| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Mechanical properties and structural analysis of glycated bone specimens was performed, as a model system of aged bones. Rectangular shaped bovine femoral cortical bone specimens were treated with Ringer’s solution containing glucose for periods from 3 to 28 days. Amount of pentosidine (PS) was quantified as a function of the treated periods. The increase in PS was remarkable at 14 days of incubation, but after 28 days it changed gradual, indicating the production of PS seemed saturated there. With the increase in PS, packing of alpha-polypeptide chains in a tropo-collagen was found disordered. Such a structural change in bone collagen at the molecular level was considered to affect the macroscopic material properties of bone tissues.
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