| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Axonal injury is caused by sudden inertial loading to the head associated with rapid deformation of brain tissue, resulting in the stretching of neural axons. This study aims to clarify the relation between axonal stretch and the onset of axonal injury. To examine the influence of strain rate on the threshold for axonal injury, cultured neurons were subjected to uniaxial stretching. Axonal injury increased significantly more than strain rate of 30 /s with more than strain of 0.15 even though those formations did not depend on strain rates in cultures exposed to a strain of 0.10. To examine the influence of the strain along an axon on axonal injury axonal injury was measured at every axonal angle in the stretching direction. The axons that were parallel to stretching direction were injured the most. We proposed an experimental model that subjected an axon to more accurate strain for the measurement of action potential in single neuron before and after stretching.
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