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Formation of functional 3D tissues suitable for transplantation by liver and pancreatic cells

Research Project

Project/Area Number 26350530
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionChiba University (2016-2018)
Tokyo Women's Medical University (2014-2015)

Principal Investigator

Utoh Rie  千葉大学, 大学院工学研究院, 日本学術振興会特別研究員(RPD) (70593169)

Research Collaborator YAMADA Masumi  千葉大学, 大学院工学研究院, 准教授
SEKI Minoru  千葉大学, 大学院工学研究院, 教授
YAMATO Masayuki  東京女子医科大学, 先端生命医科学研究所, 教授
Project Period (FY) 2015-03-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肝細胞 / 膵島細胞 / 組織工学 / コラーゲン / 細胞外マトリックス / 移植 / 膵島組織 / 肝組織 / 膵島 / ハイドロゲル / 細胞治療
Outline of Final Research Achievements

We have developed new strategies for production of high functional three-dimensional (3D) tissues using hepatocytes and islet cells that can be efficiently engrafted and function in vivo. First, size-controlled islet-like tissues were prepared from dispersed rat islet cells using precisely-fabricated agarose gel-based microwells. As a result of the culture of islet-like tissues for 7 days, dead cells were rarely present in the small islet-like tissues and the islet cells restored the high insulin secretory capacity in response to high glucose. These results clearly suggest that precise size control of islet-like cells is essential for maintaining islet cell function and survival. In addition, we produced microscale scaffolds with spherical or linear structure from type I collagen and Matrigel for reconstitution of high-functional 3D tissues and evaluated the effects of the microscale scaffolds on survival and functions of hepatocytes.

Academic Significance and Societal Importance of the Research Achievements

肝疾患や1型糖尿病治療のために,肝細胞移植,膵島移植などの細胞移植療法が試みられているが,現状では,顕著な治療効果が得られない,または長期成績が不良であるなど克服すべき課題が多い。本研究では,細胞移植による治療効果の改善を目指し,肝細胞や膵島細胞を用いて,生体内での長期生着・機能維持に有利な,機能性3次元組織体の作製を行った。移植効率が改善できることによって,移植する細胞数を減らすこともでき,ドナー不足の改善にも期待できる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (75 results)

All 2019 2018 2017 2016 2015 Other

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (65 results) (of which Int'l Joint Research: 18 results) Remarks (2 results)

  • [Journal Article] PDMS Microstencil Plate-supported Fabrication of Ultra-thin, Condensed ECM Membranes for Separated Cell Coculture on Both Surfaces2019

    • Author(s)
      Hideki Iwadate, Masumi Yamada, Naoki Kimura, Rina Hashimoto, Yuya Yajima, Rie Utoh, and Minoru Seki
    • Journal Title

      Sensors and Actuators B: Chemical

      Volume: 287 Pages: 486-495

    • DOI

      10.1016/j.snb.2019.02.067

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adult hepatocytes direct liver organogenesis through non-parenchymal cell recruitment in the kidney.2018

    • Author(s)
      Utoh R, Komori J, Kuge H, Tatsumi K, Yamada M, Hirohashi S, Tsutsumi M, Amanuma T, Yoshioka A, Nakajima Y, Wake K, Okano T, Lagasse E, Ohashi K.
    • Journal Title

      J Hepatol.

      Volume: 68 Issue: 4 Pages: 744-753

    • DOI

      10.1016/j.jhep.2017.12.016

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The liver surface as a favorable site for islet cell sheet transplantation in type 1 diabetes model mice2018

    • Author(s)
      Fujita Izumi、Utoh Rie、Yamamoto Masakazu、Okano Teruo、Yamato Masayuki
    • Journal Title

      Regenerative Therapy

      Volume: 8 Pages: 65-72

    • DOI

      10.1016/j.reth.2018.04.002

    • NAID

      120006576195

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a Perfusable 3D Liver Cell Cultivation System via Bundling-up Assembly of Cell-laden Microfibers2018

    • Author(s)
      Yuya Yajima, Chu Ning Lee, Masumi Yamada, Rie Utoh, and Minoru Seki
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: in press Issue: 1 Pages: 111-118

