A study of practical suppression method of hazardous heartbeat generations using both numerical and animal models
| Project/Area Number |
26350508
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
Yazawa Toru 首都大学東京, 理工学研究科, 客員研究員 (30106603)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 不整脈 / 死の予兆 / DFA / 心拍 / 危険脈 |
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| Outline of Final Research Achievements |
We used both animal models and numerical models. An increase of extracellular potassium ions ([K]o) was a key cause for the generation of alternans heartbeat. We found an extremely beautiful relationship between [K]o and the permeability of sodium channels (GNa): a parabolic relationship between normal heartbeat area and abnormal heartbeat area in a parameter plane. In medicine, control of K ions and Na ions must suppress ill state of the heart, i.e., alternans state.
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Report
(4 results)
Research Products
(41 results)
