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Development of in vitro absorption evaluation method for practical application of included functional food and practical study on new complex

Research Project

Project/Area Number 26350156
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionOsaka City University

Principal Investigator

Doe Matsumi  大阪市立大学, 大学運営本部, 技術職員 (90433317)

Co-Investigator(Renkei-kenkyūsha) MORIMOTO Yoshiki  大阪市立大学, 大学院理学研究科, 教授 (90244631)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords機能食品 / 分子包接
Outline of Final Research Achievements

Toward the establishment of the in vitro absorption rating system for inclusion functional food in order to use practically, I found that a comparison of the diffusion coefficients of each proton of the α-lipoic acid /γ-CD complex, as the model compound, by the NMR was effective for the first time.
By a competing experiment using the equilibrium of the meeting in the water solution and the non-meeting (an inclusion state and controlled release state), I found a strong controlled release effect to the glycocholate which there was to a digestive system as well as some organic solvents, such as DMSO and pyridine.These results led to construction of model in the digestion and absorption system line.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (22 results)

All 2018 2017 2016 2015 2014

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Formal total synthesis of histrionicotoxin alkaloids via Hg(Otf)2-catalyzed cycloisomerization and SmI2-induced ring expansion2018

    • Author(s)
      Kunihiro Matsumura, Keisuke Nishikawa, Hiroaki Yoshida, Matsumi Doe, Yoshiki Morimoto
    • Journal Title

      RSC advances

      Volume: 8 Pages: 11296-11303

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mass Analytical Division, Analytical Center, Graduate School of Science, Osaka City University2017

    • Author(s)
      Matsumi Doe
    • Journal Title

      Journal of the Mass Spectrometry Society of Japan

      Volume: 66(1) Pages: 36-42

    • NAID

      130006350307

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Syntheses of Lepadiformine Marine Alkaloids with Enantiodivergency, Utilizing Hg(OTf)2-Catalyzed Cycloisomerization Reaction and their Cytotoxic Activities2017

    • Author(s)
      K. Nishikawa, K. Yamauchi, S. Kikuchi, S. Ezaki, T. Koyama, H. Nokubo, K. Matsumura, T. Kodama, M. Kumagai, and Y. Morimoto,
    • Journal Title

      Chem. Eur. J.

      Volume: 23 Issue: 40 Pages: 9535-9545

    • DOI

      10.1002/chem.201701475

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Evaluation of 5,6-Dehydrokawain Analogs as Osteogenic Inducers2017

    • Author(s)
      M. Kumagai, K. Nishikawa, T. Mishima, I. Yoshida, M. Ide, K. Koizumi, M. Nakamura, and Y. Morimoto,
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Pages: 2401-2406

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of the Cytotoxic Marine Triterpenoid Isodehydrothyrsiferol Reveals Partial Enantiodivergency in the Thyrsiferol Family of Natural Products2017

    • Author(s)
      A.Hoshino, H. Nakai, M. Morino, K. Nishikawa, T. Kodama, K. Nishikibe, and Y. Morimoto
    • Journal Title

      Angew. Chem., Int. Ed.

      Volume: 56 Pages: 3064-3068

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Chemical Engineering Education by the Practical Training Program for Utilizing the Nuclear Magnetic Resonance Appatus2016

    • Author(s)
      Matsumi Doe, Yoshiyuki URUMA, Hideo Iio
    • Journal Title

      Journal of Japanese Society for Engneering Education

      Volume: 64(4) Pages: 64-69

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analytical Center in Scienece Department of Osaka City University2016

    • Author(s)
      Matsumi Doe
    • Journal Title

      Bulletin of the Nuclear Magnetic Resonance Society of Japan

      Volume: 7 Pages: 103-105

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 1.A New Screen for Tuberculosis Drug Candidates Utilizing a Luciferase-Expressing Recombinant Mycobacterium bovis Bacillus Calmette-Guéren.2015

    • Author(s)
      Ozeki Y, Igarashi M, Doe M, Tamaru A, Kinoshita N, Ogura Y, Iwamoto T, Sawa R, Umekita M, Enany S, Nishiuchi Y, Osada-Oka M, Hayashi T, Niki M, Tateishi Y, Hatano M, Matsumoto S.
    • Journal Title

      PLoS One

      Volume: 10(11) Issue: 11 Pages: 1-28

    • DOI

      10.1371/journal.pone.0141658

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Studies on the Radical Scavenging Ability and Antimicrobial Activity of Ferulic Acid and Glycoside2015

    • Author(s)
      Yoshiyuki Uruma, Priscilla Yoong Mei Yen, Kaho Sawada, Matsumi Doe
    • Journal Title

      Journal of Pharmaceutical, Chemical and Biological Sciences

      Volume: 4(1) Pages: 39-47

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Spirostomin, Defense Toxin of the Ciliate Spirostomum teres : Isolation, Structure Elucidation, and Synthesis2015

