Arrhythmogenic Drug Evaluation System by Simplified Animal Experiments
| Project/Area Number |
26350520
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
Amano Akira 立命館大学, 生命科学部, 教授 (60252491)
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| Co-Investigator(Kenkyū-buntansha) |
野間 昭典 立命館大学, 生命科学部, 非常勤講師 (00132738)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 薬物誘発性不整脈 / 活動電位波形 / 心筋細胞モデル / イオンチャネル / HERG / 薬物作用 / パラメータ最適化 / 吸引電極 / 活動電気波形 |
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| Outline of Final Research Achievements |
In this research, we developed a tool to evaluate arrhythmogenic effect of drugs which is one of the most problem in drug discovery, by using cardiac cell model parameter optimization. In the system, the cardiac action potential is first measured by open chest guinea pig suction electrode. Then the action potential shape is reproduced with cardiac cell model by optimizing the ion channel permeability parameters. Finally, the changes in the ion channel permeability is used to estimate drug effect to the ion channels. From the experimental results, the drug inhibition to the ion channels of IKr, IKs and ICaL could be estimated by certain extent.
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Report
(4 results)
Research Products
(69 results)
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[Journal Article] Genetic diversity of the captive Asian tapir population in Thailand, based on mitochondrial control region sequence data and the comparison of its nucleotide structure with Brazilian tapir2016
Author(s)
Yuttamol Muangkram, Akira Amano, Worawidh Wajjwalku, Tanu Pinyopummintr, Nikorn Thongtip, Nongnid Kaolim, Manakorn Sukmak, Sumate Kamolnorranath, Boripat Siriaroonrat, Wanlaya Tipkantha, Umaporn Maikaew, Warisara Thomas, Kanda Polsrila, Kwanreaun Dongsaard, Saowaphang Sanannu, Anuwat Wattananorrasate
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Journal Title
MITOCHONDRIAL DNA
Volume: -
Issue: 4
Pages: 1-5
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Touchscreen-based visual temporal discrimination task in the behaving mouse by the constant method2016
Author(s)
Yuichiro Nomura, Jumpei Mita, Shingo Takizawa, Takuma Arimura, Shinichiro Suzuki, Shohei Ikuta, Akira Amano, Yasuhiro Tsubo, Kazuhiro Shimonomura, Yasuhiro Seya, Chieko Koike
Organizer
ARVO 2016
Place of Presentation
Seattle (USA)
Year and Date
2016-05-02
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[Presentation] The evaluation of visual temporal resolution in the behaving mouse2015
Author(s)
J. Mita, S. Yokota, S. Ikuta, S. Takizawa, Y. Nomura, T. Arimura, A. Amano, K. Shimonomura, Y. Seya, Y. Tsubo, C. Koike
Organizer
SFN annual meeting 2015
Place of Presentation
Chicago, USA
Year and Date
2015-10-15
Related Report
Int'l Joint Research
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