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Personalized Biomarker Analysis Using Circulating Tumor Cells

Research Project

Project/Area Number 26350557
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionToyama Industrial Technology Center,

Principal Investigator

TAKATA Koji  富山県工業技術センター, 機械電子研究所, 主任研究員 (40530621)

Co-Investigator(Kenkyū-buntansha) 塚田 一博  富山大学, 大学院医学薬学研究部(医学), 教授 (90171967)
嶋田 裕  京都大学, 薬学研究科, 客員教授 (30216072)
長田 拓哉  富山大学, 附属病院, 講師 (40303242)
横堀 武彦  群馬大学, 未来先端研究機構, 講師 (60420098)
Co-Investigator(Renkei-kenkyūsha) OHNAGA Takashi  富山県工業技術センター, 中央研究所, 副主幹研究員 (10416133)
OBATA Tsutomu  富山県工業技術センター, 中央研究所, 副主幹研究員 (30416143)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords循環腫瘍細胞 / 癌 / マイクロ流路チップ / マイクロ流体チップ
Outline of Final Research Achievements

Circulating tumor cells (CTC) are tumor-derived cells circulating in bloodstream and could be seeds for metastases. Easy-to-use isolation and analysis methods of CTC could be applicable to cancer diagnosis and personalized medicine. In this study, we developed microfluidic chips which could be used for size-based cell separation. We showed that the chip could successfully separate cell line spiked to blood, and showed that CTC isolated from clinical sample by the chip could be used for RT-PCR-based biomarker analysis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2017 2016 2015

All Presentation (2 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] 新型CTCチップの臨床応用を目指して2017

    • Author(s)
      横堀武彦、大竹紗弥香、解良恭一、大永崇、高田耕児、鈴木信、浅尾高行、桑野博行
    • Organizer
      日本外科学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] CTC sorting chips: polymer microfluidic chips for marker-dependent and -independent isolation of circulating tumor cells2015

    • Author(s)
      高田耕児、大永崇、長田拓哉、嶋田裕、塚田一博
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 細胞を分離する方法及び装置2016

    • Inventor(s)
      高田耕児、大永崇、小幡勤
    • Industrial Property Rights Holder
      富山県
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-077717
    • Filing Date
      2016-04-08
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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