Effects of odor components of spices on the digestive muscle activities

• Project/Area Number: 26350147
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Nagasaki University
• Principal Investigator: NIHEI Zenro 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (00189341)
• Co-Investigator(Kenkyū-buntansha): 木本 万里 日本女子大学, 家政学部, 教授 (60101565) ; 戸田 一雄 長崎大学, 医歯薬学総合研究科(歯学系), 名誉教授 (80134708)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 香辛料 / 山椒 / 嗅覚 / 回腸 / 平滑筋運動 / 性差 / ラット / 香気成分 / 消化管運動 / 食欲 / 腸管

Outline of Final Research Achievements

It is well known that some spices have potential effects on the regulation of digestive system. For example, these are critical components in Kampo medicine. Previous studies were concentrated on the direct effects of these spices, few studies exist on the odor components effects on the digestive movements. We investigated effects of odor components of the spices (ginger,wasabi,sansho) on the ileal smooth muscle activities in Wistar rats. During inhalation of sansho odor, spontaneous ileal activities were not changed,however,amplitudes of the electrical evoked muscle contraction (5V,5Hz,5s) were clearly increased. There were no effects on the ileal muscle activities during inhalation of the other spices. Sex differences were also observed in sansho effects. In female rats,the sansho-induced effects were greater than those in male rats. It is suggested that odor effect of the spices is useful to modulate digestive activities, although it is weaker rather than direct one.

Research Products

• [Int'l Joint Research] University of Brasilia(ブラジル)
• [Journal Article] Body site-dependent changes in pain threshold during the estrous cycle in rats (2015)
  • Author(s): Yamashita, H., Zeredo, J. L., Kimoto, M., Nihei, Z., Asahina, I., Kaida, K., Toda, K.
  • Journal Title: Psychology & Neuroscience Volume: 9 Pages: 414-422
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Sex differences in ileal somatostatin-response after stress conditioning in rats (2015)
  • Author(s): Kimoto, M., Zeredo, J. L., Ota, M. S., Nihei, Z., Toda, K.
  • Journal Title: Journal of Food and Nutrition Sciences Volume: 3 Pages: 1-4
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Ginger-induced ileal motility is modified by stress: Sex differences in rats (2015)
  • Author(s): Kimoto, M., Zeredo, J. L., Ota, M. S., Nihei, Z., Toda, K.
  • Journal Title: Journal of Food and Nutrition Sciences Volume: 3 Pages: 5-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sansho intake modulates ileum activity in stress-loaded rats (2015)
  • Author(s): Kimoto, M., Zeredo, J. L., Ota, M. S., Nihei, Z., Toda, K.
  • Journal Title: Journal of Food and Nutrition Sciences Volume: 3 Pages: 9-12
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sex Differences in Ileal Somatostatin-Response after Stress Conditioning in Rats (2015)
  • Author(s): Mari Kimoto, Jorge L. Zeredo, Masato S. Ota, Zenro Nihei, Kazuo Toda
  • Journal Title: Journal of Food and Nutrition Sciences Volume: 3(3-1) Issue: 3 Pages: 1-4
  • DOI: 10.11648/j.jfns.s.2015030301.11
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ginger-induced Ileal Motility is Modified by Stress: Sex Differences in Rats (2015)
  • Author(s): Mari Kimoto, Jorge L. Zeredo, Masato S. Ota, Zenro Nihei, Kazuo Toda
  • Journal Title: Journal of Food and Nutrition Sciences Volume: 3(3-1) Issue: 3 Pages: 5-8
  • DOI: 10.11648/j.jfns.s.2015030301.12
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Effects of daily Sansho intake on the ileum activities in stress-loaded rats (2015)
  • Author(s): Kimoto,M.,Zeredo,J.L., Yamashita,H.,Kaida,K., Ota,M.O., Nihei, Z., Toda,K.
  • Organizer: European Brain and Behaviour Society & European Behavioural Pharmacology Society Joint Meeting,
  • Place of Presentation: Verona, Italy
  • Year and Date: 2015-09-21
  • Int'l Joint Research
• [Presentation] Stress modified nociceptive responses in the anterior cingulate neurons during estrous cycle in female rats (2015)
  • Author(s): Yamashita,H., Zeredo,J.L., Nihei,Z., Kaida, K., Kimoto,M., Toda,K.
  • Organizer: European Brain and Behaviour Society & European Behavioural Pharmacology Society Joint Meeting
  • Place of Presentation: Verona, Italy
  • Year and Date: 2015-09-21
  • Int'l Joint Research
• [Presentation] Stress-induced modulation of ileal motility in Capsici fructus-fed female rats (2014)
  • Author(s): Mari Kimoto, Jorge L Zeredo, Zenro Nihei, Masato S Ota, Hiromi Yamashita, Kei Kaida, Kazuo Toda
  • Organizer: FEPS 2014(欧州生理学会）
  • Place of Presentation: Budapest(Hungary)
  • Year and Date: 2014-08-27 – 2014-08-30
• [Presentation] Anterior cingulate responses evoked by mechanical nociceptive stimulation in female rats (2014)
  • Author(s): Hiromi Yamashita, Jorge L Zeredo, Zenro Nihei, Kei Kaida, Mari Kimoto, Masahiro Umeda, Izumi Asahina, Kazuo Toda
  • Organizer: FEPS 2014(欧州生理学会）
  • Place of Presentation: Budapest(Hungary)
  • Year and Date: 2014-08-27 – 2014-08-30