Development of new intravascular optical coherence tomography for detecting lipid core in coronary atherosclerotic plaques

• Project/Area Number: 26350542
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: Wakayama Medical University
• Principal Investigator: Kubo Takashi 和歌山県立医科大学, 医学部, 准教授 (30316096)
• Co-Investigator(Kenkyū-buntansha): 赤阪 隆史 和歌山県立医科大学, 医学部, 教授 (70322584)
• Research Collaborator: HASEGAWA Takeyoshi ; SHIMOKADA Ai ; NISHIGUCHI Tsuyoshi
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 光干渉断層法 / 冠動脈疾患 / 動脈硬化 / 脂質 / 赤外線

Outline of Final Research Achievements

Using optical coherence tomography (OCT) and spectroscopic algorism, we developed new intravascular imaging method for tissue characterization of coronary atherosclerotic plaques. In the present study, we showed that this new intravascular OCT allows us to detect lipid-rich necrotic core in coronary atherosclerotic plaques which might be associated with the onset of acute myocardial infarction.

Research Products

• [Journal Article] Clinical Utility of Combined Optical Coherence Tomography and Near-Infrared Spectroscopy for Assessing the Mechanism of Very Late Stent Thrombosis. (2018)
  • Author(s): Ino Y, Kubo T, Kameyama T, Shimamura K, Terada K, Matsuo Y, Kitabata H, Shiono Y, Kashiwagi M, Kuroi A, Maniwa N, Ota S, Ozaki Y, Tanaka A, Hozumi T, Akasaka T.
  • Journal Title: JACC Cardiovasc Imaging Volume: 12 Pages: 1-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification of High Risk Plaques for Acute Coronary Syndrome Using Coronary CT Angiography and Computational Fluid Dynamics. (2018)
  • Author(s): Lee MJ, Choi G, Koo BK, Hwang D, Park J, Zhang J, Kim KJ, Tong Y, Kim HJ, Grady L, Taylor C, Doh JH, Shin ES, Cho YS, Choi SU, Chun EJ, Choi JH, Christiansen E, Nieman K, Otake H, Penicka M, Bruyne BD, Kubo T, Akasaka T, Narula J, Douglas P, Kim HS.
  • Journal Title: JACC Cardiovasc Imaging Volume: 9 Pages: 1-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Optical coherence tomography guidance in management of ACS caused by plaque erosion. (2018)
  • Author(s): Jia H, Kubo T, Akasaka T, Yu B.
  • Journal Title: Circ J Volume: 82 Pages: 302-308
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Optical frequency domain imaging versus intravascular ultrasound in percutaneous coronary intervention (OPINION trial): results from the OPINION imaging study. JACC Cardiovasc Imaging. (2018)
  • Author(s): Otake H, Kubo T, Takahashi H, Shinke T, Okamura T, Hibi K, Nakazawa G, Morino Y, Shite J, Fusazaki T, Kozuma K, Ioji T, Kaneda H, Akasaka T.
  • Journal Title: JACC Cardiovasc Imaging Volume: 11 Pages: 111-123
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Automated lipid-rich plaque detection with short wavelength infra-red OCT system. (2017)
  • Author(s): Shimokado A, Kubo T, Nishiguchi T, Taruya A, Teraguchi I, Ohta S, Ozaki Y, Kashiwagi M, Shimamura K, Kuroi A, Kameyama T, Shiono Y, Yamano T, Matsuo Y, Kitabata H, Ino Y, Hozumi T, Tanaka A, Akasaka T.
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 27 Pages: 1-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical Relevance of 18F-Sodium Fluoride Positron-Emission Tomography in Noninvasive Identification of High-Risk Plaque in Patients With Coronary Artery Disease. (2017)
  • Author(s): Lee JM, Bang JI, Koo BK, Hwang D, Park J, Zhang J, Yaliang T, Suh M, Paeng JC, Shiono Y, Kubo T, Akasaka T.
