| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
We used both animal models and numerical models. An increase of extracellular potassium ions ([K]o) was a key cause for the generation of alternans heartbeat. We found an extremely beautiful relationship between [K]o and the permeability of sodium channels (GNa): a parabolic relationship between normal heartbeat area and abnormal heartbeat area in a parameter plane. In medicine, control of K ions and Na ions must suppress ill state of the heart, i.e., alternans state.
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