Development of measurement and evaluation system of erythrocyte deformability embedded into a conventional blood test system
| Project/Area Number |
26350521
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kansai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
田窪 孝行 大阪医科大学, 医学部, 名誉教授 (60163359)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 赤血球変形能 / 粘弾性モデル / 形状回復時定数 / マイクロ流体システム / シースフロー型マイクロチャンネル / 糖尿病 / 膠原病 / 懸濁液粘度 / 血液分析チップ / シースフロー / 血液分離チップ |
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| Outline of Final Research Achievements |
In this study, the relaxation time constant of shape recovery process of each red blood cell from various peripheral circulatory failure was measured by based on the standard linear solid visco-elastic mode to evaluate red blood cell deformability by using micro-channel technique.
As the result, time constant of diabetic renal disease could detect only stage G5 as same as a person requiring dialysis, but there was not differences in the case of transitional phase of nephropathy progression. The time constant of the blood from collagen disease was shorter than healthy samples and its deviation in collagen disease sample was mach wider.
And the Sheath flow type micro-channel chip had been successfully developed and fabricated. This newly micro-channel had realized not only high throughput and high resolution testing for erythrocyte deformabiity but also possibility of measuring suspension viscosity with single erythrocyte in a micro channel.
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Report
(4 results)
Research Products
(14 results)
