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Arrhythmogenic Drug Evaluation System by Simplified Animal Experiments

Research Project

Project/Area Number 26350520
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionRitsumeikan University

Principal Investigator

Amano Akira  立命館大学, 生命科学部, 教授 (60252491)

Co-Investigator(Kenkyū-buntansha) 野間 昭典  立命館大学, 生命科学部, 非常勤講師 (00132738)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords薬物誘発性不整脈 / 活動電位波形 / 心筋細胞モデル / イオンチャネル / HERG / 薬物作用 / パラメータ最適化 / 吸引電極 / 活動電気波形
Outline of Final Research Achievements

In this research, we developed a tool to evaluate arrhythmogenic effect of drugs which is one of the most problem in drug discovery, by using cardiac cell model parameter optimization. In the system, the cardiac action potential is first measured by open chest guinea pig suction electrode. Then the action potential shape is reproduced with cardiac cell model by optimizing the ion channel permeability parameters. Finally, the changes in the ion channel permeability is used to estimate drug effect to the ion channels. From the experimental results, the drug inhibition to the ion channels of IKr, IKs and ICaL could be estimated by certain extent.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (69 results)

All 2017 2016 2015 2014

All Journal Article (16 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 16 results,  Open Access: 11 results) Presentation (53 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] The novel primers for mammal species identification-based mitochondrial cytochrome b sequence: implication for reserved wild animals in Thailand and endangered mammal species in Southeast Asia.2016

    • Author(s)
      Muangkram Y, Wajjwalku W, Amano A, Sukmak M.
    • Journal Title

      Mitochondrial DNA

      Volume: - Issue: 1 Pages: 1-11

    • DOI

      10.1080/24701394.2016.1238902

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influence of Activation Time on Hemodynamic Parameters: a Simulation Study2016

    • Author(s)
      Kosuke Taniguchi, Hiromasa Utaki, Daichi Yamamoto, Yukiko Himeno, Akira Amano
    • Journal Title

      Advanced Biomedical Engineering

      Volume: 5 Issue: 0 Pages: 94-104

    • DOI

      10.14326/abe.5.94

    • NAID

      130005159154

    • ISSN
      2187-5219
    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic diversity of the captive Asian tapir population in Thailand, based on mitochondrial control region sequence data and the comparison of its nucleotide structure with Brazilian tapir2016

    • Author(s)
      Yuttamol Muangkram, Akira Amano, Worawidh Wajjwalku, Tanu Pinyopummintr, Nikorn Thongtip, Nongnid Kaolim, Manakorn Sukmak, Sumate Kamolnorranath, Boripat Siriaroonrat, Wanlaya Tipkantha, Umaporn Maikaew, Warisara Thomas, Kanda Polsrila, Kwanreaun Dongsaard, Saowaphang Sanannu, Anuwat Wattananorrasate
    • Journal Title

      MITOCHONDRIAL DNA

      Volume: - Issue: 4 Pages: 1-5

    • DOI

      10.3109/24701394.2016.1149828

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Method for Determining Scale Parameters in a Hemodynamic model incorporating Cardiac Cellular Contraction model2016

    • Author(s)
      Hiromasa Utaki, Kosuke Taniguchi, Hiroya Konishi, Yukiko Himeno, Akira Amano
    • Journal Title

      Advanced Biomedical Engineering

      Volume: 5 Pages: 32-42

    • NAID

      130005139935

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanisms underlying the volume regulation of the interstitial fluid by capillaries: a simulation study2016

    • Author(s)
      Yukiko Himeno, Masayuki Ikebuchi, Akitoshi Maeda, Akinori Noma, Akira Amano
    • Journal Title

      Integrative Medicine Research

      Volume: 5(1) Issue: 1 Pages: 11-21

    • DOI

      10.1016/j.imr.2015.12.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A motion tracking method that applies a spread spectrum communication technique to tagging MR imaging.2015

    • Author(s)
      Komori Y, Amano A, Maehara K, Jin L, Narazaki M, Matsuda T.
    • Journal Title