    • DOI

      10.1016/j.jbiosc.2018.01.022

    • NAID

      210000005735

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Micropassage-embedding Composite Hydrogel Fibers Enable Quantitative Evaluation of Cancer Cell Invasion under 3D Coculture Conditions2018

    • Author(s)
      Sugimoto M, Kitagawa Y, Yamada M, Yajima Y, Utoh R, Seki M
    • Journal Title

      Lab Chip

      Volume: 印刷中 Issue: 9 Pages: 1378-1387

    • DOI

      10.1039/c7lc01280b

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Collagen Microparticle-Mediated 3D Cell Organization: A Facile Route to Bottom-up Engineering of Thick and Porous Tissues2017

    • Author(s)
      Yajima Y, Yamada M, Utoh R, and Seki M
    • Journal Title

      ACS Biomater Sci Eng

      Volume: 3(9) Issue: 9 Pages: 2144-2154

    • DOI

      10.1021/acsbiomaterials.7b00131

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Size effect of engineered islets prepared using microfabricated wells on islet cell function and arrangement.2016

    • Author(s)
      Ichihara Y, Utoh R, Yamada M, Shimizu T, Uchigata Y.
    • Journal Title

      Heliyon

      Volume: 2(6) Issue: 6 Pages: e00129-e00129

    • DOI

      10.1016/j.heliyon.2016.e00129

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cell-sized condensed collagen microparticles for preparing microengineered composite spheroids of primary hepatocytes2015

    • Author(s)
      Masumi Yamada, Ayaka Hori, Sari Sugaya, Yuya Yajima, Rie Utoh, Masayuki Yamato, and Minoru Seki
    • Journal Title

      Lab on a Chip

      Volume: 15 (19) Issue: 19 Pages: 3941-3951

    • DOI

      10.1039/c5lc00785b

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 断片化マイクロコラーゲンファイバーを導入した肝細胞スフェロイド培養の肝機能への効果2019

    • Author(s)
      鵜頭理恵,榎本紗希子,山中啓吾,山田真澄,関 実
    • Organizer
      化学工学会 第84年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Microfabrication of Ultra-thin ECM Films for Controlled Cell Coculture Systems2019

    • Author(s)
      Hideki Iwadate, Masumi Yamada, Rie Utoh, Minoru Seki
    • Organizer
      化学工学会 第84年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肝スフェロイド培養における断片化コラーゲンマイクロファイバー内包の効果2019

    • Author(s)
      鵜頭理恵,榎本紗希子,山中啓吾,山田真澄,関 実
    • Organizer
      シンポジウム:細胞アッセイ技術の現状と将来
    • Related Report
      2018 Annual Research Report
  • [Presentation] マイクロステンシルプレート内濃縮によるECM薄膜の作製と肝臓細胞培養への応用2019

    • Author(s)
      岩舘秀樹,木村尚貴,橋本里奈,矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      シンポジウム:細胞アッセイ技術の現状と将来
    • Related Report
      2018 Annual Research Report
  • [Presentation] 膜乳化法によるコラーゲン微粒子の高効率調製と3次元細胞培養2018

    • Author(s)
      森田明寛,矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      第24回流動化・粒子プロセッシングシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 3次元微粒子培養系によるシート状肝組織のワンステップ作製2018

    • Author(s)
      森田明寛,矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      化学とマイクロ・ナノシステム学会 第38回研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] コラーゲン微粒子を用いたラット初代肝細胞の3次元積層培養2018

    • Author(s)
      森田明寛,矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      化学工学会 第50回秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細胞を内腔に導入可能なコラーゲンチューブのワンステップ作製2018

    • Author(s)
      佐伯琴音, 榎本紗希子, 矢嶋祐也, 鵜頭理恵, 山田真澄, 関 実
    • Organizer
      化学工学会 第50回秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 共連続水性2相系を利用する多孔性ハイドロゲルの作製と3次元細胞培養2018

    • Author(s)
      堀 有音,渡部有紀,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学工学会室蘭大会 2018(3支部合同大会)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 両面におけるHepG2細胞の共培養を可能とするECM薄膜の微細加工2018

    • Author(s)
      岩舘秀樹,木村尚貴,橋本里奈,矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      第25回 肝細胞研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マイクロ流体デバイスを用いた細胞の配列化およびカプセル化技術の開発2018

