Quantification of bone material properties-degradation by non-contacting, nano-mechanical properties analysis
| Project/Area Number |
26350493
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Hokkaido University |
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Principal Investigator |
Sasaki Naoki 北海道大学, 先端生命科学研究院, 名誉教授 (40142202)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 生体力学 / X線回折 / 最終糖化産物 / ペントシジン / コラーゲン分子 / 赤道線反射 / 応力緩和 / 骨強度 / 骨質 / コラーゲンマトリックス / 部分加水分解 / Debye-Waller 因子 / 緩和弾性率 / 動的弾性率 / 骨コラーゲン分解 / 糖化最終産物 / 非酵素的架橋 / Debye-Waller因子 / 動的粘弾性 |
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| Outline of Final Research Achievements |
Mechanical properties and structural analysis of glycated bone specimens was performed, as a model system of aged bones. Rectangular shaped bovine femoral cortical bone specimens were treated with Ringer’s solution containing glucose for periods from 3 to 28 days. Amount of pentosidine (PS) was quantified as a function of the treated periods. The increase in PS was remarkable at 14 days of incubation, but after 28 days it changed gradual, indicating the production of PS seemed saturated there. With the increase in PS, packing of alpha-polypeptide chains in a tropo-collagen was found disordered. Such a structural change in bone collagen at the molecular level was considered to affect the macroscopic material properties of bone tissues.
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Report
(4 results)
Research Products
(27 results)
