| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
MicroRNAs are important inhibitors of mRNA translation, participate in differentiation, migration, cell proliferation, and cell death. We examined whether the removal or reduction of circulating miRNAs with apheresis for systemic lupus erythematosus patients using a microRNA array chip. We present the first report that circulating miRNAs in peripheral blood can be separated and possibly directly removed using membrane separation apheresis. Furthermore, it was presumed that the separation rate of microRNAs may depend on the size of microRNAs carrier in the peripheral blood such as exosomes and microparticles.
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