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Effect of functional marine flavonoid on muscle atrophy

Research Project

Project/Area Number 26350148
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionNagasaki University

Principal Investigator

HIRASAKA Katsuya  長崎大学, 水産・環境科学総合研究科(水産), 助教 (70432747)

Co-Investigator(Kenkyū-buntansha) 二川 健  徳島大学, 大学院医歯薬学研究部(医学系), 教授 (20263824)
Co-Investigator(Renkei-kenkyūsha) TACHIBANA Katsuyasu  長崎大学, 水産・環境科学総合研究科(水産), 教授 (20171712)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords保健機能食品 / マリンフラボノイド / 加齢 / 筋萎縮 / ユビキチンリガーゼ
Outline of Final Research Achievements

In this study, we found flavonoid, morin in brown algae. Next, we examined the effect of dietary marine flavonoid containing morin, on the wasting of muscle. The wet weight and myofiber size of skeletal muscle in tumor-bearing mice, which is known to muscle atrophy model, significantly decreased, compared with that of vehicle-injected control mice. In contrast, the wet weight and myofiber size of skeletal muscle in tumor-bearing mice fed the marine flavonoid diet were nearly the same as those in vehicle-injected control mice. Moreover, treatment of marine flavonoid in C2C12 myotube inhibited myotube atrophy induced by tumor. These results suggest that dietary marine flavonoid suppresses muscle wasting in tumor-bearing mice. Thus, marine flavonoid may be efficacious in a therapeutic approach against the wasting of muscle.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (26 results)

All 2016 2015 2014 Other

All Journal Article (13 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 13 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Remarks (2 results)

  • [Journal Article] Dietary Supplementation with Isoflavones Prevents Muscle Wasting in Tumor-Bearing Mice2016

    • Author(s)
      Hirasaka K*, Saito S, Yamaguchi S, Miyazaki R, Wang Y, Haruna M, Taniyama S, Higashitani A, Terao J, Nikawa T, Tachibana K
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 62 Issue: 3 Pages: 178-184

    • DOI

      10.3177/jnsv.62.178

    • NAID

      130005253104

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preventive effect of dietary quercetin on disuse muscle atrophy by targeting mitochondria in denervated mice2016

    • Author(s)
      Mukai R, Matsui N, Fujikura Y, Matsumoto N, Hou DX, Kanzaki N, Shibata H, Horikawa M, Iwasa K, Hirasaka K, Nikawa T, Terao J
    • Journal Title

      J Nutr Biochem

      Volume: 31 Pages: 67-76

    • DOI

      10.1016/j.jnutbio.2016.02.001

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Capric Acid Up-Regulates UCP3 Expression without PDK4 Induction in Mouse C2C12 Myotubes2016

    • Author(s)
      Abe T, Hirasaka K, Kohno S, Tomida C, Haruna M, Uchida T, Ohno A, Oarada M, Teshima-Kondo S, Okumura Y, Choi I, Aoyama T, Terao J, Nikawa T*.
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 62 Issue: 1 Pages: 32-39

    • DOI

      10.3177/jnsv.62.32

    • NAID

      130005148603

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-obesity effects of enzymatically-digested alginate oligomer in mice model fed a high-fat-diet2016

    • Author(s)
      Nakazono S, Cho K, Isaka S, Abu R, Yokose T, Murata M, Ueno M, Tachibana K, Hirasaka K, Kim D, Oda T
    • Journal Title

      Bioactive Carbohydrates and Dietary Fibre

      Volume: 7 Issue: 2 Pages: 1-8

    • DOI

      10.1016/j.bcdf.2016.02.001

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion2016

    • Author(s)
      Hirasaka K, Mills EM, Haruna M, Bando A, Ikeda C, Abe T, Kohno S, Nowinski SM, Lago CU, Akagi K, Tochio H, Ohno A, Teshima-Kondo S, Okumura Y, Nikawa T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 472 Issue: 1 Pages: 108-113

    • DOI

      10.1016/j.bbrc.2016.02.075

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Structural analysis of the TKB domain of ubiquitin ligase Cbl-b complexed with its small inhibitory peptide, Cblin2016

    • Author(s)
      Ohno A, Ochi A, Maita N, Ueji T, Bando A, Nakao R, Hirasaka K, Abe T, Teshima-Kondo S, Nemoto H, Okumura Y, Higashibata A, Yano S, Tochio H, Nikawa T
    • Journal Title