  • Journal Title: Circ Cardiovasc Imaging Volume: 10 Pages: 1-6
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Optical frequency domain imaging versus intravascular ultrasound in percutaneous coronary intervention (OPINION trial): one-year angiographic and clinical results. (2017)
  • Author(s): Kubo T, Shinke T, Okamura T, Hibi K, Nakazawa G, Morino Y, Shite J, Fusazaki T, Otake H, Kozuma K, Ioji T, Kaneda H, Serikawa T, Kataoka T, Okada H, Akasaka T.
  • Journal Title: Eur Heart J Volume: 38 Pages: 3139-3147
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Assessment of Vascular Response after Drug-eluting Stents Implantation in Patients with Diabetes Mellitus: An Optical Coherence Tomography Sub-study of the J-DESsERT (2016)
  • Author(s): Kubo T, Akasaka T, Tanimoto T, Takano M, Seino Y, Nasu K, Itoh T, Mizuno K, Okura H, Shinke T, Kotani J, Ito S, Yokoi H, Muramatsu T, Nakamura M, Nanto S
  • Journal Title: Heart Vessels. Volume: 31 Pages: 465-473
  • Peer Reviewed
• [Journal Article] Optimal threshold of post-intervention minimum stent area to predict in-stent restenosis in small coronary arteries: An optical coherence tomography analysis (2016)
  • Author(s): Matsuo Y, Kubo T, Aoki H, Satogami K, Ino Y, Kitabata H, Taruya A, Nishiguchi T, Teraguchi I, Shimamura K, Shiono Y, Orii M, Yamano T, Tanimoto T, Yamaguchi T, Hirata K, Tanaka A, Akasaka T
  • Journal Title: Catheter Cardiovasc Interv Volume: 87
  • Peer Reviewed
• [Journal Article] Assessment of vascular response after stent implantation by intracoronary optical coherence tomography (2016)
  • Author(s): Ino Y, Kubo T, Matsuo Y, Kitabata H, Kameyama T, Tanaka A, Akasaka T
  • Journal Title: Journal of Cardiology and Therapeutics Volume: 4 Pages: 21-33
  • Peer Reviewed
• [Journal Article] Angiographic, optical coherence tomography and histology findings from combination of a drug-coated balloon with an everolimus-eluting stent in a porcine model (2016)
  • Author(s): Ong P, Kubo T, Watson T, Seah A, Wong P, Akasaka T
  • Journal Title: International Journal of Cardiology Volume: 223 Pages: 665-668
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Optical frequency domain imaging of covered stent-graft for pulmonary artery pseudoaneurysm after balloon pulmonary angioplasty (2016)
  • Author(s): Horimoto K, Abe K, Ohtani K, Takahara Y, Hosokawa K, Oi K, Mukai Y, Kubo T, Matoba T, Tsutsui H
  • Journal Title: JACC cardiovasc interv Volume: 9 Pages: 2255-2256
  • Peer Reviewed / Open Access
• [Journal Article] Optical coherence tomography predictors for edge restenosis after everolimus-eluting stent implantation (2016)
  • Author(s): Ino Y, Kubo T, Matsuo Y, Yamaguchi T, Shiono Y, Shimamura K, Katayama Y, Nakamura T, Aoki H, Taruya A, Nishiguchi T, Satogami K, Yamano T, Kameyama T, Orii M, Oota S, Kuroi A, Kitabata H, Tanaka A, Hozumi T, Akasaka T
  • Journal Title: Circ Cardiovasc Interv Volume: 9 Pages: 4231-4231
  • Peer Reviewed / Open Access