    • Author(s)
      佐伯琴音,榎本紗希子,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      2018年度 生物工学若手研究者の集い(若手会)夏のセミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] ECM薄膜を組み込んだ細胞培養用マイクロ灌流デバイスの開発2018

    • Author(s)
      岩舘秀樹,木村尚貴,橋本里奈,矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      2018年度 生物工学若手研究者の集い(若手会)夏のセミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] 多層マイクロ流体デバイスを用いた細胞導入コラーゲンチューブの作製2018

    • Author(s)
      佐伯琴音,榎本紗希子,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学とマイクロ・ナノシステム学会第37回研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 共連続水性2相分散系を用いた細胞培養用多孔性ハイドロゲルの作製2018

    • Author(s)
      堀 有音,渡部有紀,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学とマイクロ・ナノシステム学会第37回研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ECM薄膜を統合した細胞培養用マイクロ流体デバイス2018

    • Author(s)
      岩舘秀樹,木村尚貴,橋本里奈,矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      第25回 HAB研究機構学術年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Three Dimensional Organization Culture of Rat Hepatocytes Supported by Condensed Collagen Microparticles2018

    • Author(s)
      Akihiro Morita, Rie Utoh, Masumi Yamada, Yuya Yajima, Minoru Seki
    • Organizer
      The 14th Asian Congress on Biotechnology (ACB2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation of Cell-encapsulating Hydrogel Sponges Using Bicontinuous Dispersion of Aqueous Polymer Solutions2018

    • Author(s)
      Aruto Hori, Yuki Watabe, Yuya Yajima, Rie Utoh, Masumi Yamada, and Minoru Seki
    • Organizer
      1st G'L'owing Polymer Symposium in KANTO (GPS-K 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Separated Co-culture of Heterotypic Cells Using Microfabricated Thin ECM Membranes2018

    • Author(s)
      Hideki Iwadate, Naoki Kimura, Rina Hashimoto, Yuya Yajima, Rie Utoh, Masumi Yamada, and Minoru Seki
    • Organizer
      29th 2018 International Symposium on Micro-NanoMechatronics and Human Science (MHS 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation of Microvasculature-embedding Porous Hydrogels for 3D Cell Culture2018

    • Author(s)
      Aruto Hori, Yuki Watabe, Yuya Yajima, Rie Utoh, Masumi Yamada, and Minoru Seki
    • Organizer
      29th 2018 International Symposium on Micro-NanoMechatronics and Human Science (MHS 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Facile Preparation of Cell-Embedding Hydrogel Sponges for 3D cell culture2018

    • Author(s)
      Aruto Hori, Masumi Yamada, Yuki Watabe, Yuya Yajima, Rie Utoh, and Minoru Seki
    • Organizer
      24th Symposium of Young Asian Biological Engineer’s Community (YABEC 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Wrapping of Linear Cell Assemblies with Tubular Collagen Membranes Using Multilayered Microfluidic Devices2018

    • Author(s)
      Kotone Saeki, Masumi Yamada, Sakiko Enomoto, Yuya Yajima, Rie Utoh, and Minoru Seki
    • Organizer
      The 22st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fabrication of Microchannel Network‐Embedding Hydrogel Sponges for 3D Perfusion Culture of Mammalian Cells2018

    • Author(s)
      Aruto Hori, Yuki Watabe, Yuya Yajima, Rie Utoh, Masumi Yamada, and Minoru Seki
    • Organizer
      The 22st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fabrication of Cell-embedding Porous Hydrogel for Perfusion Culture of Mammalian Cells2018

    • Author(s)
      Aruto Hori, Yuki Watabe, Yuya Yajima, Rie Utoh, Masumi Yamada, and Minoru Seki
    • Organizer
      The 10th International Symposium on Microchemistry and Microsystems (ISMM 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高チロシン血症1型モデルマウスの腎被膜下における肝非実質細胞の動員を伴う肝臓創生2018

    • Author(s)
      鵜頭 理恵、小森 淳二、Eric Lagasse、大橋 一夫
    • Organizer
      第17回日本再生医療学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 流路内コラーゲンゲル堆積法によるチューブ状生体組織の作製2018

