Evaluating the physiological functionality of a Japanese yam propagules by nutrigenomics

• Project/Area Number: 26350177
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Kanagawa Academy of Science and Technology
• Principal Investigator: SHINOZAKI Fumika 公益財団法人神奈川科学技術アカデミー, 未病改善食品評価法開発プロジェクト, 研究員 (00359647)
• Co-Investigator(Renkei-kenkyūsha): WATANABE Yuki 公益財団法人神奈川科学技術アカデミー, 未病改善食品評価法開発プロジェクト, 常勤準研究員 (00552126)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 食品機能性 / ニュートリゲノミクス / 遺伝子発現解析 / 自然薯ムカゴ / 機能性 / 食品機能

Outline of Final Research Achievements

Our present study investigates the functionality of Japanese yam propagules using high-fat loaded mice, with significant increase in plasma alanine-amino transferase concentration and hepatic triacylglycerol level. However, high-fat loading together with propagules suppressed the increases of these parameters. Hepatic transcriptome revealed that the ingestion of propagules mitigated fatty acid metabolic disorder, oxidative stress and ER stress. The mice fed on Japanese yam propagules may thus delay the generation of their hepatic disorder through the modulation of metabolic disorder.

Research Products

• [Journal Article] Coordinated regulation of hepatic and adipose tissue transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa species. (2016)
  • Author(s): Shinozaki F, Abe T, Kamei A, Watanabe Y, Yasuoka A, Shimada K, Kondo K, Arai S, Kumagai K, Kondo T, Abe K.
  • Journal Title: Genes Nutr. Volume: 11 Issue: 1 Pages: 1-1
  • DOI: 10.1186/s12263-016-0534-2
  • Peer Reviewed / Open Access
• [Presentation] 自然薯ムカゴ抽出物の生理的機能性について (2017)
  • Author(s): 篠崎文夏、 山下治之、亀井飛鳥、 渡部由貴、 安岡顕人 、近藤香、荒井綜一、 近藤隆 、阿部啓子
  • Organizer: 日本農芸化学会2017年大会
  • Place of Presentation: 京都女子大学
  • Year and Date: 2017-03-19
• [Presentation] 高脂肪負荷マウスへの自然薯ムカゴ投与の影響 (2015)
  • Author(s): 篠崎 文夏
  • Organizer: 日本農芸化学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2015-03-27