      Magn Reson Med Sci

      Volume: 14(1) Pages: 25-34

    • NAID

      130004700393

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Application of the Kalman Filter for Faster Strong Coupling of Cardiovascular Simulations2015

    • Author(s)
      Yuki Hasegawa, Takao Shimayoshi, Akira Amano, Tetsuya Matsuda
    • Journal Title

      IEEE Journal of Biomedical and Health Informatics

      Volume: 99 Issue: 4 Pages: 0-0

    • DOI

      10.1109/jbhi.2015.2436212

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A human ventricular myocyte model with refined representation of excitation-contraction coupling2015

    • Author(s)
      Y. Himeno, K. Asakura, C. Y. Cha, H. Memida, T. Powell, A. Amano, A. Noma
    • Journal Title

      Biophys. J

      Volume: 109, 2 Issue: 2 Pages: 415-427

    • DOI

      10.1016/j.bpj.2015.06.017

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative Decomposition of Dynamics of Mathematical Cell Models: Method and Application to Ventricular Myocyte Models2015

    • Author(s)
      Takao Shimayoshi, Chae Young Cha, Akira Amano
    • Journal Title

      PLoS ONE

      Volume: 10(6) Issue: 6 Pages: e0124970-e0124970

    • DOI

      10.1371/journal.pone.0124970

    • NAID

      120005997770

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 心臓ペースメーカー細胞のイオン機序について2015

    • Author(s)
      姫野友紀子,天野晃,野間昭典
    • Journal Title

      循環器専門医

      Volume: 23/1 Pages: 9-17

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simulation System for Multiscale Biological Function Models that Require Complex Calculation Scheme2015

    • Author(s)
      天野 晃,プンザラン フローレンシオ ラスティ,嶋吉 隆夫,國枝 義敏
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 53 Issue: 3 Pages: 115-122

    • DOI

      10.11239/jsmbe.53.115

    • NAID

      130005106895

    • ISSN
      1347-443X, 1881-4379
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Program Code Generator for Cardiac Electrophysiology Simulation with Automatic PDE Boundary Condition Handling2015

    • Author(s)
      Florencio Rusty Punzalan, Yoshitoshi Kunieda, Akira Amano
    • Journal Title

      PLoS ONE

      Volume: 10(9) Issue: 9 Pages: e0136821-e0136821

    • DOI

      10.1371/journal.pone.0136821

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] EAD and DAD mechanisms analyzed by developing a new human ventricular cell model2014

    • Author(s)
      K. Asakura, C. Cha, H. Yamaoka, Y. Horikawa, H. Memida, T. Powell, A. Amano, A. Noma
    • Journal Title

      Progress in Biophysics and Molecular Biology

      Volume: 116(1) Issue: 1 Pages: 11-24

    • DOI

      10.1016/j.pbiomolbio.2014.08.008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 圧反射モデルを導入した循環動態モデル2014

    • Author(s)
      天野晃
    • Journal Title

      循環制御

      Volume: 35(2) Pages: 84-88

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 杆体・錐体視細胞光応答機構初期過程モデルによる視物質ートランスデューシン間シグナル増幅現象の再現2014

    • Author(s)
      細木ゆかり,小池千恵子,竹田有加里,天野晃
    • Journal Title

      生体医工学

      Volume: 52(3) Pages: 145-155

    • NAID

      130004691215

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 貫壁性不均一性が心エネルギー効率に与える影響に関する理論的解析2014

    • Author(s)
      長谷川雄基,三島充晴,嶋吉隆夫,天野晃,松田哲也
    • Journal Title

      生体医工学

      Volume: 52(3) Pages: 129-135

    • NAID

      130004691213

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ヒトiPS由来心筋細胞の数理モデルの構築と心室筋・心房筋・洞結節様細胞の解析2017

    • Author(s)
      糀谷 泰彦,幸田 茂也,姫野 友紀子,山本 菜月,牧山 武,張田 健志,木村 剛,野間 昭典, 天野 晃
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県・浜松市)
    • Year and Date
      2017-03-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] A new myofilament contraction model to calculate ATP consumption of the ventricular myocyte2017

