| Project/Area Number |
26350160
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Jumonji University |
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Principal Investigator |
SASAKI Naho 十文字学園女子大学, 人間生活学部, 講師 (10571466)
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| Co-Investigator(Kenkyū-buntansha) |
有田 安那 十文字学園女子大学, 人間生活学部, 助手 (20518104)
志村 二三夫 十文字学園女子大学, 人間生活学部, その他 (70111523)
山崎 優子 十文字学園女子大学, 人間生活学部, 講師 (70518117)
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| Co-Investigator(Renkei-kenkyūsha) |
HASHIDA Hiroko 帝京平成大学, 健康メディカル学部, 助教 (10461766)
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| Research Collaborator |
Bui Ti Ngoc Ha
KURAWAKA Misaki
TATEHANA Haruka
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | ハーブサプリメント / 安全性評価 / 薬物代謝酵素 / 環境化学物質 / カバ / リスク評価 / 環境化学物質様作用 / CYP1A1 / CYP / カバラクトン |
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| Outline of Final Research Achievements |
The safety of herbal supplements (HS) remains uncertain, and their use occasionally bring adverse effects on the liver via hepatic drug-metabolizing system. We aimed to establish risk assessment methods to ensure safety of HS using kava (Piper methysticum) as a model substance of harmful products. In this study, we investigated the environmental chemical-like action inducing expression of CYP1A1 by analysis of interactions between herbal ingredients and CYP1A1, and measurement of enzyme activity and mRNA expression of CYP1A1 in vitro and in vivo. The results indicated that some herbal ingredients have actions similar to environmental chemical substances, and also attention must be paid to interaction between HS and environmental chemical substances. This study suggests the usefulness and validity of risk assessment methods based on environmental chemical-like action.
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