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Development of a diagnostic system for sleep apnea-hypopnea syndrome using microwave radars; and dynamic analysis of heart rate variability for sleep-disordered breathing

Research Project

Project/Area Number 26350507
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionTokyo Metropolitan University

Principal Investigator

Kagawa Masayuki  首都大学東京, システムデザイン学部, 客員准教授 (70646702)

Co-Investigator(Kenkyū-buntansha) 松井 岳巳  首都大学東京, システムデザイン研究科, 教授 (50404934)
Research Collaborator TOJIMA Hirokazu  
KURITA Akira  
HASHIZUME Ayako  
YOSIDA Yuki  
SASAKI Noriyuki  
TEI Kan  
SUZUMURA Kazuki  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords睡眠時無呼吸 / マイクロ波レーダー / 非接触測定 / 心拍数変動指標 / バイタルサイン / 睡眠段階 / レーダー / 血中酸素飽和度 / 診断 / 非接触
Outline of Final Research Achievements

We developed a non-contact diagnostic system for sleep apnea-hypopnea syndrome (SAHS) that can detect apneic events without inducing stress in monitored individuals. Two radars were installed beneath the mattress to measure the vibrations of the chest and abdomen, respectively. Additionally, we proposed a technique that detects paradoxical movements by focusing on phase differences between thoracic and abdominal movements, and were able to identify three types of sleep apnea: obstructive, central, and mixed. We conducted comparative tests of radar and polysomnography on outpatients at a sleep disorder center. The radar system achieved a sensitivity of 96%, and a specificity of 100%.
We evaluated the dynamics of the heart rate variability with apneic events, LF/HF ratios began to increase 14±10 seconds after the start of obstructed sleep apnea (OSA) events.The peaks of LF/HF ratios were observed 22±12 seconds after the ends of OSA events. The average of rises in peaks was about 0.9.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2014 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 4 results) Presentation (10 results) (of which Int'l Joint Research: 3 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Non-contact diagnostic system for sleep apnea?hypopnea syndrome based on amplitude and phase analysis of thoracic and abdominal Doppler radars2016

    • Author(s)
      Masayuki Kagawa, Hirokazu Tojima, Takemi Matsui
    • Journal Title

      Medical & Biological Engineering & Computing

      Volume: 54(5) Issue: 5 Pages: 789-798

    • DOI

      10.1007/s11517-015-1370-z

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sleep Stage Estimation by Body Movement Index and Respiratory Interval Indices using Microwave Radars2015

    • Author(s)
      佐々木 紀幸、香川 正幸、鈴村 和季、松井 岳巳
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 53 Issue: 4 Pages: 209-216

    • DOI

      10.11239/jsmbe.53.209

    • NAID

      130005130428

    • ISSN
      1347-443X, 1881-4379
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An infectious disease/fever screening radar system which stratifies higher-risk patients within ten seconds using a neural network and the fuzzy grouping method.2015

    • Author(s)
      Guanghao Sun, Takemi Matsui, Yukiya Hakozaki, Shigeto Abe
    • Journal Title

      Journal of Infection

      Volume: 70(3) Issue: 3 Pages: 230-236

    • DOI

      10.1016/j.jinf.2014.12.007

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A compact and hand-held infection-screening system for use in rapid medical inspection at airport quarantine stations: system design and preliminary validation.2015

    • Author(s)
      Sun G, Miyata K, Matsuoka A, Zhao Z, Iwakami S, Kim S, Matsui T.
    • Journal Title

      Journal of Medical Engineering & Technology

      Volume: 39(3) Issue: 3 Pages: 185-90

    • DOI

      10.3109/03091902.2015.1016191

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 近赤外分光法(NIRS)を用いた口呼吸時の身体的負荷の考察-口呼吸時と鼻呼吸時の脳血流量と酸素消費量の変化の比較-2016

    • Author(s)
      宮地大陽、香川正幸、橋爪絢子,松井岳巳
    • Organizer
      日本人間工学会関東支部第22回卒業研究発表会
    • Place of Presentation
      高崎経済大学(群馬県高崎市)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脳波解析による就寝前効果音の睡眠の質への影響の考察-α波リラックス指標と皮質・視床間連携指標の活用-2016