      Arch Biochem Biophys

      Volume: 594 Pages: 1-7

    • DOI

      10.1016/j.abb.2016.02.014

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel myogenic function residing in the 5’ non-coding region of Insulin receptor substrate-1 (Irs-1) transcript.2015

    • Author(s)
      Nagano H, Yamagishi N, Tomida C, Yano C, Aibara K, Kohno S, Abe T, Ohno A, Hirasaka K, Okumura Y, Mills EM, Nikawa T, Teshima-Kondo S.
    • Journal Title

      BMC Cell Biol

      Volume: in press Issue: 1 Pages: 1-10

    • DOI

      10.1186/s12860-015-0054-8

    • NAID

      120006859993

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The malignant progression effects of regorafenib in human colon cancer cells2015

    • Author(s)
      Tomida C, Aibara K, Yamagishi N, Yano C, Nagano H, Abe T, Ohno A, Hirasaka K, Nikawa T, Teshima-Kondo S
    • Journal Title

      The Journal of Medical Investigation

      Volume: 62 Issue: 3.4 Pages: 195-198

    • DOI

      10.2152/jmi.62.195

    • NAID

      130005099146

    • ISSN
      1343-1420, 1349-6867
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of dietary soy protein on skeletal muscle volume and strength in humans with various physical activities2015

    • Author(s)
      Hashimoto R, Sakai A, Murayama M, Ochi A, Abe T, Hirasaka K, Ohno A, Teshima-Kondo S, Yanagawa H, Yasui N, Inatsugi M, Doi D, Takeda M, Mukai R, Terao J, Nikawa T
    • Journal Title

      The Journal of Medical Investigation

      Volume: 62 Issue: 3.4 Pages: 177-183

    • DOI

      10.2152/jmi.62.177

    • NAID

      130005099151

    • ISSN
      1343-1420, 1349-6867
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevention of skeletal muscle atrophy in vitro using anti-ubiquitination oligopeptide carried by atelocollagen2015

    • Author(s)
      Kawai N, Hirasaka K, Maeda T, Haruna M, Shiota C, Ochi A, Abe T, Kohno S, Ohno A, Teshima-Kondo S Mori H, Tanaka E, Nikawa T
    • Journal Title

      Biochim Biophys Acta Molecular Cell Research

      Volume: 1853 Issue: 5 Pages: 873-880

    • DOI

      10.1016/j.bbamcr.2015.01.024

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] N-Myristoylated ubiquitin ligase Cbl-b inhibitor prevents on glucocorticoid-induced atrophy in mouse skeletal muscle.2015

    • Author(s)
      Ochi A, Abe T, Nakao R, Yamamoto Y, Kitahata K, Takagi M, Hirasaka K, Ohno A, Teshima-Kondo S, Taesik G, Choi I, Kawamura T, Nemoto H, Mukai R, Terao J, Nikawa T.
    • Journal Title

      Arch Biochem Biophys

      Volume: 570 Pages: 23-31

    • DOI

      10.1016/j.abb.2015.02.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chronic exposure of VEGF inhibitors promotes the malignant phenotype of colorectal cancer cells2015

    • Author(s)
      Tomida C, Yamagishi N, Aibara K, Yano C, Uchida T, Abe T, Ohno A, Hirasaka K, Nikawa T, Teshima-Kondo S.
    • Journal Title

      The Journal of Medical Investigation

      Volume: 62 Issue: 1.2 Pages: 75-79

    • DOI

      10.2152/jmi.62.75

    • NAID

      130005129700

    • ISSN
      1343-1420, 1349-6867
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in the pericellular connective tissue and breaking strength of the three types of muscles of the cultured carp Cyprinus carpio during storage in ice.2014

    • Author(s)
      4.Liang J, Miyazaki R, Zhao X, Hirasaka K, Taniyama S, Tachibana K.
    • Journal Title

      Fisheries Science

      Volume: 80 Pages: 1083-1088

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] ユビキチンリガーゼを介した筋萎縮の分子メカニズムと機能性食品によるその予防法2016

    • Author(s)
      平坂勝也
    • Organizer
      第62回日本宇宙航空環境医学会大会 日本宇宙生物科学会第30回大会 合同大会
    • Place of Presentation
      愛知医科大学たちばなホール(愛知県長久手市)
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 微小重力環境下における筋萎縮の分子メカニズムと栄養素によるその予防法2016