• [Journal Article] Advances in coronary artery imaging (2016)
  • Author(s): Kameyama T, Ino Y, Kubo T, Akasaka T
  • Journal Title: J Jpn Coron Assoc Volume: 22 Pages: 39-44
  • NAID: 130005138918
  • Peer Reviewed
• [Journal Article] III. 冠循環の病理・病態 2．冠動脈プラークの発生・進展機序（4）冠動脈プラークと血管リモデリング (2016)
  • Author(s): 久保隆史, 赤阪隆史
  • Journal Title: 日本臨床 Volume: 74 Pages: 100-108
• [Journal Article] 特集「IVUS vs. OCT : 血管内イメージングの今」識る 7. [Expertise] 冠動脈内融合イメージング（NIRS-IVUS・OCT-IVUS・NIRS-OCT）の可能性を識る. (2016)
  • Author(s): 亀山剛義, 猪野靖, 久保隆史, 赤阪隆史
  • Journal Title: Heart view Volume: 20 Pages: 51-58
• [Journal Article] 特集「IVUS vs. OCT : 血管内イメージングの今」治す 9. VH-IVUS・NIRS-IVUSガイドで治す (2016)
  • Author(s): 久保隆史, 赤阪隆史
  • Journal Title: Heart view Volume: 20 Pages: 65-69
• [Journal Article] 血管内イメージングの有用性と進歩－gray scale IVUS, OCT, NIRS-IVUS について (2016)
  • Author(s): 亀山剛義, 猪野 靖, 久保隆史, 赤阪隆史
  • Journal Title: 呼吸と循環 Volume: 64 Pages: 382-390
  • NAID: 40020814250
• [Journal Article] Superficial calcium fracture after percutaneous coronary intervention as assessed by optical coherence tomography. (2015)
  • Author(s): Kubo T, Shimamura K, Ino Y, Yamaguchi T, Matsuo Y, Shiono Y, Taruya A, Nishiguchi T, Shimokado A, Teraguchi I, Orii M, Yamano T, Tanimoto T, Kitabata H, Hirata K, Tanaka A, Akasaka T.
  • Journal Title: JACC Cardiovasc Imaging. Volume: 8 Issue: 10 Pages: 1228-1229
  • DOI: 10.1016/j.jcmg.2014.11.012
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of neointimal coverage between everolimuseluting stents and sirolimus-eluting stents: class FormattedString { value: An optical coherence tomography substudy of the RESET (Randomized Evaluation of Sirolimus-eluting versus Everolimus-eluting stent Trial) } (2015)
  • Author(s): Kubo T, Akasaka T, Kozuma K, Kimura K, Kawamura M, Sumiyoshi T, Ino Y, Morino Y, Tanabe K, Kadota K, Kimura T
  • Journal Title: EuroIntervention Volume: 11 Issue: 5 Pages: 564
  • DOI: 10.4244/eijv11i5a109
  • URL: https://localhost/en/publications/e4235a6e-2a20-4828-81dd-7c1fb9a37762
  • Peer Reviewed / Open Access
• [Journal Article] Feasibility of Optical Coronary Tomography in Quantitative Measurement of Coronary Arteries With Lipid-Rich Plaque (2015)
  • Author(s): Kubo T, Yamano T, Liu Y, Ino Y, Shiono Y, Orii M, Taruya A, Nishiguchi T, Shimokado A, Teraguchi I, Tanimoto T, Kitabata H, Yamaguchi T, Hirata K, Tanaka A, Akasaka T.
  • Journal Title: Circulation Journal Volume: 79 Issue: 3 Pages: 600-606
  • DOI: 10.1253/circj.CJ-14-1085
  • NAID: 130004927118
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of Coronary Atherosclerosis by Optical Coherence Tomography. (2014)
  • Author(s): Kubo T, Tanaka A, Ino Y, Kitabata H, Shiono Y, Akasaka T.
  • Journal Title: J Atheroscler Thromb. Volume: 21 Pages: 895-903
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of coronary arterial lesions due to Kawasaki disease using optical coherence tomography. (2014)
  • Author(s): Kakimoto N, Suzuki H, Kubo T, Suenaga T, Takeuchi T, Shibuta S, Ino Y, Akasaka T, Yoshikawa N.
