Synthesis of water-soluble Irinotecan bearing symmetrically branched oligoglycerols
Project/Area Number |
26350502
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biomedical engineering/Biomaterial science and engineering
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Research Institution | The University of Tokushima |
Principal Investigator |
NEMOTO Hisao 徳島大学, 大学院医歯薬学研究部(薬学系), 准教授 (30208293)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 癌 / 有機合成 / 水溶性化 / イリノテカン / オリゴグリセロール / 抗癌剤 / 水溶性 / カンプトテシン |
Outline of Final Research Achievements |
SN38 is a basic skeleton of cancer-suspected agents, a number of derivatives have been developed and studied. A commercially available cancer-suspect agent invented in Japan, "Irinotecan", is one of them, which often have an ammonium cation moiety for their water-solubility. However, non-ionic water-soluble derivatives of SN38 has bot been developed. To design and synthesize such molecules, we examined the covalent bond formation reaction of SN38 and BGL. BGL is a glycerol oligomer, and we have now BGL003 (three glycerol units) and BGL007 (seven glycerol units). The three kinds of hybrid molecule, SN38-BGL, were synthesized. To prepare a practical amount, we developed a new preparation method for BGL, which will be published in patent soon.
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Report
(4 results)
Research Products
(2 results)
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[Journal Article] A novel benzofuran, 4-methoxybenzofuran-5-carboxamide, from Tephrosia purpurea suppressed histamine H1 receptor gene expression through a protein kinase C-δ-dependent signaling pathwa2016
Author(s)
Shill, Manik Chandra; Mizuguchi, Hiroyuki; Karmakar, Sanmoy; Kadota, Tokuya; Mukherjee, Pulok, K.; Kitamura, Yoshiaki; Kashiwada, Yoshiki; Nemoto, Hisao; Takeda, Noriaki; Fukui, Hiroyuki
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Journal Title
Int. Immunopharmacol
Volume: 30
Pages: 18-26
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Structural analysis of the TKB domain of ubiquitin ligase Cbl-b complexed with its small inhibitory peptide, Cblin2016
Author(s)
Ohno, Ayako; Ochi, Arisa; Maita, Nobuo; Ueji, Tatsuya; Bando, Aki; Nakao, Reiko; Hirasaka, Katsuya; Abe, Tomoki; Teshima-Kondo, Shigetada; Nemoto, Hisao; Okumura, Yuushi; Higashibata, Akira; Yano, Sachiko;Tochio, Hidehito; Nikawa, Takeshi
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Journal Title
Arch. Biochem. Biophys
Volume: 594
Pages: 1-7
DOI
Related Report
Peer Reviewed