    • Author(s)
      村上可法、香川正幸、橋爪絢子、松井岳巳
    • Organizer
      日本人間工学会関東支部第46回大会
    • Place of Presentation
      高崎経済大学(群馬県高崎市)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Heart Rate and Heart Rate Variability Monitoring during Sleep using 24-GHz Microwave Radars Located beneath the Mattress on the Bed2016

    • Author(s)
      Masayuki Kagawa, Kazuki Suzumura, Ayako Hashizume and Takemi Matsui
    • Organizer
      The eighth International Workshop on Biosignal Interpretation (BSI2016 in Osaka, Japan)
    • Place of Presentation
      International House, Osaka (Osaka Conference Center) (大阪府大阪市)
    • Year and Date
      2016-11-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sleep Stage Classification by Non-contact Vital Signs Indices using Doppler Radar Sensors2016

    • Author(s)
      Masayuki Kagawa, Kazuki Suzumura, and Takemi Matsui
    • Organizer
      The 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC2016 in Orland, USA)
    • Place of Presentation
      Orlando (USA)
    • Year and Date
      2016-08-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 非接触レーダーを用いた心拍数変動指標・体動・呼吸間隔ゆらぎ指標による睡眠段階推定2016

    • Author(s)
      鈴村和季、香川正幸、松井岳巳
    • Organizer
      日本生体医工学会第55回大会
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2016-04-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 心拍数変動指標による非接触・睡眠段階推定における可変移動平均法の提案2015

    • Author(s)
      鈴村和季、程 漢、香川正幸、橋爪絢子,松井岳巳
    • Organizer
      日本人間工学会関東支部第45回大会
    • Place of Presentation
      東京電機大学埼玉鳩ヶ谷キャンパス(埼玉県比企郡)
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 睡眠時無呼吸・低呼吸イベント発生時の心拍変動指標(HRV)ダイナミクスの解析2015

    • Author(s)
      程 漢、鈴村和季、香川正幸、橋爪絢子,松井岳巳
    • Organizer
      日本人間工学会関東支部第45回大会
    • Place of Presentation
      東京電機大学鳩ヶ谷キャンパス(埼玉県比企郡)
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
  • [Presentation] Sleep Stage Classification by Body Movement Index and Respiratory Interval Indices using Multiple Radar Sensors2015

    • Author(s)
      Masayuki Kagawa, Noriyuki Sasaki, Kazuki Suzumura, and Takemi Matsui
    • Organizer
      The 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      EMBC2015 in Milan, Italy
    • Year and Date
      2015-08-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] レーダーの振幅変化に着目した睡眠時無呼吸症候群の非接触スクリーニング装置の開発2014

    • Author(s)
      吉田雄貴、香川正幸、戸島洋一,松井岳巳
    • Organizer
      第34回医療情報学連合大会
    • Place of Presentation
      幕張メッセ国際会議場(千葉市)
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] マイクロ波レーダーを用いた睡眠時無呼吸症候群簡易検査システムの開発2014

    • Author(s)
      香川正幸、吉田雄貴、戸島洋一、松井岳巳
    • Organizer
      第53回日本生体医工学会大会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2014-06-24 – 2014-06-26
    • Related Report
      2014 Research-status Report
  • [Remarks] 首都大学東京 松井研究室 研究テーマ

    • URL

      http://www.comp.sd.tmu.ac.jp/matsui-lab/research.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 首都大学東京システムデザイン学部松井研究室 研究テーマ

    • URL

      http://www.comp.sd.tmu.ac.jp/matsui-lab/research.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 首都大学東京システムデザイン学部松井研究室ホームページ 「研究テーマ」欄

    • URL

      http://www.comp.sd.tmu.ac.jp/matsui-lab/research.html

    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 生体情報の取得装置、生体情報の取得プログラムおよび生体情報の取得方法2015

    • Inventor(s)
      松井岳巳,香川正幸,鈴村和季
    • Industrial Property Rights Holder
      松井岳巳,香川正幸,鈴村和季
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-241708
    • Filing Date
      2015-12-11
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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