  • Journal Title: Can J Cardiol. Volume: 30
  • Peer Reviewed
• [Journal Article] Vascular Responses to Drug-Eluting Stents with Biodegradable Polymer versus Durable Polymer: An Optical Coherence Tomography Sub-study of the NEXT. (2014)
  • Author(s): Kubo T, Akasaka T, Kozuma K, Kimura K, Fusazaki T, Okura H, Shinke T, Ino Y, Hasegawa T, Takashima H, Takamisawa I, Yamaguchi H, Igarashi K, Kadota K, Tanabe K, Nakagawa Y, Muramatsu T, Morino Y, MD, Kimura T
  • Journal Title: Circ J. Volume: 78 Pages: 2408-2414
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Atorvastatin Therapy on the Fibrous Cap Thickness in Coronary Atherosclerotic Plaque as Assessed by Optical Coherence Tomography: The EASY-FIT Study. (2014)
  • Author(s): Komukai K, Kubo T, Kitabata H, Matsuo Y, Ozaki Y, Takarada S, Okumoto Y, Shiono Y, Orii M, Shimamura K, Ueno S, Yamano T, Tanimoto T, Ino Y, Yamaguchi T, Kumiko H, Tanaka A, Imanishi T, Akagi H, Akasaka T.
  • Journal Title: J Am Coll Cardiol. Volume: 64 Pages: 2207-2217
  • Peer Reviewed / Open Access
• [Journal Article] Difference of ruptured plaque morphology between asymptomatic coronary artery disease and non-ST elevation acute coronary syndrome patients: An optical coherence tomography study. (2014)
  • Author(s): Shimamura K, Ino Y, Kubo T, Nishiguchi T, Tanimoto T, Ozaki Y, Satogami K, Orii M, Shiono Y, Komukai K, Yamano T, Matsuo Y, Kitabata H, Yamaguchi T, Hirata K, Tanaka A, Imanishi T, Akasaka T.
  • Journal Title: Atherosclerosis. Volume: 235 Pages: 532-537
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of diagnostic accuracy between multidetector computed tomography and virtual histology intravascular ultrasound for detecting optical coherence tomography-derived fibroatheroma. (2014)
  • Author(s): Kashiwagi M, Tanaka A, Kitabata H, Ozaki Y, Komukai K, Tanimoto T, Ino Y, Kubo T, Hirata K, Imanishi T, Akasaka T.
  • Journal Title: Cardiovasc Interv Ther. Volume: 29 Pages: 102-108
  • Peer Reviewed
• [Journal Article] Impact of glucose fluctuation and monocyte subsets on coronary plaque rupture. (2014)
  • Author(s): Teraguchi I, Imanishi T, Ozaki Y, Tanimoto T, Orii M, Shiono Y, Shimamura K, Ishibashi K, Yamano T, Ino Y, Yamaguchi T, Hirata K, Kubo T, Akasaka T.
  • Journal Title: Nutr Metab Cardiovasc Dis. Volume: 24 Pages: 309-314
  • Peer Reviewed
• [Journal Article] Association between P-selectin glycoprotein ligand-1 and pathogenesis in acute coronary syndrome assessed by optical coherence tomography. (2014)
  • Author(s): Ozaki Y, Imanishi T, Teraguchi I, Nishiguchi T, Orii M, Shiono Y, Shimamura K, Ishibashi K, Tanimoto T, Yamano T, Ino Y, Yamaguchi T, Kubo T, Akasaka T.
  • Journal Title: Atherosclerosis. Volume: 233 Pages: 697-703
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Longitudinal Geometric Measurement in Human Coronary Arteries between Frequency-domain Optical Coherence Tomography and Intravascular Ultrasound. (2014)
  • Author(s): Liu Y, Shimamura K, Kubo T, Tanaka A, Kitabata H, Ino Y, Tanimoto T, Shiono Y, Orii M, Yamano T, Yamaguchi T, Hirata K, Imanishi T, Akasaka T.