    • Author(s)
      Yuttamol Muangkram, Akinori Noma, Akira Amano
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県・浜松市)
    • Year and Date
      2017-03-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒト心室筋細胞モデルを用いたヒト循環動態シミュレーションモデル2017

    • Author(s)
      卯滝 裕正,姫野 友紀子,野間 昭典,天野 晃
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県・浜松市)
    • Year and Date
      2017-03-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] 心筋細胞形態や組織構築構造と興奮伝播速度の関係性に関する理論的考察2017

    • Author(s)
      内藤 成美,津元 国親,倉智 嘉久,天野 晃
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県・浜松市)
    • Year and Date
      2017-03-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] A Photoreceptor Model Considering Regulation of Ionic HomeostasisとSimulation Analysis of Phototransduction System in Rods2017

    • Author(s)
      Kazuma Sato, Yukiko Himeno, Yukari Takeda, Akira Amano
    • Organizer
      Biophysical Society 61st Annual Meeting
    • Place of Presentation
      New Orleans (USA)
    • Year and Date
      2017-02-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Simulation Analysis of Phototransduction Systems in Rods and Cones2017

    • Author(s)
      Kazuma Sato, Saya Ito, Yukari Hosoki, Yukari Takeda, Chieko Koike, Amano Akira
    • Organizer
      Biophysical Society 61st Annual Meeting
    • Place of Presentation
      New Orleans (USA)
    • Year and Date
      2017-02-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Simulation of cardiac excitation propagation and the circulatory dynamics2016

    • Author(s)
      Akira AMANO, Hiromasa UTAKI, Kosuke TANIGUCHI and Yukiko HIMENO
    • Organizer
      NOLTA 2016
    • Place of Presentation
      ニューウェルシティ湯河原(静岡県・熱海市)
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] イオン濃度恒常性を考慮した杆体視細胞モデル2016

    • Author(s)
      伊藤さや,佐藤一誠,姫野友紀子,竹田有加里,天野晃
    • Organizer
      Life Engineering シンポジウム
    • Place of Presentation
      大阪国際交流センター(大阪府・大阪市)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 微小循環モデルにおける組織内間質液量およびタンパク質量の定常解計算法2016

    • Author(s)
      池淵昌幸,前田陽俊,姫野友紀子,野間昭典,天野晃
    • Organizer
      第109回近畿生理学談話会
    • Place of Presentation
      大阪市立大学(大阪府・大阪市)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒトiPS由来心筋細胞の数理モデルの開発2016

    • Author(s)
      幸田茂也,山本菜月,糀谷泰彦,姫野友紀子,野間昭典,天野晃
    • Organizer
      第109回近畿生理学談話会
    • Place of Presentation
      大阪市立大学(大阪府・大阪市)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒト心室筋細胞1次元細胞配列における興奮伝播と細胞外電位変化のイオン機序2016

    • Author(s)
      山本菜月,松本珠実,氏原美玲,野間昭典,天野晃
    • Organizer
      第109回近畿生理学談話会
    • Place of Presentation
      大阪市立大学(大阪府・大阪市)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 毛細血管体液交流数学モデルの組織コロイド浸透圧と静水圧2016

    • Author(s)
      前田陽俊,池淵昌幸,姫野友紀子,野間昭典,天野晃
    • Organizer
      第109回近畿生理学談話会
    • Place of Presentation
      大阪市立大学(大阪府・大阪市)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 数理モデルを基盤とした循環生理学教育のための電子教材開発 (e-Heart project)2016

    • Author(s)
      野間昭典, 姫野友紀子、天野晃
    • Organizer
      第109回近畿生理学談話会
    • Place of Presentation
      大阪市立大学(大阪府・大阪市)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 円板膜状態を考慮した桿体・錐体視細胞光電位変換機構モデル2016

    • Author(s)
      佐藤一誠,伊藤さや,細木ゆかり,竹田有加里,小池千恵子,天野晃
    • Organizer
      視覚科学フォーラム
    • Place of Presentation
      大阪大学(大阪府・吹田市)
    • Year and Date
      2016-08-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Semi-automatic mapping of variables between biological function model and numerical calculation scheme2016

