| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
The activation of the aryl hydrocarbon receptor (AhR) induced by the extracts of 60 food materials, including cereals, tubers and roots, beans, and nuts, was evaluated using a reporter gene assay. Many of the tested samples induced AhR activity; in particular, cereals, vegetables, and nuts, which contribute to a balanced diet, resulted in marked activity. The extracts of walnut and adzuki bean had an especially high AhR activity. To characterize the substances responsible for AhR activation, the constituents of the respective extracts were identified. Fourteen compounds from adzuki bean extract and 29 compounds from walnut extract were isolated and identified. Among these compounds, valoneic acid dilactone methyl ester had notable AhR activation.
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