  • Journal Title: Int J Cardiovasc Imaging. Volume: 30 Pages: 271-277
  • Peer Reviewed / Open Access
• [Presentation] Imaging or Physiology: Which is more useful for coronary artery disease. OCT in coronary artery disease. (2018)
  • Author(s): Kubo T.
  • Organizer: The 82st Annual Scientific Meeting of the Japanese Circulation Society (JCS2018)
  • Int'l Joint Research / Invited
• [Presentation] OCT is superior to IVUS. (2018)
  • Author(s): Kubo T.
  • Organizer: The 13th Asian Interventional Cardiovascular Therpeutics (AICT 2017)
  • Int'l Joint Research / Invited
• [Presentation] Update Role of OFDI and FFR in Coronary Intervention. (2018)
  • Author(s): Kubo T.
  • Organizer: The 8th Annual Scientific Meeting of Cardiovascular Intervention Association of Thailand (CIAT 2017)
  • Int'l Joint Research / Invited
• [Presentation] May the FFR be with you (2017)
  • Author(s): 久保隆史
  • Organizer: 第81回 日本循環器学会学術集会
  • Place of Presentation: 金沢市
  • Year and Date: 2017-03-17
• [Presentation] Current status and future perspectives of intracoronary OCT (2017)
  • Author(s): Kubo T
  • Organizer: 第81回 日本循環器学会学術集会
  • Place of Presentation: 金沢市
  • Year and Date: 2017-03-17
• [Presentation] OCT-guided cutting-balloon lesion preparation and stent implantation in severe calcified lesion (2017)
  • Author(s): Kubo T
  • Organizer: Asia PCR
  • Place of Presentation: Singapore
  • Year and Date: 2017-01-19
  • Int'l Joint Research / Invited
• [Presentation] Reduction of In-stent Thrombus Immediately After PCI by Pretreatment With Prasugrel Assessed by OCT. (2017)
  • Author(s): Kubo T.
  • Organizer: Trascathter Therapeutics 2017
  • Int'l Joint Research / Invited
• [Presentation] Non flow-limiting vulnerable plaques detected by optical coherence tomography. (2017)
  • Author(s): Kubo T.
  • Organizer: European society of cardiology
  • Int'l Joint Research / Invited
• [Presentation] イメージングから見たDESポリマーの意義 (2016)
  • Author(s): 久保隆史
  • Organizer: 第2回 Pan-Pacific Primary Angioplasty Conferenec 2016
  • Place of Presentation: 京都市
  • Year and Date: 2016-11-18
  • Invited
• [Presentation] Role of Imaging for STEMI (2016)
  • Author(s): 久保隆史
  • Organizer: 第2回 Pan-Pacific Primary Angioplasty Conferenec 2016
  • Place of Presentation: 京都市
  • Year and Date: 2016-11-18
  • Invited
• [Presentation] Different Vascular Healing Process between Bioabsorbable Polymer-coated Everolimus-Eluting Stents versus Bioresorbable Vascular Scaffolds via Optical Coherence Tomography and Coronary Angiosopy: Early Results from ENdothelial Healing Assessment With Novel Coronary tEchnology (ENHANCE study) (2016)
  • Author(s): Ahmad WA, Nakayoshi T, Zuhdi AS, Ismail MD, Ino Y, Kubo T, Akasaka T, Fukumoto Y, Ueno T
  • Organizer: TCT
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2016-10-30
  • Int'l Joint Research
• [Presentation] OCT Follow-Up Substudy from a Randomized Trial of OFDI-Guided PCI vs. IVUS-Guided PCI (2016)
  • Author(s): Oatke M, Kubo T, Takahashi H, Shinke T, Okamura T, Hibi K, Nakazawa G, Morino Y, Shite J, Fusazaki T, Kozuma K, Akasaka T
  • Organizer: TCT
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2016-10-30
  • Int'l Joint Research
• [Presentation] OCTによるHigh risk plaqueの同定 (2016)
  • Author(s): 久保隆史
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2016-09-23
  • Invited
• [Presentation] 不安定プラークイメージングの基礎基本 (2016)