    • Author(s)
      Taiki Tatara, Takeru Arita, Yoshitoshi Kunieda, Akira Amano
    • Organizer
      Cardiac Physiome Workshop
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2016-08-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Relation between Activation Time and Hemodynamics - Simulation Study with Hemodynamic Model Comprising Cardiac Tissue Model2016

    • Author(s)
      Kosuke Taniguchi, Hiromasa Utaki, Daichi Yamamoto, Yukiko Himeno, Akira Amano
    • Organizer
      Cardiac Physiome Workshop
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Mathematical Analysis of NA-induced Automaticity of the Rat Pulmonary Vein Cardiomyocyte2016

    • Author(s)
      Shohei Umehara, Yukiko Himeno, Kyoichi Ono, Akinori Noma, Akira Amano
    • Organizer
      Cardiac Physiome Workshop
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Ionic mechanismsunderlying ventricular fibrillation examined in an one-dimensional array of human ventricular myocyte model2016

    • Author(s)
      Mirei Ujihara, Natsuki Yamamoto, Akinori Noma, Akira Amano
    • Organizer
      Cardiac Physiome Workshop
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] The ionic mechanisms underlying the propagation of action potential and the extracellular potential changes analyzed in a one-dimensional cell array of human ventricular cell models2016

    • Author(s)
      Yamamoto Natsuki, Matsumoto Tamami, Ujihara Mirei, Noma Akinori, Amano Akira
    • Organizer
      Cardiac Physiome Workshop
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] A Huxley-based contraction model to reconstruct the accompanying ATP consumption in cardiac myocytes.2016

    • Author(s)
      Yuttamol Muangkram, Kosuke Taniguchi, Akinori Noma, Akira Amano
    • Organizer
      Cardiac Physiome Workshop
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] A Human Ventricular Excitation-Contraction Coupling Model2016

    • Author(s)
      Yukiko, Himeno, Trevor Powell, Akira Amano, Akinori Noma
    • Organizer
      Cardiac Physiome Workshop
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Touchscreen-based visual temporal discrimination task in the behaving mouse by the constant method2016

    • Author(s)
      Yuichiro Nomura, Jumpei Mita, Shingo Takizawa, Takuma Arimura, Shinichiro Suzuki, Shohei Ikuta, Akira Amano, Yasuhiro Tsubo, Kazuhiro Shimonomura, Yasuhiro Seya, Chieko Koike
    • Organizer
      ARVO 2016
    • Place of Presentation
      Seattle (USA)
    • Year and Date
      2016-05-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] 循環系の統合的理解のための細胞・組織・臓器レベル生理学知見集約生体機能モデル2016

    • Author(s)
      天野晃
    • Organizer
      第55回生体医工学会大会
    • Place of Presentation
      富山国際会議場(富山県・富山市)
    • Year and Date
      2016-04-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Naチャネル発現変化からの催不整脈性トリガー予測:ブルガダ症候群との関連において2016

    • Author(s)
      津元国親,芦原貴司,内藤成美,天野晃,中沢一雄,倉智嘉久
    • Organizer
      第55回生体医工学会大会
    • Place of Presentation
      富山国際会議場(富山県・富山市)
    • Year and Date
      2016-04-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 微小な毛細血管血圧変化が組織液量と組織内タンパク質量に及ぼす影響の解析:シミュレーションによる解析2016

    • Author(s)
      池淵昌幸,姫野友紀子,野間昭典,天野晃
    • Organizer
      第55回生体医工学会大会
    • Place of Presentation
      富山国際会議場(富山県・富山市)
    • Year and Date
      2016-04-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] オペラントシステムを用いた恒常法によるマウス限界フリッカー値の同定/The resolution of mouse flicker fusion threshold by constant method in the behaving mouse.2016

    • Author(s)
      野村 悠一郎, 三田 純平, 有村 琢磨, 生田 昌平, 瀧澤 伸剛, 鈴木慎一郎、坪泰宏、天野 晃, 下ノ村 和弘、瀬谷 安弘、小池 千恵子
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] A Teaching Material for Cardiac Physiology - systematic compilation of biophysical simulation models of cardiac cellular function (e-Heart project)2016

