste and olfactory signals of a diurnally delivered palatable food contributes to shift to daytime feeding patterns in mice2016

    • Author(s)
      Yasoshima,Y, Shimura T
    • Organizer
      17th International Symposium on Olfaction and Taste
    • Place of Presentation
      Pacifico Yokohama
    • Year and Date
      2016-06-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 味覚嫌悪学習想起時の行動表出におけるラット扁桃体基底外側核ニューロンとその遠心性投射路の機能2016

    • Author(s)
      乾 賢, 志村 剛
    • Organizer
      日本生理学会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 味覚性運動反応による情動評価2016

    • Author(s)
      志村 剛
    • Organizer
      第2回口腔神経科学研究会
    • Place of Presentation
      大阪大学大学院歯学研究科
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 味覚嫌悪学習の想起におけるラット扁桃体基底外側核の役割―接近・摂取行動の微細分析―2015

    • Author(s)
      乾 賢, 志村 剛
    • Organizer
      日本味と匂学会
    • Place of Presentation
      岐阜市じゅうろくプラザ
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 中脳吻側内側被蓋核は味覚嫌悪学習の消去に関与する2015

    • Author(s)
      須永 佑, 乾 賢, 志村 剛
    • Organizer
      日本味と匂学会
    • Place of Presentation
      岐阜市じゅうろくプラザ
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 扁桃体の一時的不活性化による味覚性新奇恐怖の減弱2015

    • Author(s)
      米倉野超, 乾 賢, 志村 剛
    • Organizer
      日本味と匂学会
    • Place of Presentation
      岐阜市じゅうろくプラザ
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 分界条床核へのGABAA受容体阻害薬および作動薬の注入が味覚嫌悪学習の想起に及ぼす影響2015

    • Author(s)
      乾 賢, 志村 剛
    • Organizer
      日本神経科学学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 分界条床核のGABAA受容体をブロックすると条件性嫌悪味溶液の摂取がさらに抑制される2015

    • Author(s)
      乾 賢, 志村 剛
    • Organizer
      日本生理学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 味覚嫌悪学習の想起における接近-回避コンフリクト2014

    • Author(s)
      日本味と匂学会
    • Organizer
      日本味と匂学会
    • Place of Presentation
      清水文化会館マリナー卜
    • Year and Date
      2014-10-02 – 2014-10-04
    • Related Report
      2014 Research-status Report
  • [Presentation] むちゃ食い様過剰摂取行動を示すマウスでは血中ペプチドYY濃度が低下する2014

    • Author(s)
      山口恵里菜, 八十島安伸, 志村 剛
    • Organizer
      日本神経科学学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 高嗜好食の呈示時刻に同調した摂食亢進における視床下部背内側核の関与2014

    • Author(s)
      八十島安伸, 志村 剛
    • Organizer
      日本神経科学学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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