| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
In this project, I examined the effect of catheter ablation on muscle sympathetic nerve activity in patient with atrial fibrillation. Also I compared these effect between the patient with and without heart failure. Catheter ablation reduced muscle sympathetic nerve activity in the patient with heart failure, however, it did not change in the patient with out heart failure. Our result showed that efferent sympathetic nerve activity assessed by muscle sympathetic nerve activity is reduced by the reduction in augmented afferent sympatho-stimulating receptor in left atrium in heart failure patient. it is likely that afferent sympatho-stimulating might not be augmented in the patient without heart failure. these results indicate that catheter ablation in atrial fibrillation in heart failure might exert an additional effect on the reduction in sympathetic nerve activity, which contribute to the improvement in mortality.
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