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Development of measurement and evaluation system of erythrocyte deformability embedded into a conventional blood test system

Research Project

Project/Area Number 26350521
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionKansai University

Principal Investigator

Tajikawa Tsutomu  関西大学, システム理工学部, 准教授 (80351500)

Co-Investigator(Kenkyū-buntansha) 田窪 孝行  大阪医科大学, 医学部, 名誉教授 (60163359)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords赤血球変形能 / 粘弾性モデル / 形状回復時定数 / マイクロ流体システム / シースフロー型マイクロチャンネル / 糖尿病 / 膠原病 / 懸濁液粘度 / 血液分析チップ / シースフロー / 血液分離チップ
Outline of Final Research Achievements

In this study, the relaxation time constant of shape recovery process of each red blood cell from various peripheral circulatory failure was measured by based on the standard linear solid visco-elastic mode to evaluate red blood cell deformability by using micro-channel technique.
As the result, time constant of diabetic renal disease could detect only stage G5 as same as a person requiring dialysis, but there was not differences in the case of transitional phase of nephropathy progression. The time constant of the blood from collagen disease was shorter than healthy samples and its deviation in collagen disease sample was mach wider.
And the Sheath flow type micro-channel chip had been successfully developed and fabricated. This newly micro-channel had realized not only high throughput and high resolution testing for erythrocyte deformabiity but also possibility of measuring suspension viscosity with single erythrocyte in a micro channel.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (11 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Measurement of Erythrocyte Deformability by Uniaxial Stretching2015

    • Author(s)
      郡慎平,加藤陽介,田地川勉,山本恭史,板東潔
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 53 Issue: 1 Pages: 1-7

    • DOI

      10.11239/jsmbe.53.1

    • NAID

      130005084160

    • ISSN
      1347-443X, 1881-4379
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 単軸引張によるヒト赤血球の変形能の測定―見かけのヤング率と形状回復時定数の測定―2015

    • Author(s)
      郡慎平,加藤陽介,田地川勉,山本恭史,板東潔
    • Journal Title

      生体医工学

      Volume: 53(1) Pages: 1-7

    • NAID

      130005084160

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 可視化による赤血球変形能の定量評価: 形状回復時定数を使った個々の血球の粘弾性特性の測定2014

    • Author(s)
      田地川勉
    • Journal Title

      可視化情報学会誌

      Volume: 34(134) Pages: 114-119

    • NAID

      130005435183

    • Related Report
      2014 Research-status Report
    • Open Access / Acknowledgement Compliant
  • [Presentation] マイクロチャンネル法によるヒト赤血球変形能の定量評価(シースフロー型マイクロチャンネルによる高効率化)2017

    • Author(s)
      入野啓司,山下雄士,田地川勉,大友涼子,山本恭史,板東潔
    • Organizer
      日本機械学会関西支部 平成28年度関西学生会学生員卒業研究発表講演会
    • Place of Presentation
      大阪府・大阪大学工学部
    • Year and Date
      2017-03-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] マイクロチャンネル法によるヒト赤血球変形能の定量評価(膠原病と形状回復時定数の関係)2017

    • Author(s)
      山下雄士, 田地川勉, 池本敏行, 武内徹
    • Organizer
      日本機械学会 第29回バイオエンジニアリング講演会
    • Place of Presentation
      愛知県・ウインクあいち
    • Year and Date
      2017-01-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] In vitro Hemodynamical Performance Evaluation of Endovascular Devices for Treating Intracranial Aneurysm: Comparison of our developed NCVC Microporous Covered Stent vs Flow Diverter stents2016

    • Author(s)
      T. Tajikawa, T. Moriwaki, Y. Nakayama
    • Organizer
      13th International IntraCranial Stent Meeting
    • Place of Presentation
      Hyogo Pref.・Kobe International Exhibition Hall
    • Year and Date
      2016-11-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 過凝集性牛乳を使った血流停滞による血栓形成模擬実験系構築の試み2016

    • Author(s)
      田地川勉,田中雅之,矢野良輔,柳楽恭子
    • Organizer
      第64 回レオロジー討論会
    • Place of Presentation
      大阪府・大阪大学基礎工学部
    • Year and Date
      2016-10-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] マイクロチャンネル法による赤血球変形能の評価(膠原病患者に対する形状回復時定数の測定)2016

    • Author(s)
      田地川勉,山下雄士,池本敏行,武内徹
    • Organizer
      第39回日本バイオレオロジー学会年会
    • Place of Presentation
      東京都・東海大学校友会館
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 1単軸引張試験によるヒト赤血球の変形能の測定(硬化赤血球の見かけのヤング率と形状回復時定数の関係)2015

    • Author(s)
      永井勇大,郡慎平,田地川勉,板東潔
    • Organizer
      第38回日本バイオレオロジー学会年会
    • Place of Presentation
      学術総合センター(東京都)
    • Year and Date
      2015-06-06
    • Related Report
      2015 Research-status Report
  • [Presentation] 光ピンセットを用いた赤血球の粘弾性特性の測定2015

    • Author(s)
      増田豊行, 田地川勉
    • Organizer
      日本機械学会関西支部 第90期定時総会講演会
    • Place of Presentation
      京都大学 桂キャンパス
    • Year and Date
      2015-03-16 – 2015-03-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 単軸引張試験によるヒト赤血球の見かけのヤング率の測定―膜硬化の影響―2015

    • Author(s)
      永井勇大, 郡慎平, 田地川勉, 板東潔, 山本恭史, 大友涼子, 加藤陽介
    • Organizer
      日本機械学会 第27回バイオエンジニアリング講演会
    • Place of Presentation
      朱鷺メッセ(新潟県)
    • Year and Date
      2015-01-09 – 2015-01-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 単軸引張によるヒト赤血球の変形能の測定―見かけのヤング率と形状回復時定数の関係―2014

    • Author(s)
      郡慎平, 加藤陽介, 田地川勉, 山本恭史, 板東潔
    • Organizer
      生体医工学シンポジウム2014
    • Place of Presentation
      東京農工大学 小金井キャンパス
    • Year and Date
      2014-09-26 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Measurement of erythrocyte deformability as a visco-elastic properties by micro-channel technique (Influence of MCV, MCHC and glycation on relaxation time)2014

    • Author(s)
      Tsutomu Tajikawa, Maki Kubota, Takuya Nota, Toshiyuki Ikemoto, Takayuki Takubo
    • Organizer
      7th World Congress of Biomechanics
    • Place of Presentation
      Boston, USA
    • Year and Date
      2014-07-06 – 2014-07-11
    • Related Report
      2014 Research-status Report
  • [Presentation] マイクロチャンネル法によるヒト赤血球変形能の評価(糖尿病患者における血液検査値と形状回復時定数の関係)2014

    • Author(s)
      能田卓弥, 田地川勉, 池本敏行, 田窪孝行
    • Organizer
      第37回日本バイオレオロジー学会年会
    • Place of Presentation
      大宮ソニックシティビル 市民ホール(埼玉県)
    • Year and Date
      2014-06-06 – 2014-06-07
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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