    • Author(s)
      Yoshinosuke Sera, Miyuki Eiraku Masaki, Matsumi Doe, Federico Buonanno, Akiko Miyake, Yoshinosuke Usuki, Hideo Iio
    • Journal Title

      Chemistry Letters

      Volume: 44 Issue: 5 Pages: 633-635

    • DOI

      10.1246/cl.150044

    • NAID

      130005067971

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019739

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 天然物ケロノブシンの全合成研究2017

    • Author(s)
      吉田友輝、三上大貴、山根大樹、松本竜弥、粳間由幸、土江松美
    • Organizer
      日本化学会 第97春季年会(2017)
    • Place of Presentation
      神奈川県横浜市(慶応義塾大学 日吉キャンパス)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 食用ホオズキ(Physalis peruviana)の未利用部位から得られたwithanolide類縁体の3T3-L1細胞脂肪蓄積抑制効果2017

    • Author(s)
      熊谷 百慶,吉田 泉,三嶋 隆,井出 将博,中村 宗知,土江 松美,西川 慶祐,森本 善樹
    • Organizer
      日本農芸化学会関西支部例会(第501回講演会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Tetrodotoxinの全合成研究2017

    • Author(s)
      武田 莉奈,荒木 勇介,丸山 高広,菊池 正峰,吉山 春香,土江 松美,西川 慶祐,森本 善樹
    • Organizer
      第47回複素環化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高水溶性糖含有光増感剤の分子設計と合成と生物活性2017

    • Author(s)
      粳間由幸、野々村拓也、Priscilla Yong Mei Yen、枝谷麻里絵、山本凌太郎、土江松美、小沼那重、岡田太
    • Organizer
      第59回天然有機化合物討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] チルシフェロール類共通骨格のエナンチオ発散現象:アプリシオールB及び22-ヒドロキシ-15(28)-デヒドロベヌスタトリオールの全合成と構造改訂2017

    • Author(s)
      錦部 健人,鴇田 百栄,滝 直人,西川 慶祐,森本 善樹
    • Organizer
      第59回天然有機化合物討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 中性水中環化反応を用いたネロリドール型セスキテルペンの全合成と構造改訂2017

    • Author(s)
      森田 健吾,橋本 統星,星野 晃大,西川 慶祐,森本 善樹
    • Organizer
      第112回有機合成シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒストリオニコトキシンの形式全合成2017

    • Author(s)
      松村 匡浩,吉田 浩明,西川 慶祐,森本 善樹
    • Organizer
      第47回複素環化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 食用ホオズキ(Physalis sp.)廃棄部より得られた3T3-L1細胞脂肪蓄積抑制物質の同定と作用機序の解明2017

    • Author(s)
      熊谷 百慶,西川 慶祐,三嶋 隆,吉田 泉,井出 将博,小泉 慶子,中村 宗知,森本 善樹
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Evaluation of the Action of the Solvent Molecules to the Weak Interaction Between the Large-sized γ-Cyclodexitrin and the Chiral Lipoic Acid2015

    • Author(s)
      Matsumi Doe, Keisuke Nishikawa, Yoshimitsu Tachi, Yoshiki Morimoto
    • Organizer
      The Internatioal Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
    • Place of Presentation
      Honolulu, Hwaii, USA (米国、ハワイ)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Diffusion Coefficient as an Evaluation Factor of Interaction and Behavior of the Each Chiral Lipoic Acid-Cyclodextrin Inclusion Complex2015

    • Author(s)
      Matsumi Doe, Keisuke Nishikawa, Yoshimitsu Tachi, Yoshiki Morimoto
    • Organizer
      12th Asian Congress of Nutrition (ACN 2015)
    • Place of Presentation
      Pacifico Yokohama  (日本、横浜)
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] α-リポ酸光学異性体/γ-シクロデキストリン包接複合体の溶液中での挙動2014

    • Author(s)
      土江松美、西川慶祐、舘祥光、森本善樹
    • Organizer
      第31回シクロデキストリンシンポジウム
    • Place of Presentation
      島根県民会館(島根県松江市)
    • Year and Date
      2014-09-11 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Practical Synthesis of blepharismone and fluorescent molecular probe, a mating inducing pheromone of Blepharisma Japonicum2014

    • Author(s)
      Yoshiyuki Uruma, Yoshinosuke Usuki, Matsumi Doe, Hideo Iio
    • Organizer
      Internatioal Symposium on Advancing the Chemical Science (ISACS 14): Challenges in Organic Chemistry
    • Place of Presentation
      Shanhai Institute of Organic Chemisry (中華人民共和国、上海)
    • Year and Date
      2014-08-07 – 2014-08-10
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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