    • Author(s)
      Noma Akinori, Himeno Yukiko, Trevor Powell, Amano Akira
    • Organizer
      日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of a couplon model based on data from experimental and simulated Ca2+ sparks2016

    • Author(s)
      Himeno Yukiko, Trevor Powell, Amano Akira, Noma Akinori
    • Organizer
      日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Research-status Report
  • [Presentation] A Mathematical Modeling of Phase-2 Reentry Attributable to Changes in Subcellular Expression of Nav1.5 Channel2016

    • Author(s)
      Tsumoto Kunichika, Ashihara Takashi, Naito Narumi, Amano Akira, Nakazawa Kazuo, Kurachi Yoshihisa
    • Organizer
      日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Research-status Report
  • [Presentation] ATP consumption by the cardiac muscle contraction implemented in a Huxley-based contraction model2016

    • Author(s)
      Muangkram Yuttamol, Taniguchi Kosuke, Noma Akinori, Amano Akira
    • Organizer
      日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Developmento of a microcirculation model to calculate glucose supply to meet the cellular requirement2016

    • Author(s)
      Maeda Akitoshi, Himeno Yukiko, Noma Akinori, Amano Akira
    • Organizer
      日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] NA-induced Automaticity of the Rat Pulmonary Vein Cardiomyocyte demonstrated in a Matehmatical Model2016

    • Author(s)
      Umehara Shohei, Himeno Yukiko, Ono Kyoichi, Noma Akinori, Amano Akira
    • Organizer
      日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Measurement of cardiac action potential in anesthetized guinea pig for estimating drug action on ion channel conductance2016

    • Author(s)
      Maekawa Saki, Watanabe Risa, Himeno Yukiko, Noma Akinori, Amano Akira
    • Organizer
      日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Ionic mechanisms underlying ventricular fibrillation examined in a one-dimensional array of human ventricular myocyte model2016

    • Author(s)
      Ujihara Mirei, Yamamoto Natsuki, Noma Akinori, Amano Akira
    • Organizer
      日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] The ionic mechanism of electrocardiogram examined using a one-dimensional array of human ventricular cell model2016

    • Author(s)
      Yamamoto Natsuki, Ujihara Mirei, Noma Akinori, Amano Akira
    • Organizer
      日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 非線形方程式求根アルゴリズムの宣言的形式言語の設計2016

    • Author(s)
      嶋吉 隆夫, 天野 晃
    • Organizer
      情報処理学会プログラミング研究会
    • Place of Presentation
      ARKビル(福岡県福岡市)
    • Year and Date
      2016-01-13
    • Related Report
      2015 Research-status Report
  • [Presentation] 3次元位置合わせ機構を実装した光ピンセットの開発2015

    • Author(s)
      野原有実,天野晃,杉浦忠男
    • Organizer
      電気関係学会関西支部大会
    • Place of Presentation
      摂南大学( 大阪府寝屋川市)
    • Year and Date
      2015-11-14
    • Related Report
      2015 Research-status Report
  • [Presentation] 詳細な心筋細胞モデルから構築する心臓モデル2015

    • Author(s)
      天野晃
    • Organizer
      生理学研究所 研究会「心臓・血管系の包括的な機能統合研究」
    • Place of Presentation
      生理学研究所(愛知県岡崎市)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒト心室筋細胞モデル一次元配列を用いたJ波の成因メカニズム解析2015

    • Author(s)
      山本菜月, 氏原美玲, 野間昭典, 天野晃
    • Organizer
      近畿生理談話会
    • Place of Presentation
      近畿大学(大阪府東大阪市)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒト心室筋細胞モデルの一次元配列による心室細動の再現とイオン機序2015

    • Author(s)
      氏原美玲, 山本菜月, 野間昭典, 天野晃
    • Organizer
      近畿生理談話会
    • Place of Presentation
      近畿大学(大阪府東大阪市)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 毛細血管における体液交流とグルコース供給モデルの構築2015

