Effect of catheter ablation on sympathetic nerve activity in atrial fibrillation
| Project/Area Number |
26350497
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 心不全 / 交感神経活動 / 筋交感神経活動 |
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| Outline of Final Research Achievements |
In this project, I examined the effect of catheter ablation on muscle sympathetic nerve activity in patient with atrial fibrillation. Also I compared these effect between the patient with and without heart failure. Catheter ablation reduced muscle sympathetic nerve activity in the patient with heart failure, however, it did not change in the patient with out heart failure. Our result showed that efferent sympathetic nerve activity assessed by muscle sympathetic nerve activity is reduced by the reduction in augmented afferent sympatho-stimulating receptor in left atrium in heart failure patient. it is likely that afferent sympatho-stimulating might not be augmented in the patient without heart failure. these results indicate that catheter ablation in atrial fibrillation in heart failure might exert an additional effect on the reduction in sympathetic nerve activity, which contribute to the improvement in mortality.
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Report
(5 results)
Research Products
(13 results)
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[Journal Article] Significant association between renal 123I-metaiodobenzylguanidine scintigraphy and muscle sympathetic nerve activity in patients with hypertension2017
Author(s)
Takamura M, Murai H, Okabe Y, Okuyama Y, Hamaoka T, Mukai Y, Tokuhisa H, Inoue O, Takashima S, Kato T, Matsuo S, Usui S, Furusho H, Kaneko S.
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Journal Title
J Nucl Cardiol
Volume: Jan 9
Issue: 2
Pages: 363-371
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Single-Unit Muscle Sympathetic Nerve Activity Reflects Sleep Apnea Severity, Especially in Severe Obstructive Sleep Apnea Patients.2016
Author(s)
Hamaoka T, Murai H, Kaneko S, Usui S, Okabe Y, Tokuhisa H, Kato T, Furusho H, Sugiyama Y, Nakatsumi Y, Takata S, Takamura M.
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Journal Title
Front Physiol.
Volume: 7
Pages: 66-66
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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