| Project/Area Number |
26350171
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
深澤 昌史 長崎国際大学, 薬学部, 准教授 (20238439)
野嶽 勇一 長崎国際大学, 薬学部, 准教授 (30332282)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 乳酸菌 / 発酵 / バイオジェニクス / 毛髪 / 発毛 / バイオジェニックス / 食品 |
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| Outline of Final Research Achievements |
The effect of PS-B1 (a fermented product cultured from soybean milk using lactic acid bacteria) on hair growth in vivo was examined by topical application of PS-B1 on the shaved dorsal skin of 4-week-old male C57BL/6 mice. The 20% ethanol solutions which included PS-B1 (5%, 15% and 30%), PBS (30%) and soybean milk (30%), respectively, were prepared as application liquids and 50 μL of each liquid was applied to the back of mice (n=10) once a day until hair growth of all mice was completed (8 months). From the picture analysis of dorsal skin, application of PS-B1 induced earlier telogen to anagen conversion as compared to those observed the vehicle treatments. Furthermore, the increase of expression of growth factors implicated in the regulation of hair growth (FGF-2 and KGF) were found as a result of the PCR analysis of the cultivation human follicle dermal papilla cells which stimulated by PS-B1. These results suggested that PS-B1 contains hair growth promoting substances.
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