    • Author(s)
      平坂勝也
    • Organizer
      日本農芸化学会2016年度西日本支部大会
    • Place of Presentation
      長崎大学文教キャンパス 環境科学部・教養教育講義棟(長崎県長崎市)
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] ロコモティブ・メタボリックシンドローム予防のための栄養学的アプローチ2016

    • Author(s)
      平坂勝也
    • Organizer
      第26回 体力・栄養・免疫学会大会
    • Place of Presentation
      長崎大学文教キャンパス文教スカイホール(長崎県長崎市)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Dietary flavonoids prevent ubiquitin ligases-mediated muscle wasting in tumor-bearing mice2016

    • Author(s)
      Katsuya Hirasaka, Takeshi Nikawa, Yao Wang, Takayuki Uchida, Reiko Nakao Shigeto Taniyama, Katsuyasu Tachibana
    • Organizer
      「Molecular Mechanisms Modulating Skeletal Muscle Development and Homeostasis in Health and Disease」conference
    • Place of Presentation
      Asilomar Conference Grounds, Pacific Grove, CA, USA
    • Year and Date
      2016-06-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 食事性イソフラボン摂取はカヘキシーによる筋萎縮を予防する2016

    • Author(s)
      髙木麻理奈、平坂勝也、齋藤志伸、宮﨑里帆、谷山茂人、橘勝康、二川健
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      武庫川女子大学(兵庫県西宮市)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] IGF-1シグナル経路の活性化を介した廃用性筋萎縮予防法2016

    • Author(s)
      平坂勝也、山田明徳、内田貴之、中尾玲子、二川健
    • Organizer
      第30回宇宙環境利用シンポジウム
    • Place of Presentation
      宇宙航空研究機構 宇宙科学研究所 相模原キャンパス(神奈川県相模原市)
    • Year and Date
      2016-01-19
    • Related Report
      2015 Research-status Report
  • [Presentation] カヘキシーによる筋萎縮に対するフラボノイド類の効果2015

    • Author(s)
      平坂勝也、齋藤志伸、宮﨑里帆、谷山茂人、二川健、橘勝康
    • Organizer
      平成27年度 日本栄養・食糧学会九州・沖縄支部大会
    • Place of Presentation
      沖縄県市町村自治会館(沖縄県那覇市)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
  • [Presentation] Dietary flavonoid intake prevents muscle wasting in tumor-bearing mice2015

    • Author(s)
      Katsuya Hirasaka, Shinobu Saito, Saki Yamaguchi, Riho Miyazaki, Shigeto Taniyama, Takeshi Nikawa, Katsuyasu Tachibana
    • Organizer
      第69回日本栄養・食糧学会大会、12th Asian Congress of Nutrition
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] これからの食品機能研究をリードするための米国での分子栄養学に関する在外研究2015

    • Author(s)
      平坂 勝也
    • Organizer
      平成27年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学品川キャンパス(東京都港区)
    • Year and Date
      2015-03-27 – 2015-03-31
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 廃用性筋萎縮に対する食品中フラボノイド類の阻害効果2014

    • Author(s)
      平坂勝也、春名真里江、安倍知紀、真板綾子、近藤茂忠、宮崎里帆、谷山茂人、橘勝康、二川健
    • Organizer
      日本宇宙生物科学会・第28回大会
    • Place of Presentation
      大阪府立大学・中百舌鳥キャンパス学術交流会館(大阪府堺市)
    • Year and Date
      2014-09-22 – 2014-09-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 廃用性筋萎縮予防に関する分子栄養学的研究2014

    • Author(s)
      平坂 勝也
    • Organizer
      第68回日本栄養・食糧学会大会
    • Place of Presentation
      札幌市教育文化会館大ホール(北海道札幌市)
    • Year and Date
      2014-05-30 – 2014-06-01
    • Related Report
      2014 Research-status Report
    • Invited
  • [Remarks] 長崎大学水産科学領域 研究室紹介

    • URL

      http://www.fe.nagasaki-u.ac.jp/intro/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 長崎大学教員個人業績

    • URL

      http://research.jimu.nagasaki-u.ac.jp/IST?ISTActId=FINDJPDetail&ISTKidoKbn=&ISTErrorChkKbn=&ISTFormSetKbn=&ISTTokenChkKbn=&userId=100000917

    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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