  • Author(s): 久保隆史
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2016-09-23
  • Invited
• [Presentation] 画像診断による冠動脈硬化の進展と退縮：IVUS・OCTで見る冠動脈硬化の進展と退縮 (2016)
  • Author(s): 久保隆史
  • Organizer: 第48回動脈硬化学会総会・学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2016-07-14
  • Invited
• [Presentation] AMIの診断と治療に血管内イメージングを活用する (2016)
  • Author(s): 久保隆史
  • Organizer: 第25回日本心血管インターベンション治療学会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2016-07-07
  • Invited
• [Presentation] Utilizing coronary physiology in daily practice (2016)
  • Author(s): 久保隆史
  • Organizer: 第25回日本心血管インターベンション治療学会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2016-07-07
  • Invited
• [Presentation] Non-invasive identification of high-risk vulnerable coronary atherosclerotic plaque using 18F-sodium fluoride positron emission tomography in patients with stable coronary artery disease (2016)
  • Author(s): Lee JM, Koo BK, Kubo T, Akasaka T
  • Organizer: EuroPCR
  • Place of Presentation: Paris, France
  • Year and Date: 2016-05-17
  • Int'l Joint Research
• [Presentation] Haemodynamic force analysis improves noninvasive prediction of risk of ACS: the results of first-in-man EMERALD study (exploring the mechanism of the plaque rupture in acute coronary syndrome using coronary CT angiography and computational fluid dynamics) (2016)
  • Author(s): Koo BK, Kubo T, Akasaka T
  • Organizer: EuroPCR
  • Place of Presentation: Paris, France
  • Year and Date: 2016-05-17
  • Int'l Joint Research
• [Presentation] Intracoronary Imaging Update New Imaging Technology: State-of-the-Art: Plaque Assessment by Combined OCT-Spectroscopy. (2015)
  • Author(s): Kubo T
  • Organizer: 8th Imaging and physiology summit 2015.
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2015-12-04
  • Int'l Joint Research / Invited
• [Presentation] PCI to ACS presenting normal coronary angiography. (2015)
  • Author(s): Kubo T
  • Organizer: 10th Korean Society of Interventional Cardiology (KSIC) Youngnam Branch Symposium.
  • Place of Presentation: Gyeongju, Korea
  • Year and Date: 2015-11-21
  • Int'l Joint Research / Invited
• [Presentation] Identification and Treatment of High-Risk Lesions in ACS with OCT Guidance. Learn the Technique: Nuts and Bolts of OCT Imaging. (2015)
  • Author(s): Kubo T
  • Organizer: TCT 2015
  • Place of Presentation: San Fransisico, CA, USA
  • Year and Date: 2015-10-12
  • Int'l Joint Research / Invited
• [Presentation] Clinical impact of coronary calcium fracture by percutaneous coronary intervention on the outcomes after everolimus-eluting stent implantation: An optical coherence tomography study. (2015)
  • Author(s): Kubo T, Shimamura K, Katayama Y, Ino Y, Yamaguchi T, Matsuo Y, Shiono Y, Taruya A, Nishiguchi T, Orii M, Yamano T, Hirata K, Tanaka A, Akasaka T.
  • Organizer: EuroPCR 2015
  • Place of Presentation: Paris, France
  • Year and Date: 2015-05-19
  • Int'l Joint Research
• [Presentation] ACS with apparently normal coronary angiography. CVIT@EuroPCR – Integrated physiology and imaging use for strategy change and decision making in complex PCI. (2015)
  • Author(s): Kubo T, Akasaka T.
  • Organizer: EuroPCR 2015
  • Place of Presentation: Paris, France
  • Year and Date: 2015-05-19
  • Int'l Joint Research / Invited
• [Presentation] OCT. Basic concept and interpretation. (2014)
  • Author(s): Kubo T.
