Development of Novel Antitumor Treatment by Sonodynamically Activated Hydroxyl Functionalized Carbon Nanotubes
| Project/Area Number |
26350550
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Yokohama College of Pharmacy |
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Principal Investigator |
FUKAI TOSHIO 横浜薬科大学, 薬学部, 教授 (10057755)
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| Co-Investigator(Kenkyū-buntansha) |
弓田 長彦 横浜薬科大学, 薬学部, 教授 (40191481)
岩瀬 由未子 横浜薬科大学, 薬学部, 講師 (00521882)
梅村 晋一郎 東北大学, 医工学研究科, 教授 (20402787)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アポトーシス / 一重項酸素 / 活性酸素種 / 超音波 / 音響化学療法 / 機能性カーボンナノチューブ / 水酸化カーボンナノチューブ / 音響化学的 / カーボンナノチューブ / 活性酸素 |
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| Outline of Final Research Achievements |
In this study, the sonodynamically induced antitumor effect of hydroxyl functionalized carbon nanotubes (OH-CNT) was investigated. Sonodynamically induced antitumor effects of OH-CNT by focused ultrasound were investigated using isolated sarcoma 180 cells and mice bearing ectopically-implanted colon 26 carcinoma. Cell damage induced by ultrasonic exposure was enhanced by five-fold in the presence of 80 uM OH-CNT. The combined treatment of ultrasound and OH-CNT suppressed the growth of the implanted colon 26 carcinoma. Histidine, a reactive oxygen scavenger, significantly reduced cell damage caused by ultrasonic exposure in the presence of CNT OH-CNT. These results suggest that singlet oxygen is likely to be involved in the ultrasonically induced cell damage enhanced by CNT.
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Report
(4 results)
Research Products
(13 results)
