Development of effective BNCT drug by using supramolecular complexation
| Project/Area Number |
26350528
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Masunaga Shin-ichiro 京都大学, 原子炉実験所, 教授 (80238914)
MAzuma Hideki 大阪市立大学, 大学院工学研究科, 講師 (80311918)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 薬物送達システム / ホウ素中性子捕捉療法 / がん治療 / 超分子化学 / 包接化合物 / ターゲティング / ナノメディシン / シクロデキストリン / 超分子 / がん転移 / 水溶化剤 / 転移抑制 / 抗がん剤 / 生体材料 / ナノ材料 / 癌 / ナノバイオ |
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| Outline of Final Research Achievements |
A novel water-soluble complex between boron cluster carborane-kojic acid conjugate(CKA) and hydroxylpropyl-beta-cyclodextrin (HP-betaCD) hve been prepared. It was revealed that CKA-HP-betaCD complex inhibited the metastasis of melanoma cells in vivo. It was suggested that the inhibitory ability of CKA to HIF-1alpha contributed to suppress the matastasis. Furthermore, in this study, the quantitative evaluation of the CKA’s inhibitory ability was carried out by quantitative real-time PCR in vivo. From the results of real-time PCR, CKA remarkably suppressed melanoma metastasis to the brain among other organs.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Water-Solubilization of Fullerene Derivatives by β-(1,3-1,6)-DGlucan and Their Photodynamic Activities toward Macrophages2017
Author(s)
Atsushi Ikeda, Tatsuya Iizuka, Naotake Maekubo, Kazuyuki Nobusada, Kota Sugisawa, Kazuya Komoto, Toshio Suzuki, Takeshi Nagasaki, Motofusa Akiyama
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Journal Title
Chemistry-An Asian Journal
Volume: 12
Issue: 10
Pages: 1069-1074
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] コウジ酸修飾カルボランのメラノーマＢＮＣＴ薬剤としての評価2014
Author(s)
長﨑 健，河崎 陸，増永慎一郎, 櫻井良憲,田中浩基，切畑光統
Organizer
平成26年度京都大学原子炉実験所専門研究会研究炉及び加速器中性子源を用いた中性子捕捉療法の高度化に関する研究会
Place of Presentation
大阪府熊取町京大原子炉実験所
Year and Date
2014-09-29 – 2014-09-30
Related Report
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