Mechanobiology of tumor interstitial fluid pressure, angiogenesis, lymphangiogenesis, and Extracellular Matrix (ECM)
Project/Area Number |
26350500
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biomedical engineering/Biomaterial science and engineering
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Research Institution | Okayama University |
Principal Investigator |
Inagaki Junko 岡山大学, 医歯薬学総合研究科, 助教 (90271056)
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Co-Investigator(Kenkyū-buntansha) |
廣畑 聡 岡山大学, 保健学研究科, 教授 (90332791)
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Co-Investigator(Renkei-kenkyūsha) |
NARUSE KEIJI 岡山大学, 医歯薬学総合研究科, 教授 (40252233)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | ADAMTS1 / 腫瘍内圧 / 細胞外マトリックス / 血管新生 / リンパ管新生 / マクロファージ / がん内圧 |
Outline of Final Research Achievements |
A disintegrin and metalloprotease with thrombospondin type I motifs 1 (ADAMTS1), a member of the matrix metalloproteinase family, inhibits angiogenesis and lymphangiogenesis. ADAMTS1 in endothelial cells is induced by hypoxia and mechanical stress such as blood wall shear stress. We investigated the effects of tumor interstitial fluid pressure (TIFP) on the expression of ADAMTS1 in the tumor tissues. Stromal ADAMTS1 was mainly expressed in neovascular endothelial cells. It was suggested that stromal ADAMTS1 might implicate in vascular fragility and rarefaction, and elevation of TIFP.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Gene cloning, recombinant expression, purification and characterization of L-methionine decarboxylase from Streptomyces sp. 590.2017
Author(s)
Hayashi M, Okada A, Yamamoto K, Okugochi T, Kusaka C, Kudou D, Nemoto M, Inagaki J, Hirose Yuu, Okajima T, Tamura T, Soda K, Inagaki K.
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Journal Title
J Biochem.
Volume: 161
Pages: 389-398
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Recombinant expression, molecular characterization and crystal structure of antitumor enzyme, l-lysine α-oxidase from Trichoderma viride.2015
Author(s)
Amano M, Mizuguchi H, Sano T, Kondo H, Shinyashiki K, Inagaki J, Tamura T, Kawaguchi T, Kusakabe H, Imada K, Inagaki K.
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Journal Title
J Biochem.
Volume: 157
Issue: 6
Pages: 1-11
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] ADAMTS1 inhibits lymphangiogenesis by attenuating phosphorylation of the lymphatic endothelial cell-specific VEGF receptor2014
Author(s)
Inagaki J, Takahashi K, Ogawa H, Asano K, Faruk Hatipoglu O, Cilek MZ, Obika M, Ohtsuki T, Hofmann M, Kusachi S, Ninomiya Y, Hirohata S
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Journal Title
Exp Cell Res
Volume: 323(2)
Issue: 2
Pages: 263-75
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Is Versicanolysis associated with tumor angiogenesis?2015
Author(s)
Keiichi Asano, Junko Inagaki, Yuri Shoji, Matthias Hofmann, Takashi Ohtsuki, Aya Hirata, Teruyuki Kawadi, Yoshifumi Ninomiya, Satoshi Hirohata, Toshitaka Ohashi
Organizer
第8回高度医療都市を創出する未来技術国際シンポジウム がん治療と診断のための分子標的研究最前線
Place of Presentation
岡山市(岡山大学)
Year and Date
2015-02-06
Related Report
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[Presentation] ADAMTS cleaved versican in tumor angiogenic area2014
Author(s)
Keiichi Asano, Junko Inagaki, Matthias Hofmann, Teruyuki Kawadi, Aya Hirata, Yuri Shoji, Takashi Ohtsuki, Yoshifumi Ninomiya, Satoshi Hirohata
Organizer
American Society for Matrix Biology (ASMB) 2014
Place of Presentation
Marriott Key Center, Cleveland, Ohio
Year and Date
2014-10-13 – 2014-10-15
Related Report
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[Presentation] Decreased Sox9 mRNA Expression by Cytokine Stimulation Was Ameliorated by Hyaluronan in Chondrosarcoma Cells2014
Author(s)
Takashi Ohtsuki, Satoshi Hirohata, Yuri Shoji, Keiichi Asano, Aya Hirata, Teruyuki Kawadi, Junko Inagaki, Kanae Kumagishi, Keiichiro Nishida, Toshitaka Oohashi, Aiji Ohtsuka
Organizer
American Society for Matrix Biology (ASMB) 2014
Place of Presentation
Marriott Key Center, Cleveland, Ohio
Year and Date
2014-10-13 – 2014-10-15
Related Report
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[Presentation] Perinatal Lethality in ADAMTS1 Deficient Mouse2014
Author(s)
Satoshi Hirohata, Omer F Hatipoglu, Eriko Kusunoki, Takashi Ohtsuki, Junko Inagaki, Keiichi Asano, Yuri Shoji, Teruyuki Kawadi, Aya Hirata, Mehmet Z Cilek, Yoshifumi Ninomiya
Organizer
American Society for Matrix Biology (ASMB) 2014
Place of Presentation
Marriott Key Center, Cleveland, Ohio
Year and Date
2014-10-13 – 2014-10-15
Related Report
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