  • Organizer: 7th IMAGING & PHYSIOLOGY SUMMIT 2014.
  • Place of Presentation: Seoul, Korea.
  • Year and Date: 2014-12-05 – 2014-12-06
  • Invited
• [Presentation] Plarque charactetristiics by OCT in ACS. (2014)
  • Author(s): Kubo T.
  • Organizer: The 33rd KSIC (Korean Sociey of Interventional Cardiology) 2014.
  • Place of Presentation: Muju. Korea.
  • Year and Date: 2014-10-17 – 2014-10-18
  • Invited
• [Presentation] OCT-guided PCI in Severe Calcified Lesion. (2014)
  • Author(s): Kubo T.
  • Organizer: Complex Cardiovascular Catheter Therapeutics (C3) 2014.
  • Place of Presentation: Florida. USA.
  • Year and Date: 2014-06-23 – 2014-06-27
  • Invited
• [Presentation] OCT-guided PCI in Severe Calcified Lesion. (2014)
  • Author(s): Kubo T.
  • Organizer: Imaging and Physiology Oriented Percutaneous Coronary Intervention Korea (iPOP-Korea) 2014.
  • Place of Presentation: Jeju, Korea.
  • Year and Date: 2014-06-20 – 2014-06-21
  • Invited
• [Presentation] Clinical Application of OCT for Complex PCI and Future Perspectives. (2014)
  • Author(s): Kubo T.
  • Organizer: Imaging and Physiology Oriented Percutaneous Coronary Intervention Korea (iPOP-Korea) 2014.
  • Place of Presentation: Jeju, Korea.
  • Year and Date: 2014-06-20 – 2014-06-21
  • Invited
• [Presentation] Coronary Plaque Stabilization and Destabilization as Assessed by OCT. (2014)
  • Author(s): Kubo T.
  • Organizer: Imaging and Physiology Oriented Percutaneous Coronary Intervention Korea (iPOP-Korea) 2014.
  • Place of Presentation: Jeju, Korea.
  • Year and Date: 2014-06-20 – 2014-06-21
  • Invited
• [Presentation] OCT guided PCI. (2014)
  • Author(s): Kubo T.
  • Organizer: Korean Cardiovascular Imaging (K-Imaging) 2014.
  • Place of Presentation: Gwangju, Korea.
  • Year and Date: 2014-06-13 – 2014-06-14
  • Invited
• [Presentation] Vascular responses to DES with biodegradable polymer versus durable polymer: an OCT sub-study of the NEXT. (2014)
  • Author(s): Kubo T.
  • Organizer: EuroPCR 2014.
  • Place of Presentation: Paris, France.
  • Year and Date: 2014-05-20 – 2014-05-23
• [Presentation] Prediction and prevention of acute coronary syndrome by using OCT. Symposium: Intracoronary OCT - Current status and future perspectives - (2014)
  • Author(s): Kubo T.
  • Organizer: World Congress of Cardiology 2014.
  • Place of Presentation: Melbourne, Australia.
  • Year and Date: 2014-05-04 – 2014-05-07
  • Invited
• [Presentation] IVUS guided vs. OCT guided in current PCI practice. Partnership Session with International Society HKSTENT Session @TCTAP 2014. (2014)
  • Author(s): Kubo T.
  • Organizer: 19th Cardiovascular summit Trans-Catheter Terapeutics Asia Pasific 2014.
  • Place of Presentation: Seul, Korea.
  • Year and Date: 2014-04-22 – 2014-04-25
  • Invited
• [Book] 心筋梗塞発症機序：画像診断による検討. 心筋梗塞から命を守る：発症機序の解明と緊急心血管病克服への地域社会構築の最前線. (2018)
  • Author(s): 久保隆史.