    • Author(s)
      福士万由,矢嶋祐也,古澤和也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学工学会 第83年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 共連続水性2相分散系を利用した細胞包埋スポンジ状ハイドロゲルの作製2018

    • Author(s)
      堀 有音 ,渡部有紀,矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      化学工学会 第83年会
    • Related Report
      2017 Research-status Report
  • [Presentation] ECMメンブレンを組み込んだマイクロ流体かん流培養システムの開発2018

    • Author(s)
      岩舘秀樹,木村尚貴,橋本里奈,矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      シンポジウム:細胞アッセイ技術の現状と将来
    • Related Report
      2017 Research-status Report
  • [Presentation] マトリックス内に生細胞を包埋可能なポンジ状ハイドロゲル培養系の開発2018

    • Author(s)
      堀 有音,渡部有紀,矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      シンポジウム:細胞アッセイ技術の現状と将来
    • Related Report
      2017 Research-status Report
  • [Presentation] 微粒子状足場材料を用いる3次元細胞培養法の開発と評価2017

    • Author(s)
      矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学工学会 第82年会
    • Place of Presentation
      芝浦工業大学 豊洲キャンパス
    • Year and Date
      2017-03-06
    • Related Report
      2016 Research-status Report
  • [Presentation] マイクロ流体デバイスを用いた「断片化」コラーゲンマイクロファイバーの作製とその応用2017

    • Author(s)
      榎本紗希子,矢嶋祐也,鵜頭理恵,山田真澄,古澤和也,関 実
    • Organizer
      化学工学会 第82年会
    • Place of Presentation
      芝浦工業大学 豊洲キャンパス
    • Year and Date
      2017-03-06
    • Related Report
      2016 Research-status Report
  • [Presentation] アルギン酸を犠牲層として用いるタンパク質マイクロファイバーの作製2017

    • Author(s)
      平松久卓,堀綾香,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学工学会 第82年会
    • Place of Presentation
      芝浦工業大学 豊洲キャンパス
    • Year and Date
      2017-03-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 微細加工ハイドロゲルシートを利用したがん浸潤評価系の開発2017

    • Author(s)
      杉本愛実,北川陽一,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      シンポジウム:細胞アッセイ技術の現状と将来
    • Place of Presentation
      東京大学 生産技術研究所
    • Year and Date
      2017-01-31
    • Related Report
      2016 Research-status Report
  • [Presentation] コラーゲン微粒子を足場として利用する3次元生体組織の作製と機能評価2017

    • Author(s)
      矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      シンポジウム:細胞アッセイ技術の現状と将来
    • Place of Presentation
      東京大学 生産技術研究所
    • Year and Date
      2017-01-31
    • Related Report
      2016 Research-status Report
  • [Presentation] 長さを制御可能な断片化コラーゲンマイクロファイバーの作製とその応用2017

    • Author(s)
      榎本紗希子,矢嶋祐也,山田真澄,鵜頭理恵,古澤和也,関 実
    • Organizer
      化学とマイクロ・ナノシステム学会第36回研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] タンパク質マイクロ粒子を用いた階層的細胞アセンブリシステム2017

    • Author(s)
      亀田真央,堀綾香,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      電気学会 バイオ・マイクロシステム研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] ECMマイクロ粒子を用いた膵島模倣組織の作製2017

    • Author(s)
      亀田真央,堀綾香,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学工学会 第49回秋季大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 基底膜の厚みを再現したECM薄膜の作製と細胞共培養への応用2017

    • Author(s)
      岩舘秀樹,木村尚貴,橋本里奈,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学工学会 第49回秋季大会 名古屋大学 東山キャンパス
    • Related Report
      2017 Research-status Report
  • [Presentation] ECM微粒子を内包した複合型膵島様組織の作製2017

    • Author(s)
      亀田真央,堀綾香,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      第69回日本生物工学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 微粒子状ECMスキャホールドを用いる肝細胞の3次元培養と機能評価2017

    • Author(s)
      矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      第69回日本生物工学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] マイクロ流体ウェットスピニングによるタンパク質ファイバーの作製2017