    • Author(s)
      前田陽俊, 姫野友紀子, 野間昭典, 天野晃
    • Organizer
      近畿生理談話会
    • Place of Presentation
      近畿大学(大阪府東大阪市)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
  • [Presentation] CaRUを導入したラット肺静脈心筋細胞モデルにおけるノルアドレナリン誘発自動能の再現2015

    • Author(s)
      梅原象平,姫野友紀子,尾野恭一,野間昭典,天野晃
    • Organizer
      近畿生理談話会
    • Place of Presentation
      近畿大学(大阪府東大阪市)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
  • [Presentation] The evaluation of visual temporal resolution in the behaving mouse2015

    • Author(s)
      J. Mita, S. Yokota, S. Ikuta, S. Takizawa, Y. Nomura, T. Arimura, A. Amano, K. Shimonomura, Y. Seya, Y. Tsubo, C. Koike
    • Organizer
      SFN annual meeting 2015
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] モデル変数と数値計算スキームとの半自動対応付け機能を持つ生体機能シミュレーションツール: CellCompiler2015

    • Author(s)
      有田健, 多々良泰基, 小見山繁, 鈴木洋平, 國枝義敏, 天野晃
    • Organizer
      生体医工学シンポジウム
    • Place of Presentation
      岡山国際交流センター(岡山県岡山市)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
  • [Presentation] The Influence of Activation Time on the Hemodynamic Parameters: a Simulation Study2015

    • Author(s)
      Kosuke Taniguchi, Hiromasa Utaki, Daichi Yamamoto, Akira Amano
    • Organizer
      生体医工学シンポジウム
    • Place of Presentation
      岡山国際交流センター(岡山県岡山市)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Analysis of Glycolytic ATP Production Rate and the Rate Limiting Step under ischemic ATP/NAD concentration2015

    • Author(s)
      Manami Fuchigami, Akira Amano
    • Organizer
      生体医工学シンポジウム
    • Place of Presentation
      岡山国際交流センター(岡山県岡山市)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Analysis of Relation between Cardiac Cellular Characteristics and Hemodynamics Parameters using Hemodynamics Model incorporating2015

    • Author(s)
      Hiromasa Utaki, Kosuke Taniguchi, Hiroya Konishi, Akira Amano
    • Organizer
      生体医工学シンポジウム
    • Place of Presentation
      岡山国際交流センター(岡山県岡山市)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 生体機能シミュレーションにおけるPCクラスタ環境での計算結果収集手法2015

    • Author(s)
      中川貴裕,桑原寛明,國枝義敏,天野晃
    • Organizer
      生体医工学シンポジウム
    • Place of Presentation
      岡山国際交流センター(岡山県岡山市)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Required ATP/NAD concentration for the constant ATP production by glycolysis2015

    • Author(s)
      Manami Fuchigami, Akira Amano
    • Organizer
      日本生理学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-03-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Mathematical model of Ca2+ induced Ca2+ release in ventricular myocyte2015

    • Author(s)
      Yukiko Himeno, Keiichi Asakura, Cha Chae Young, Hiraku Memida, Trevor Powell, Akira Amano, Akinori Noma
    • Organizer
      日本生理学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-03-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Relation between the Hemodynamic Macroscopic and the Microscopic Parameters; Model Study2015

    • Author(s)
      Hiromasa Utaki, Hiroya Konishi, Kosuke Taniguchi,k Akira Amano
    • Organizer
      日本生理学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-03-21
    • Related Report
      2014 Research-status Report
  • [Presentation] A ventricular cell model refined on Ca2+-induced Ca2+-release2015

    • Author(s)
      Hiraku Memida, Yukiko Himeno, Keiichi Asakura, Akira Amano, Akinori Noma
    • Organizer
      日本生理学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-03-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Nonlinear Multiscale Circulation Model Reproducable Linear End-Systolic Pressure-Volume Relationship2014

    • Author(s)
      Takao Shimayoshi, Mitsuharu MISHIMA, Akira Amano, Tetsuya Matsuda
    • Organizer
      IEEE EMB Conference
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-08-30
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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