  • Total Pages: 98
  • Publisher: ライフサイエンス出版
• [Book] 45症例で極める冠動脈疾患の画像診断-最適なモダリティを選び・活かす. (2017)
  • Author(s): 久保隆史
  • Total Pages: 182
  • Publisher: 文光堂
• [Book] 日本臨床 第75巻増刊号4 特集：動脈・静脈の疾患（上）最新の診断・治療動向 (2017)
  • Author(s): 尾﨑雄一, 久保隆史, 赤阪隆史.
  • Total Pages: 288
  • Publisher: 日本臨床社
• [Book] 診断と治療のABC120-狭心症 (2017)
  • Author(s): 亀山剛義, 久保隆史, 赤阪隆史.
  • Total Pages: 118
  • Publisher: 最新医学社
• [Book] 虚血性心疾患：画像診断の現状と展開 (2017)
  • Author(s): 亀山剛義, 久保隆史, 赤阪隆史.
  • Total Pages: 598
  • Publisher: 科学評論社
• [Book] 9.45症例で極める冠動脈疾患の画像診断-最適なモダリティを選び・活かす (2017)
  • Author(s): 久保隆史, 赤阪隆史
  • Total Pages: 182
  • Publisher: 文光堂
• [Book] 各論Ⅰ：虚血評価の技術を極める 1. 冠内圧・冠血流評価 c. CFR 「虚血評価ハンドブック - PCI・カテーテル室スタッフが知っておくべき最新の知識」 (2016)
  • Author(s): 塩野泰紹, 久保隆史, 赤阪隆史
  • Total Pages: 93
  • Publisher: 南江堂
• [Book] 3章 研修で学ぶべき知識と技術 Ａ. 検査13．血管内診断機器(IVUS, OCT, FFR). 「循環器研修ノート 改訂第2版」 (2016)
  • Author(s): 青木 浩, 久保隆史, 赤阪隆史
  • Total Pages: 156
  • Publisher: 診断と治療社
• [Book] III．虚血性心疾患 ２．心筋虚血診断の新たな展開. 「Annual Review 循環器 2016」 (2016)
  • Author(s): 塩野泰紹, 久保隆史, 赤阪隆史
  • Total Pages: 111
  • Publisher: 中学医学社
• [Book] Ⅲ 不安定プラークに迫る. 「Integrated Cardiac Imaging：画像で病態に迫る、治療効果を判定する」 (2016)
  • Author(s): 樽谷 玲, 久保隆史, 赤阪隆史
  • Total Pages: 115
  • Publisher: メジカルビュー社
• [Book] 第3章 診断. 冠動脈イメージングの進歩：IVUS・OCT・NIRSを使用したPCIの実例. 最新医学 別冊 診断と治療のABC 120 狭心症. (2016)
  • Author(s): 亀山剛義, 久保隆史, 赤阪隆史
  • Total Pages: 118
  • Publisher: 最新医学社
• [Book] 第３章 BRSをイメージングでどのように評価するか 8. OCT/OFDI. BRS（生体吸収性スキャフォールド） User's Guide - The 1st Edition - 2016 (2016)
  • Author(s): 久保隆史
  • Total Pages: 52
  • Publisher: 株式会社メディシンラトル
• [Book] Textbook of Interventional Cardiology. (2015)
  • Author(s): Topol E, Teirstein PS, Guagliumi G, Akasaka T, Sirbu V, Kubo T
  • Total Pages: 1104
  • Publisher: Elsevier Health Sciences, Philadelphia, USA
• [Book] Coronary Stenosis: Imaging, Structure and Physiology - 2nd Edition - Updated digital version. (2015)
  • Author(s): Javier Escaned, Patrick W. Serruys, Kubo T, Akasaka T.
  • Total Pages: 536
  • Publisher: PCR publishing
• [Book] Cardiovascular OCT Imaging. Springer International Publishing. (2014)
  • Author(s): Kume T, Kubo T, Akasaka T, Jang-IK
  • Total Pages: 222
  • Publisher: Springer International Publishing.