Development of in vitro absorption evaluation method for practical application of included functional food and practical study on new complex
| Project/Area Number |
26350156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Osaka City University |
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Principal Investigator |
Doe Matsumi 大阪市立大学, 大学運営本部, 技術職員 (90433317)
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| Co-Investigator(Renkei-kenkyūsha) |
MORIMOTO Yoshiki 大阪市立大学, 大学院理学研究科, 教授 (90244631)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 機能食品 / 分子包接 |
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| Outline of Final Research Achievements |
Toward the establishment of the in vitro absorption rating system for inclusion functional food in order to use practically, I found that a comparison of the diffusion coefficients of each proton of the α-lipoic acid /γ-CD complex, as the model compound, by the NMR was effective for the first time.
By a competing experiment using the equilibrium of the meeting in the water solution and the non-meeting (an inclusion state and controlled release state), I found a strong controlled release effect to the glycocholate which there was to a digestive system as well as some organic solvents, such as DMSO and pyridine.These results led to construction of model in the digestion and absorption system line.
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Report
(5 results)
Research Products
(22 results)
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[Journal Article] Total Syntheses of Lepadiformine Marine Alkaloids with Enantiodivergency, Utilizing Hg(OTf)2-Catalyzed Cycloisomerization Reaction and their Cytotoxic Activities2017
Author(s)
K. Nishikawa, K. Yamauchi, S. Kikuchi, S. Ezaki, T. Koyama, H. Nokubo, K. Matsumura, T. Kodama, M. Kumagai, and Y. Morimoto,
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Journal Title
Chem. Eur. J.
Volume: 23
Issue: 40
Pages: 9535-9545
DOI
Related Report
Peer Reviewed
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[Journal Article] 1.A New Screen for Tuberculosis Drug Candidates Utilizing a Luciferase-Expressing Recombinant Mycobacterium bovis Bacillus Calmette-Guéren.2015
Author(s)
Ozeki Y, Igarashi M, Doe M, Tamaru A, Kinoshita N, Ogura Y, Iwamoto T, Sawa R, Umekita M, Enany S, Nishiuchi Y, Osada-Oka M, Hayashi T, Niki M, Tateishi Y, Hatano M, Matsumoto S.
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Journal Title
PLoS One
Volume: 10(11)
Issue: 11
Pages: 1-28
DOI
Related Report
Peer Reviewed / Open Access
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