    • Author(s)
      平松久卓,堀綾香,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学工学会東京大会
    • Related Report
      2017 Research-status Report
  • [Presentation] コラーゲンチューブの流路内形成による血管様組織の作製2017

    • Author(s)
      福士万由,矢嶋祐也,古澤和也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学工学会東京大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 基底膜の厚みを再現する-マイクロステンシルプレートを利用したコラーゲン超薄膜の作製2017

    • Author(s)
      岩舘秀樹,木村尚貴,橋本里奈,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      生物工学若手研究者の集い 夏のセミナー2017
    • Related Report
      2017 Research-status Report
  • [Presentation] 流路内堆積法によるコラーゲンベース血管組織の作製2017

    • Author(s)
      福士万由,矢嶋祐也,古澤和也,鵜頭理恵,山田真澄,関 実
    • Organizer
      生物工学若手研究者の集い 夏のセミナー2017
    • Related Report
      2017 Research-status Report
  • [Presentation] 細胞-ECM微粒子集積法を用いた肝細胞の3次元培養と機能評価2017

    • Author(s)
      矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      生物工学若手研究者の集い 夏のセミナー2017
    • Related Report
      2017 Research-status Report
  • [Presentation] ECM微粒子混合3次元培養法における肝細胞機能および微粒子安定性の評価2017

    • Author(s)
      矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      第30回 日本動物細胞工学会2017年度大会
    • Related Report
      2017 Research-status Report
  • [Presentation] マイクロステンシルプレートを用いたECM薄膜作製と細胞共培養への応用2017

    • Author(s)
      岩舘秀樹,木村尚貴,橋本里奈,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      第24回HAB研究機構学術年会
    • Related Report
      2017 Research-status Report
  • [Presentation] コラーゲン微粒子を用いた3次元積層培養における肝細胞の機能評価2017

    • Author(s)
      矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      第24回HAB研究機構学術年会
    • Related Report
      2017 Research-status Report
  • [Presentation] マイクロステンシルプレートを用いた基底膜模倣細胞培養系の開発2017

    • Author(s)
      岩舘秀樹,木村尚貴,橋本里奈,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学とマイクロ・ナノシステム学会第35回研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] リン酸塩‐PDMS流路を用いたコラーゲンチューブの形成とその応用2017

    • Author(s)
      福士万由,矢嶋祐也,古澤和也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学とマイクロ・ナノシステム学会第35回研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Microfluidic Process to “Non-crosslinked” Collagen Microfibers for 3D Cell Cultivation2017

    • Author(s)
      Sakiko Enomoto, Yuya Yajima, Rie Utoh, Masumi Yamada, Kazuya Furusawa, and Minoru Seki
    • Organizer
      Lab-on-a-Chip & Microfluidics, Point-of-Care Diagnostics & Global Health Asia 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Microfluidics-assisted Spinning of Single Micrometer-sized Protein Microfibers Using Alginate as Sacrificial Matrix2017

    • Author(s)
      Hisataka Hiramatsu, Ayaka Hori, Yuya Yajima, Rie Utoh, Masumi Yamada, and Minoru Seki
    • Organizer
      Lab-on-a-Chip & Microfluidics, Point-of-Care Diagnostics & Global Health Asia 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Control of Invasion Direction of Cancer Cells Using Hierarchically Patterned Hydrogel Sheets2017

    • Author(s)
      Manami Sugimoto, Yoichi Kitagawa, Yuya Yajima, Rie Utoh, Masumi Yamada, and Minoru Seki
    • Organizer
      28th 2017 International Symposium on Micro-NanoMechatronics and Human Science (MHS 2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Basement Membrane-Mimetic Microengineered ECM Films for Cell Co-Culture on Front-Back Surfaces2017

    • Author(s)
      Hideki Iwadate, Naoki Kimura, Rina Hashimoto, Yuya Yajima, Rie Utoh, Masumi Yamada, and Minoru Seki
    • Organizer
      The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Collagen Gelation on Phosphate Particle-embedding PDMS (PP-PDMS) Channel: An Efficient Approach to Vascular Tissue Engineering2017

    • Author(s)
      Mayu Fukushi, Yuya Yajima, Rie Utoh, Masumi Yamada, Kazuya Furusawa and Minoru Seki
    • Organizer
      The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Invasion Assay of Cancer Cells Using Hierarchically-patterned Hydrogel Sheets2017

