Development of Innovative Targeting Hybrid Artificial Pulmonary Surfactant Preparations by Nanomedicine
| Project/Area Number |
26350534
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Nagasaki International University |
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Principal Investigator |
SHIBATA Osamu 長崎国際大学, 薬学部, 教授 (10117129)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAHARA HIROMICHI 長崎国際大学, 薬学部・薬学科, 准教授 (00513235)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 表面・界面物性 / 肺サーファクタント / ナノ医薬品 / インテリジェント・ナノ材 料 / Langmuir単分子膜 / ナノ機能材料 / 呼吸窮迫症候群(RDS) / 偏光変調赤外反射吸収法(PM -IRRAS) / インテリジェント・ナノ材料 / 呼吸急迫症候群 / 偏光変調赤外吸収法(PM-IRRAS) / 偏光変調赤外反射吸収法(PM-IRRAS) |
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| Outline of Final Research Achievements |
The model peptide in artificial hybrid pulmonary surfactant (PS) changes its secondary structure from alpha-helix to beta-sheet upon lateral compression. However, in the presence of anionic lipids such as phosphatidylglycerol and palmitic acid, the conversion of the structure is found to prevent from the spectroscopic aspect. And fluorinated compound additive in PS also very effective for PS preparation. The mechanism and function of PS across the interface have been elucidated from the thermodynamic, morphological, and spectroscopic perspectives. This results will provide a useful preparation of novel artificial hybrid pulmonary surfactant (PS) and also available for extensive respiratory disease (asthma, SARS, COPD et al.).
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Report
(4 results)
Research Products
(95 results)
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[Journal Article] Impairing effect of fibrinogen on the mono-/bi-layer form of bovine lung surfactant2014
Author(s)
Ravi Devraj, Kaushik Nag, Prasant Nahak, Kausik Manna, Mauricia Fritzen-Garcia, David W. Thompson, Kimiko Makino, Hiroyuki Ohshima, Hiromichi Nakahara, Osamu Shibata, Amiya Kumar Panda
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Journal Title
Colloid Polym. Sci.
Volume: 292
Issue: 11
Pages: 2765-2774
DOI
Related Report
Peer Reviewed
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[Journal Article] Effect of Serum, Cholesterol and Low Density Lipoprotein on the Functionality and Structure of Lung Surfactant Films2014
Author(s)
Prasant Nahak, Kaushik Nag, Ashley Hillier, Ravi Devraj, David W. Thompson, Kausik Manna, Kimiko Makino, Hiroyuki Ohshima, Hiromichi Nakahara, Osamu Shibata, Amiya Kumar Panda
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Journal Title
Journal of Oleo Science
Volume: 63
Issue: 12
Pages: 1333-1349
DOI
NAID
ISSN
1345-8957, 1347-3352
Related Report
Peer Reviewed / Open Access
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[Presentation] Examination of aqueous behavior of gemini surfactants (14-s-14,2Br－):effect of methylene spacer lengths2014
Author(s)
Hiromichi Nakahara, Hiroaki Nishizaka, Hideo Akisada, Masashi Nakaya, Kiyoshi Kanie, Atsushi Muramatsu, Osamu Shibata, Examination of aqueous behavior of gemini surfactants (14-s-14,2Br－):effect of methylene spacer lengths
Organizer
15th INTERNATIONAL CONFERENCE ON ORGANIZED MOLECULAR FILMS (ICOMF15-LB15)
Place of Presentation
JEJU, KOREA
Year and Date
2014-07-09 – 2014-07-11
Related Report
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