    • Author(s)
      Manami Sugimoto, Yoichi Kitagawa, Yuya Yajima, Rie Utoh, Masumi Yamada, and Minoru Seki
    • Organizer
      RSC Tokyo International Conference 2017 - Analytical Technology Towards Future Society - (JASIS 2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 溶媒乾燥プロセスを用いたタンパク質微粒子の作製とその応用2016

    • Author(s)
      矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      第22回流動化・粒子プロセッシングシンポジウム
    • Place of Presentation
      東京大学 生産技術研究所
    • Year and Date
      2016-12-08
    • Related Report
      2016 Research-status Report
  • [Presentation] Microfabricated Hydrogel Sheets for Guidance and Quantitative Evaluation of Cancer Cell Invasion2016

    • Author(s)
      Masumi Yamada, Manami Sugimoto, Yoichi Kitagawa, Rie Utoh, and Minoru Seki
    • Organizer
      The 22st Symposium of Young Asian Biochemical Engineers’ Community (YABEC 2016)
    • Place of Presentation
      Miyazaki, Japan
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] One-step Production of Non-Crosslinked Collagen Microfibers by pH Modulation in Microfluidic Devices2016

    • Author(s)
      Sakiko Enomoto, Yuya Yajima, Yuki Watabe, Masumi Yamada, Rie Utoh, Kazuya Furusawa, and Minoru Seki
    • Organizer
      The 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)
    • Place of Presentation
      Dublin, Ireland
    • Year and Date
      2016-10-09
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] マイクロ流路とコラーゲン微粒子を用いた潅流可能な毛細血管網の形成2016

    • Author(s)
      宮崎満理,堀綾香,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学とマイクロ・ナノシステム学会第34回研究会
    • Place of Presentation
      幕張メッセ国際会議場
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 湿式紡糸によるコラーゲンファイバーの作製と細胞培養への応用2016

    • Author(s)
      榎本紗希子,矢嶋祐也,渡部有紀,山田真澄,鵜頭理恵,古澤和也,関 実
    • Organizer
      化学工学会第48回秋季大会
    • Place of Presentation
      徳島大学
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] がん細胞の浸潤方向制御を可能とするハイドロゲルシートの作製2016

    • Author(s)
      杉本愛実,北川陽一,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学工学会第48回秋季大会
    • Place of Presentation
      徳島大学
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Fabrication and evaluation of pancreatic islet-like tissues containing ECM microparticles2016

    • Author(s)
      Mao Kameda, Ayaka Hori, Yuya Yajima, Rie Utoh, Masumi Yamada, and Minoru Seki
    • Organizer
      Tissue Engineering and Regenerative Medicine International Society Asia Pacific Meeting (2016 TERMIS AP)
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2016-09-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 3次元細胞培養のための非架橋性コラーゲンファイバーの作製2016

    • Author(s)
      榎本紗希子,矢嶋祐也,渡部有紀,山田真澄,鵜頭理恵,古澤和也,関 実
    • Organizer
      生物工学若手研究者の集い 夏のセミナー2016
    • Place of Presentation
      ホテルコンチネンタル府中
    • Year and Date
      2016-07-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 長期肝障害刺激下における臓器サイズ異所性肝臓の作製2016

    • Author(s)
      鵜頭 理恵、大橋 一夫、和氣 健二郎、岡野 光夫
    • Organizer
      第23回HAB研究機構学術年会
    • Place of Presentation
      つくば産業総合研究所中央第一共用講堂
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Investigation of Proper Transplantation Site of Islet Cell Dheets for Treating Type 1 Diabetes Mellitus2015

    • Author(s)
      Fujita I, Utoh R, Yamamoto M, Shimizu T, Okano T
    • Organizer
      2015 4th Termis World Congress
    • Place of Presentation
      ボストン(アメリカ)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks]

    • URL

      http://chem.tf.chiba-u.jp/gacb01/publications.html

    • Related Report
      2016 Research-status Report
  • [Remarks] 東京女子医科大学 先端生命医科学研究所ホームページ

    • URL

      http://www.twmu.ac.jp/ABMES/ja/2015

    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2020-03-30  

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